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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nyjGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nyjGNPGTPase HRas/1.000
4nyiGNPGTPase HRas/0.644
5dhaGNPGTP-binding nuclear protein Ran/0.608
3rs5GNPGTPase HRas/0.603
3v4fGNPGTPase HRas/0.594
3oiuGNPGTPase HRas/0.585
3i3sGNPGTPase HRas/0.580
4dsnGCPGTPase KRas/0.575
1zbdGTPRas-related protein Rab-3A/0.573
1xtsGTPGTP-binding protein Rheb/0.571
3lbnGNPGTPase HRas/0.571
3oesGNPGTPase RhebL1/0.571
1g17GNPRas-related protein SEC4/0.567
1zc4GNPRas-related protein Ral-A/0.567
1e96GTPRas-related C3 botulinum toxin substrate 1/0.563
3ddcGNPGTPase HRas/0.563
1zc3GNPRas-related protein Ral-A/0.561
2c5lGTPGTPase HRas/0.561
2rgeGNPGTPase HRas/0.561
3oivGNPGTPase HRas/0.560
3a58GNPGTP-binding protein RHO1/0.559
3e5hGNPRas-related protein Rab-28/0.558
3kkoGNPRas-related protein M-Ras/0.555
5jljGNPGTP-binding nuclear protein Ran/0.555
1ibrGNPGTP-binding nuclear protein Ran/0.553
3ea5GDPGTP-binding nuclear protein Ran/0.553
3l8yGNPGTPase HRas/0.552
4k81GTPGTPase HRas/0.552
2rgbGNPGTPase HRas/0.551
3nbzGTPGTP-binding nuclear protein Ran/0.551
4lhwGNPRas-related protein Rab-8A/0.551
3kucGDPRas-related protein Rap-1A/0.550
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.549
2zetGTPRas-related protein Rab-27B/0.549
4dltGNPGTPase HRas/0.549
1yzqGNPRas-related protein Rab-6A/0.548
4kvgGTPRas-related protein Rap-1A/0.547
1kmqGNPTransforming protein RhoA/0.546
1t91GTPRas-related protein Rab-7a/0.544
1xtrGNPGTP-binding protein Rheb/0.542
3w3zGTPGTP-binding nuclear protein Ran/0.540
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.539
3kudGDPGTPase HRas/0.538
4g0nGNPGTPase HRas/0.538
4qxaGTPRas-related protein Rab-9A/0.536
3a6pGTPGTP-binding nuclear protein Ran/0.535
2rgcGNPGTPase HRas/0.534
4dlxGNPGTPase HRas/0.533
4mitGTPRho-related protein racC/0.533
3lawGNPRas-related protein Rab-7a/0.530
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.530
5b2zGNPGTPase HRas/0.528
1cxzGSPTransforming protein RhoA/0.527
3rs7GNPGTPase HRas/0.527
3lbhGNPGTPase HRas/0.526
3pitGNPRas-related protein M-Ras/0.526
2gilGTPRas-related protein Rab-6A/0.525
3bbpGTPRas-related protein Rab-6A/0.525
4dxaGSPRas-related protein Rap-1b/0.524
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.522
4dlwGNPGTPase HRas/0.522
1m7bGTPRho-related GTP-binding protein RhoE/0.521
3oiwGNPGTPase HRas/0.520
3tsoGNPRas-related protein Rab-25/0.520
1a2bGSPTransforming protein RhoA/0.519
4js0GNPCell division control protein 42 homolog/0.518
1uadGNPRas-related protein Ral-A/0.517
3tnfGNPRas-related protein Rab-8A/0.517
4hdoGNPRas-related protein Rap-1b/0.517
4o25GTPGTP-binding protein Rheb/0.517
3eg5GNPCell division control protein 42 homolog/0.515
4xvrGNPGTPase HRas/0.515
2gcpGSPRho-related GTP-binding protein RhoC/0.514
3kz1GSPTransforming protein RhoA/0.513
1yhnGTPRas-related protein Rab-7a/0.512
2bkuGTPGTP-binding nuclear protein Ran/0.512
2fe4GDPRas-related protein Rab-6B/0.511
2ffqGSPRas-related protein Rab-6B/0.511
3rs4GNPGTPase HRas/0.511
4dlzGNPGTPase HRas/0.510
4dsoGSPGTPase KRas/0.508
4rkfGNPRas-related protein Rab-3/0.508
1lfdGNPGTPase HRas/0.507
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.507
4dlvGNPGTPase HRas/0.507
4xoiGTPTransforming protein RhoA/0.505
1z2cGNPRho-related GTP-binding protein RhoC/0.504
3lbiGNPGTPase HRas/0.504
1k5dGNPGTP-binding nuclear protein Ran/0.502
2msdGNPMHC class I alpha chain/0.501
3rslGNPGTPase HRas/0.501
5difGNPGTP-binding nuclear protein Ran/0.501
3x1zGNPRas-related protein Rap-1b/0.500
1vg8GNPRas-related protein Rab-7a/0.499
1ow3GDPTransforming protein RhoA/0.498
3bc1GNPRas-related protein Rab-27A/0.498
3k8yGNPGTPase HRas/0.498
4ol0GTPGTP-binding nuclear protein Ran/0.497
1oixGDPRas-related protein Rab-11A/0.496
4hdqGNPRas-related protein Rap-1b/0.496
4xvqGNPGTPase HRas/0.496
2cl6CAGGTPase HRas/0.495
2rggGNPGTPase HRas/0.495
4dlsGNPGTPase HRas/0.495
5hpyGDPTransforming protein RhoA/0.495
3tgpGNPGTPase HRas/0.493
3th5GNPRas-related C3 botulinum toxin substrate 1/0.492
4dsuGDPGTPase KRas/0.492
1s1cGNPTransforming protein RhoA/0.490
2clsGTPRho-related GTP-binding protein Rho6/0.490
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.490
3rabGNPRas-related protein Rab-3A/0.490
4q02GDPGTPase KRas/0.490
4uj3GNPRas-related protein Rab-11A/0.488
4lucGDPGTPase KRas/0.487
3qbtGNPRas-related protein Rab-8A/0.486
5c46GSPRas-related protein Rab-11A/0.485
3kkqGDPRas-related protein M-Ras/0.479
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.478
4l8gGDPGTPase KRas/0.478
4lv6GDPGTPase KRas/0.477
4lpkGDPGTPase KRas/0.475
3x1wGDPRas-related protein Rap-1b/0.473
4tq9GDPGTPase KRas/0.472
4cymGCPRas-related protein Rab-32/0.471
4l9sGDPGTPase HRas/0.471
1zd9GDPADP-ribosylation factor-like protein 8A/0.469
3tklGTPRas-related protein Rab-1A/0.469
4l9wGNPGTPase HRas/0.467
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.464
4epwGDPGTPase KRas/0.463
3mjhGTPRas-related protein Rab-5A/0.458
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.457
4o2lGTPGTP-binding protein Rheb/0.457
4obeGDPGTPase KRas/0.457
1gwnGTPRho-related GTP-binding protein RhoE/0.456
4ldjGDPGTPase KRas/0.456
4wa7GDPGTPase KRas/0.455
4uj5GNPRas-related protein Rab-11A/0.454
4epxGDPGTPase KRas/0.453
4q03GDPGTPase KRas/0.452
1z0aGDPRas-related protein Rab-2A/0.448
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.447
4o2rGDPGTP-binding protein Rheb/0.446
2fg5GNPRas-related protein Rab-31/0.444
1d5cGDPGTPase (Rab6)/0.443
2ce2GDPGTPase HRas/0.443
4ql3GDPGTPase KRas/0.441