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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nyiGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nyiGNPGTPase HRas/1.000
4nyjGNPGTPase HRas/0.638
3ddcGNPGTPase HRas/0.610
3v4fGNPGTPase HRas/0.609
3lbnGNPGTPase HRas/0.596
3oivGNPGTPase HRas/0.584
3rs5GNPGTPase HRas/0.581
4dltGNPGTPase HRas/0.576
3oiuGNPGTPase HRas/0.572
5dhaGNPGTP-binding nuclear protein Ran/0.572
5b2zGNPGTPase HRas/0.571
1zc3GNPRas-related protein Ral-A/0.569
4k81GTPGTPase HRas/0.569
1xtsGTPGTP-binding protein Rheb/0.566
3nbzGTPGTP-binding nuclear protein Ran/0.565
4dlwGNPGTPase HRas/0.565
1zc4GNPRas-related protein Ral-A/0.562
2rgcGNPGTPase HRas/0.562
2rgeGNPGTPase HRas/0.562
1kmqGNPTransforming protein RhoA/0.560
4kvgGTPRas-related protein Rap-1A/0.558
2rgbGNPGTPase HRas/0.557
3i3sGNPGTPase HRas/0.556
3tsoGNPRas-related protein Rab-25/0.553
3oesGNPGTPase RhebL1/0.552
1g17GNPRas-related protein SEC4/0.550
3kucGDPRas-related protein Rap-1A/0.550
1e96GTPRas-related C3 botulinum toxin substrate 1/0.549
2zetGTPRas-related protein Rab-27B/0.549
3e5hGNPRas-related protein Rab-28/0.549
3rabGNPRas-related protein Rab-3A/0.544
4qxaGTPRas-related protein Rab-9A/0.544
3a58GNPGTP-binding protein RHO1/0.543
3bbpGTPRas-related protein Rab-6A/0.543
4xvrGNPGTPase HRas/0.542
2c5lGTPGTPase HRas/0.540
4g0nGNPGTPase HRas/0.540
1ibrGNPGTP-binding nuclear protein Ran/0.539
1m7bGTPRho-related GTP-binding protein RhoE/0.539
4dlxGNPGTPase HRas/0.538
3l8yGNPGTPase HRas/0.537
1zbdGTPRas-related protein Rab-3A/0.533
4mitGTPRho-related protein racC/0.532
1lfdGNPGTPase HRas/0.531
4lhwGNPRas-related protein Rab-8A/0.531
3kkoGNPRas-related protein M-Ras/0.530
5jljGNPGTP-binding nuclear protein Ran/0.530
1cxzGSPTransforming protein RhoA/0.529
3a6pGTPGTP-binding nuclear protein Ran/0.529
3pitGNPRas-related protein M-Ras/0.529
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.528
2cl6CAGGTPase HRas/0.528
1a2bGSPTransforming protein RhoA/0.527
3k8yGNPGTPase HRas/0.527
4rkfGNPRas-related protein Rab-3/0.527
4dsnGCPGTPase KRas/0.524
3x1zGNPRas-related protein Rap-1b/0.523
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.522
3kudGDPGTPase HRas/0.522
4dlvGNPGTPase HRas/0.522
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.521
4dlzGNPGTPase HRas/0.521
3kz1GSPTransforming protein RhoA/0.520
1oixGDPRas-related protein Rab-11A/0.519
1xtrGNPGTP-binding protein Rheb/0.519
3rs7GNPGTPase HRas/0.519
1uadGNPRas-related protein Ral-A/0.516
1yzqGNPRas-related protein Rab-6A/0.516
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.516
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.516
4dxaGSPRas-related protein Rap-1b/0.516
2fe4GDPRas-related protein Rab-6B/0.515
5hpyGDPTransforming protein RhoA/0.515
3lbhGNPGTPase HRas/0.514
1t91GTPRas-related protein Rab-7a/0.513
3rs0GNPGTPase HRas/0.512
3w3zGTPGTP-binding nuclear protein Ran/0.512
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.511
4hdqGNPRas-related protein Rap-1b/0.511
3oiwGNPGTPase HRas/0.510
4xvqGNPGTPase HRas/0.508
4o25GTPGTP-binding protein Rheb/0.507
2clsGTPRho-related GTP-binding protein Rho6/0.506
2gilGTPRas-related protein Rab-6A/0.506
2rggGNPGTPase HRas/0.506
3tgpGNPGTPase HRas/0.506
5c46GSPRas-related protein Rab-11A/0.505
3ea5GDPGTP-binding nuclear protein Ran/0.503
1ow3GDPTransforming protein RhoA/0.500
2ffqGSPRas-related protein Rab-6B/0.500
3bc1GNPRas-related protein Rab-27A/0.499
3lawGNPRas-related protein Rab-7a/0.499
3lbiGNPGTPase HRas/0.499
4dsuGDPGTPase KRas/0.497
3rs4GNPGTPase HRas/0.495
4dsoGSPGTPase KRas/0.495
4tq9GDPGTPase KRas/0.495
4uj3GNPRas-related protein Rab-11A/0.495
2gcpGSPRho-related GTP-binding protein RhoC/0.493
3qbtGNPRas-related protein Rab-8A/0.493
3tklGTPRas-related protein Rab-1A/0.493
4ol0GTPGTP-binding nuclear protein Ran/0.493
3eg5GNPCell division control protein 42 homolog/0.491
1vg8GNPRas-related protein Rab-7a/0.490
3rslGNPGTPase HRas/0.490
4hdoGNPRas-related protein Rap-1b/0.489
4l9sGDPGTPase HRas/0.489
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.487
1s1cGNPTransforming protein RhoA/0.486
1yhnGTPRas-related protein Rab-7a/0.486
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.486
1k5dGNPGTP-binding nuclear protein Ran/0.485
3tnfGNPRas-related protein Rab-8A/0.485
4js0GNPCell division control protein 42 homolog/0.484
4lpkGDPGTPase KRas/0.484
4xoiGTPTransforming protein RhoA/0.480
1gwnGTPRho-related GTP-binding protein RhoE/0.479
4cymGCPRas-related protein Rab-32/0.479
1zd9GDPADP-ribosylation factor-like protein 8A/0.476
3th5GNPRas-related C3 botulinum toxin substrate 1/0.476
5difGNPGTP-binding nuclear protein Ran/0.476
4obeGDPGTPase KRas/0.475
2msdGNPMHC class I alpha chain/0.474
4lucGDPGTPase KRas/0.470
4lv6GDPGTPase KRas/0.470
3kkqGDPRas-related protein M-Ras/0.467
4epwGDPGTPase KRas/0.466
1z2cGNPRho-related GTP-binding protein RhoC/0.465
3cphGDPRas-related protein SEC4/0.463
2bkuGTPGTP-binding nuclear protein Ran/0.461
4dlsGNPGTPase HRas/0.461
4uj5GNPRas-related protein Rab-11A/0.459
4o2rGDPGTP-binding protein Rheb/0.458
4l9wGNPGTPase HRas/0.457
4wa7GDPGTPase KRas/0.457
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.454
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.453
2ce2GDPGTPase HRas/0.452
3x1wGDPRas-related protein Rap-1b/0.452
4q03GDPGTPase KRas/0.452
2fg5GNPRas-related protein Rab-31/0.451
4cidANPEH domain-containing protein 2/0.451
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.450
1ii6ADPKinesin-like protein KIF11/0.448
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.446
3wyfGTPGTP-binding nuclear protein/0.445
4o2lGTPGTP-binding protein Rheb/0.445
1tu3GNPRas-related protein Rab-5A/0.442
1z0aGDPRas-related protein Rab-2A/0.442
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.441
4q02GDPGTPase KRas/0.441
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.440