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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nu0AP5Adenylate kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nu0AP5Adenylate kinase/1.000
2oo7AP5Adenylate kinase/0.648
2osbAP5Adenylate kinase/0.636
3dl0AP5Adenylate kinase/0.636
4w5jAP5Adenylate kinase/0.634
4jldADPAdenylate kinase/0.632
4qbiAP5Adenylate kinase/0.629
4mkfAP5Adenylate kinase/0.623
3dkvAP5Adenylate kinase/0.621
3hpqAP5Adenylate kinase/0.617
2qajAP5Adenylate kinase/0.615
1akeAP5Adenylate kinase/0.614
4cf7ADPAdenylate kinase/0.612
2eu8AP5Adenylate kinase/0.606
4jloADPAdenylate kinase/0.604
4x8oAP5Adenylate kinase/0.590
4jl5ADPAdenylate kinase/0.586
1p3jAP5Adenylate kinase/0.578
2rgxAP5Adenylate kinase/0.567
4qbhAP5Adenylate kinase/0.566
1ankANPAdenylate kinase/0.562
1e4yAP5Adenylate kinase/0.561
4ikeADPAdenylate kinase/0.561
2eckADPAdenylate kinase/0.560
4jl6ADPAdenylate kinase/0.558
4jkyADPAdenylate kinase/0.553
1zioAP5Adenylate kinase/0.551
3tlxADPAdenylate kinase 2/0.548
4x8lAP5Adenylate kinase/0.547
2akyAP5Adenylate kinase/0.532
1e4vAP5Adenylate kinase/0.525
3p62FMNPentaerythritol tetranitrate reductase/0.507
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.504
2vbdV10Isopenicillin N synthase1.21.3.10.496
1xddAAYIntegrin alpha-L/0.492
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.492
2olrATPPhosphoenolpyruvate carboxykinase (ATP)/0.491
3lqfNADGalactitol dehydrogenase/0.491
1qjfACSIsopenicillin N synthase1.21.3.10.490
3s79ASDAromatase1.14.14.140.489
3uceNDPDehydrogenase/0.486
5k2bZMAAdenosine receptor A2a/0.486
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.485
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.485
1esvLARActin, alpha skeletal muscle/0.484
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.484
2c27ACOMycothiol acetyltransferase2.3.1.1890.484
2c29NAPDihydroflavonol 4-reductase/0.484
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.484
2v59LZKBiotin carboxylase6.3.4.140.483
3tqcADPPantothenate kinase/0.483
4dieC5PCytidylate kinase/0.483
1blzACVIsopenicillin N synthase1.21.3.10.482
5iu86DZAdenosine receptor A2a/0.482
1qiqACCIsopenicillin N synthase1.21.3.10.481
5jtbZMAAdenosine receptor A2a/0.481
1p4aPCPPur operon repressor/0.480
2qimZEAClass 10 plant pathogenesis-related protein/0.480
3mpt1GKMitogen-activated protein kinase 14/0.480
4lzwTHMUridine phosphorylase/0.480
2jb4A14Isopenicillin N synthase1.21.3.10.479
2pg0FADAcyl-CoA dehydrogenase/0.479
4idgNADPutative UDP-glucose 4-epimerase/0.479
1cjtFOKAdenylate cyclase type 2/0.477
1cjtFOKAdenylate cyclase type 5/0.477
1ytmATPPhosphoenolpyruvate carboxykinase (ATP)/0.477
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.476
3oibFDAPutative acyl-CoA dehydrogenase/0.475
4loh1SYStimulator of interferon genes protein/0.475
1obnASVIsopenicillin N synthase1.21.3.10.474
3mzhCMPCRP-like cAMP-activated global transcriptional regulator/0.474
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.474
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.473
2zshGA3Gibberellin receptor GID1A30.472
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.471
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.471
4d5gFADCyclohexane-1,2-dione hydrolase3.7.1.110.471
1fm4DXCMajor pollen allergen Bet v 1-L/0.470
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.470
2bunFADAppA protein/0.470
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.470
2y6fM9FIsopenicillin N synthase1.21.3.10.470
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.469
2ylrNAPPhenylacetone monooxygenase1.14.13.920.469
2zl9VDAVitamin D3 receptor/0.469
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.469
3zoiM2WIsopenicillin N synthase1.21.3.10.469
4kwhNAPReductase homolog/0.469
1bk0ACVIsopenicillin N synthase1.21.3.10.468
2vn0TDZCytochrome P450 2C8/0.468
2y60M8FIsopenicillin N synthase1.21.3.10.468
3cosNADAlcohol dehydrogenase 41.1.1.10.468
3up0D7SaceDAF-12/0.468
4oztP1AEcdysone receptor, putative/0.468
4xgxADPFAD:protein FMN transferase/0.468
1p0hACOMycothiol acetyltransferase2.3.1.1890.467
2iviACWIsopenicillin N synthase1.21.3.10.467
2vprTDCTetracycline repressor protein class H/0.467
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.467
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.467
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.466
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.466
3ik6HCZGlutamate receptor 2/0.466
3zkyWT4Isopenicillin N synthase1.21.3.10.466
4xguADPPutative pachytene checkpoint protein 2/0.466
2oapANPType II secretion system protein (GspE-2)/0.465
3fnlSHALactoperoxidase/0.465
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.465
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.465
5uviZMAAdenosine receptor A2a/0.465
2qo9ANPEphrin type-A receptor 32.7.10.10.464
1cg3IMOAdenylosuccinate synthetase/0.463
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.463
2vbpVB1Isopenicillin N synthase1.21.3.10.463
3s1dZIRCytokinin dehydrogenase 11.5.99.120.463
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4f5dC2EStimulator of interferon genes protein/0.463
4jlj1NMDeoxycytidine kinase2.7.1.740.463
4u0mGTPCyclic GMP-AMP synthase/0.463
1kp3ATPArgininosuccinate synthase6.3.4.50.462
1u1f183Uridine phosphorylase2.4.2.30.462
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.462
3p67FMNPentaerythritol tetranitrate reductase/0.462
3qlrNDPDihydrofolate reductase1.5.1.30.462
4l4xNDPAmphI/0.462
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.462
1bcpATPPertussis toxin subunit 4/0.461
1bcpATPPertussis toxin subunit 5/0.461
1txtCAAHMG-CoA synthase/0.461
1u1d181Uridine phosphorylase2.4.2.30.461
2j5xGSPADP-ribosylation factor 6/0.461
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
2vcmM11Isopenicillin N synthase1.21.3.10.461
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.461
4fryNADPutative signal-transduction protein with CBS domains/0.461
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.461
5iua6DXAdenosine receptor A2a/0.461
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.460
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.460
1x27ASP_TYR_VAL_HIS_PTRTyrosine-protein kinase Lck2.7.10.20.460
2gmjFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.460
2hb7O1CVitamin D3 receptor/0.460
3cbsR12Cellular retinoic acid-binding protein 2/0.460
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.460
3tdaPN0Cytochrome P450 2D6/0.460
4hjoAQ4Epidermal growth factor receptor2.7.10.10.460
4n9iPCGCatabolite expression activator/0.460
5cnsCDPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.460
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.460
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.460
1hb1OCVIsopenicillin N synthase1.21.3.10.459
2bu9HFVIsopenicillin N synthase1.21.3.10.459
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.459
3ed1GA3Gibberellin receptor GID1/0.459
3jzdNADMaleylacetate reductase/0.459
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
4fidGDPG protein alpha subunit, putative/0.459
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.459
4qvbF42F420H(2)-dependent reductase Rv11551.4.3.50.459
4qxp1YEStimulator of interferon genes protein/0.459
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.458
2omeNADC-terminal-binding protein 2/0.458
2wo7ASVIsopenicillin N synthase1.21.3.10.458
3b70NAPEnoyl reductase LovC10.458
3eblGA4Gibberellin receptor GID1/0.458
3gbuATPUncharacterized sugar kinase PH14592.7.10.458
4qms1N1Serine/threonine-protein kinase 242.7.11.10.458
1hb3SCVIsopenicillin N synthase1.21.3.10.457
1u1gBBBUridine phosphorylase2.4.2.30.457
2b69NADUDP-glucuronic acid decarboxylase 14.1.1.350.457
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.457
2tpsTPSThiamine-phosphate synthase/0.457
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.457
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.457
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.457
4dzzADPPlasmid partitioning protein ParF/0.457
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.457
5k2cZMAAdenosine receptor A2a/0.457
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.456
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.456
2dteNAIGlucose 1-dehydrogenase related protein/0.456
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.456
2rm2W43Genome polyprotein/0.456
2w06FRVCyclin-dependent kinase 22.7.11.220.456
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.456
3stw2TDMethylketone synthase I/0.456
3to6LYS_CMCHistone acetyltransferase ESA1/0.456
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
4qxr1YEStimulator of interferon genes protein/0.456
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.456
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.455
1snyNAPLD36273p/0.455
1uzwCDHIsopenicillin N synthase1.21.3.10.455
2cbsR13Cellular retinoic acid-binding protein 2/0.455
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.455
4b99R4LMitogen-activated protein kinase 72.7.11.240.455
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.455
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.454
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.454
1sq5ADPPantothenate kinase2.7.1.330.454
2o12FMNChorismate synthase/0.454
2x0iNAIMalate dehydrogenase/0.454
2zbaZBATrichothecene 3-O-acetyltransferase/0.454
3c15GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.454
3hk1B64Fatty acid-binding protein, adipocyte/0.454
3hl0NADMaleylacetate reductase/0.454
3o3pGDDGlycosyl transferase, family 2/0.454
3wb2YGPUncharacterized protein MJ0488/0.454
4bb3KKAIsopenicillin N synthase1.21.3.10.454
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.454
4hs4FMNChromate reductase/0.454
4zolGTPTubulin alpha-1B chain/0.454
1okkGCPSignal recognition particle protein/0.453
1okkGCPSignal recognition particle receptor FtsY/0.453
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1udaUFGUDP-glucose 4-epimerase5.1.3.20.453
1udcUFMUDP-glucose 4-epimerase5.1.3.20.453
1v9aSAHUncharacterized protein/0.453
1w06W05Isopenicillin N synthase1.21.3.10.453
2cduFADNADH oxidase/0.453
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
2gn4UD1UDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.453
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.453
3buzLARActin, alpha skeletal muscle/0.453
3c3xNAPEugenol synthase 11.1.1.3180.453
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
3oq6NAJAlcohol dehydrogenase E chain1.1.1.10.453
4ki0ANPMaltose/maltodextrin import ATP-binding protein MalK/0.453
4qxq1YEStimulator of interferon genes protein/0.453
4rww2BALmo2692 protein/0.453
4x30T44Thyroxine-binding globulin/0.453
4yswFADXanthine dehydrogenase/oxidase/0.453
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.453
5dbyNPSSerum albumin/0.453
4xnw2IDP2Y purinoceptor 1/0.453
1gveNAPAflatoxin B1 aldehyde reductase member 310.452
1jpaANPEphrin type-B receptor 22.7.10.10.452
3flwFLWMitogen-activated protein kinase 14/0.452
3fmh533Mitogen-activated protein kinase 14/0.452
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.452
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
4f9fGDPPutative glycosyltransferase/0.452
4jc51K5Stimulator of interferon genes protein/0.452
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.452
4wfr2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.452
5ftcADPTPR domain protein/0.452
5hs1VORLanosterol 14-alpha demethylase/0.452
5iqeGNPBifunctional AAC/APH2.3.10.452
1f9aATPNicotinamide-nucleotide adenylyltransferase/0.451
1lrkUD1UDP-glucose 4-epimerase5.1.3.20.451
1oc1ASVIsopenicillin N synthase1.21.3.10.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
3dxmN24Actin-related protein 3/0.451
3mvm39PMitogen-activated protein kinase 14/0.451
4dc0NDPPutative ketoacyl reductase1.3.10.451
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.451
4r43GDPPhosphoenolpyruvate carboxykinase [GTP]/0.451
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
5kgpACOPredicted acetyltransferase/0.451
1ie9VDXVitamin D3 receptor/0.450
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.450
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.450
1ptjSNDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.450
1qvnFRIInterleukin-2/0.450
1t2cNAIL-lactate dehydrogenase1.1.1.270.450
2bl4NADLactaldehyde reductase1.1.1.770.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.450
2y3pSM8DNA gyrase subunit A/0.450
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
3w32W32Epidermal growth factor receptor2.7.10.10.450
4bqwQNMEgl nine homolog 1/0.450
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.450
4g7gVFVLanosterol 14-alpha-demethylase/0.450
4i02CMPcAMP-activated global transcriptional regulator CRP/0.450
4wouGDPPhosphoenolpyruvate carboxykinase [GTP]/0.450
5iu4ZMAAdenosine receptor A2a/0.450
1g1aNADdTDP-glucose 4,6-dehydratase/0.449
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.449
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.449
1tgv5UDUridine phosphorylase2.4.2.30.449
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.449
2g1m4HGEgl nine homolog 1/0.449
2p5uNADUDP-glucose 4-epimerase/0.449
2vhzNAIAlanine dehydrogenase1.4.1.10.449
2wdzNADGalactitol dehydrogenase/0.449
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.449
3phiNDPShikimate dehydrogenase (NADP(+))/0.449
3wdsNADNADH-dependent quinuclidinone reductase/0.449
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.449
4xj3GTPCyclic GMP-AMP synthase/0.449
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.449
4zohFADPutative oxidoreductase FAD-binding subunit/0.449
5iubCLRAdenosine receptor A2a/0.449
1cdoNADAlcohol dehydrogenase 11.1.1.10.448
1dr3TAPDihydrofolate reductase1.5.1.30.448
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
1nhhANPDNA mismatch repair protein MutL/0.448
1nzdUPGDNA beta-glucosyltransferase/0.448
1pq944BOxysterols receptor LXR-beta/0.448
1rfuADPPyridoxal kinase2.7.1.350.448
1rp0AHZThiamine thiazole synthase, chloroplastic/0.448
2a84ATPPantothenate synthetase6.3.2.10.448
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2eixFADNADH-cytochrome b5 reductase/0.448
2gfsPQBMitogen-activated protein kinase 14/0.448
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2q4bNAPUncharacterized protein At5g02240/0.448
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.448
3iphG11Mitogen-activated protein kinase 14/0.448
3lfcZ86Mitogen-activated protein kinase 14/0.448
3pzcCOAAmino acid--[acyl-carrier-protein] ligase 16.2.1.n20.448
3uylTYDProbable NDP-rhamnosyltransferase/0.448
4c77N01Phenylacetone monooxygenase1.14.13.920.448
4p13FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.448
5d3qGDPDynamin-13.6.5.50.448
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.448
12gs0HHGlutathione S-transferase P2.5.1.180.447
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.447
1cqp803Integrin alpha-L/0.447
1dj2GDPAdenylosuccinate synthetase, chloroplastic/0.447
1joaFADNADH peroxidase1.11.1.10.447
1k21IGNProthrombin3.4.21.50.447
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.447
2g78REACellular retinoic acid-binding protein 2/0.447
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.447
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.447
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.447
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
2ym2FADPhenylacetone monooxygenase1.14.13.920.447
3clrFADElectron transfer flavoprotein subunit alpha/0.447
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.447
3vglANPGlucokinase/0.447
3wv9FEGHmd co-occurring protein HcgE/0.447
4eiyZMAAdenosine receptor A2a/0.447
4kip1R9Mitogen-activated protein kinase 14/0.447
7stdCRPScytalone dehydratase4.2.1.940.447
5k2aZMAAdenosine receptor A2a/0.447
1adfTADAlcohol dehydrogenase E chain1.1.1.10.446
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.446
1goxFMNPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.446
1ie8KH1Vitamin D3 receptor/0.446
1kh3ANPArgininosuccinate synthase/0.446
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.446
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.446
2c92TP66,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2gqtFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.446
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.446
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.446
2yphQQY2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
2yutNAPPutative short-chain oxidoreductase/0.446
3dmeFADPutative conserved exported protein/0.446
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.446
3mgdACOPredicted acetyltransferase/0.446
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.446
3v49PK0Androgen receptor/0.446
3vt65YIVitamin D3 receptor/0.446
4hxyNDPPlm1/0.446
4in44IDKelch-like ECH-associated protein 1/0.446
4kin1M8Mitogen-activated protein kinase 14/0.446
4m5pFMNNADPH dehydrogenase/0.446
4okx198Androgen receptor/0.446
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.446
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.446
1amoNAPNADPH--cytochrome P450 reductase/0.445
1bsvNDPGDP-L-fucose synthase/0.445
1cg0IMOAdenylosuccinate synthetase/0.445
1hetNADAlcohol dehydrogenase E chain1.1.1.10.445
1lkeDOGBilin-binding protein/0.445
1mj9COAHistone acetyltransferase ESA1/0.445
1vfrFMNMajor NAD(P)H-flavin oxidoreductase1.6.990.445
2hfuMEVMevalonate kinase/0.445
2v5aLZLBiotin carboxylase6.3.4.140.445
2vttLZDCyclin-dependent kinase 22.7.11.220.445
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.445
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
3fql79ZGenome polyprotein2.7.7.480.445
3iej599Cathepsin S3.4.22.270.445
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.445
3poz03PEpidermal growth factor receptor2.7.10.10.445
3qe2NAPNADPH--cytochrome P450 reductase/0.445
3zbsOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4a81DXCMajor pollen allergen Bet v 1-A/0.445
4cj4S3GIntegrase/0.445
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.445
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.445
4l8u9AZSerum albumin/0.445
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.445
4uj5GNPRas-related protein Rab-11A/0.445
4yaiNAIC alpha-dehydrogenase/0.445
5iqhGNPBifunctional AAC/APH2.3.10.445
1icsFMN12-oxophytodienoate reductase 11.3.1.420.444
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1qf5RPLAdenylosuccinate synthetase/0.444
1vceSAHDiphthine synthase/0.444
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.444
2jn3JN3Fatty acid-binding protein, liver/0.444
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.444
2x0rNADMalate dehydrogenase/0.444
3f03FMNPentaerythritol tetranitrate reductase/0.444
3mw9NAIGlutamate dehydrogenase 1, mitochondrial1.4.1.30.444
3p74FMNPentaerythritol tetranitrate reductase/0.444
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.444
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.444
3qe0GDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.444
3r9iADPSeptum site-determining protein MinD/0.444
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.444
3uyt0CKCasein kinase I isoform delta2.7.11.10.444
4d04NAPPhenylacetone monooxygenase1.14.13.920.444
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4isk1JYThymidylate synthase/0.444
4q71FADBifunctional protein PutA/0.444
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1ef92CPMethylmalonyl-CoA decarboxylase4.1.1.410.443
1i2lDCSAminodeoxychorismate lyase4.1.3.380.443
1ipeNDPTropinone reductase 21.1.1.2360.443
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.443
1xelUPGUDP-glucose 4-epimerase5.1.3.20.443
2briANPUridylate kinase2.7.4.220.443
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.443
2ojg19AMitogen-activated protein kinase 12.7.11.240.443
2vouFAD2,6-dihydroxypyridine 3-monooxygenase1.14.13.100.443
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.443
2x7hPFNProstaglandin reductase 310.443
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
2z50028Geranylgeranyl pyrophosphate synthase/0.443
2znq401Peroxisome proliferator-activated receptor delta/0.443
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.443
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.443
3n8nN883-dehydroquinate dehydratase4.2.1.100.443
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.443
4ambDUDPutative glycosyl transferase/0.443
4c4oNADSADH/0.443
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.443
4irnFADAnaB/0.443
4yp12BAStimulator of interferon genes protein/0.443
5ahsFADAcyl-CoA dehydrogenase/0.443
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.443
5kjeNAJAlcohol dehydrogenase E chain1.1.1.10.443
1caqDPSStromelysin-13.4.24.170.442
1cbqRE9Cellular retinoic acid-binding protein 2/0.442
1jueFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.442
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.442
1lluNADAlcohol dehydrogenase/0.442
1m78NDPDihydrofolate reductase1.5.1.30.442
1ma0NADAlcohol dehydrogenase class-31.1.1.10.442
1n5dNDPCarbonyl reductase [NADPH] 1/0.442
1pqc444Oxysterols receptor LXR-beta/0.442
1rkxNADCDP-D-glucose-4,6-dehydratase/0.442
2ek2SAHDiphthine synthase/0.442
2h59APRNAD-dependent protein deacetylase/0.442
2hveADPNucleoside diphosphate kinase A2.7.4.60.442
2jh5895Prothrombin3.4.21.50.442
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.442
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.442
2rs1W84Genome polyprotein/0.442
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.442
3djjFADGlutathione reductase, mitochondrial1.8.1.70.442
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.442
3kb6NADD-lactate dehydrogenase/0.442
3nmpPYVAbscisic acid receptor PYL2/0.442
3r83Z14Cyclin-dependent kinase 22.7.11.220.442
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.442
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.442
4aa4QC0Mitogen-activated protein kinase 14/0.442
4aa5NQBMitogen-activated protein kinase 14/0.442
4ajj88RL-lactate dehydrogenase A chain1.1.1.270.442
4g2fC07Ephrin type-A receptor 32.7.10.10.442
4k28NADShikimate dehydrogenase family protein/0.442
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.442
4yswNAIXanthine dehydrogenase/oxidase/0.442
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.442
17gsGTXGlutathione S-transferase P2.5.1.180.441
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1dliUDXUDP-glucose 6-dehydrogenase/0.441
1dr2TAPDihydrofolate reductase1.5.1.30.441
1oonFMNOxygen-insensitive NAD(P)H nitroreductase/0.441
1pgtGTXGlutathione S-transferase P2.5.1.180.441
1tehNADAlcohol dehydrogenase class-31.1.1.10.441
1udbUFGUDP-glucose 4-epimerase5.1.3.20.441
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.441
2iypA2P6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.441
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.441
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.441
2od7A1RNAD-dependent protein deacetylase HST23.5.10.441
2pj4414Carboxypeptidase B/0.441
2uxwTH3Very long-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.90.441
2vwqNAPGlucose 1-dehydrogenase/0.441
2wtkANPSTE20-related kinase adapter protein alpha/0.441
2x3jATPAcsD/0.441
2x4zX4ZSerine/threonine-protein kinase PAK 42.7.11.10.441
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3eufBAUUridine phosphorylase 1/0.441
3flzFLZMitogen-activated protein kinase 14/0.441
3h86AP5Adenylate kinase/0.441
3kb1ADPIron-sulfur cluster carrier protein/0.441
3mqe416Prostaglandin G/H synthase 21.14.99.10.441
3o26NDPSalutaridine reductase/0.441
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.441
3tlkEB4Ferrienterobactin-binding periplasmic protein/0.441
3u8l09QAcetylcholine-binding protein/0.441
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.441
4emtC2EStimulator of interferon genes protein/0.441
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.441
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4g73NAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.441
4jx1CAHCamphor 5-monooxygenase1.14.15.10.441
4k36SAMAnaerobic sulfatase-maturating enzyme1.8.980.441
4looSB4Mitogen-activated protein kinase 14/0.441
4mlp2CXCryptochrome-2/0.441
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.441
4wdgA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
4y9lFADAcyl-CoA dehydrogenase family member 11/0.441
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.441
5k2dZMAAdenosine receptor A2a/0.441
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.440
1i59ANPChemotaxis protein CheA2.7.13.30.440
1ie3NADMalate dehydrogenase/0.440
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.440
1tduDURThymidylate synthase/0.440
2abbFMNPentaerythritol tetranitrate reductase/0.440
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.440
2bxmIMNSerum albumin/0.440
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.440
2ejzSAHDiphthine synthase/0.440
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.440
2g9uG27Glycogen phosphorylase, muscle form2.4.1.10.440
2jlbUDMUncharacterized protein/0.440
2qbmCAMCamphor 5-monooxygenase1.14.15.10.440
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.440
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.440
2zpaADPtRNA(Met) cytidine acetyltransferase TmcA/0.440
3b2sB2STrichothecene 3-O-acetyltransferase/0.440
3epoMP5Phosphomethylpyrimidine synthase/0.440
3ieuGDPGTPase Era/0.440
3kjgADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.440
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3rimTPPTransketolase2.2.1.10.440
4a83DXCMajor pollen allergen Bet v 1-A/0.440
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.440
4hdhATPGenome polyprotein2.7.7.480.440
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4kbyC2EStimulator of interferon genes protein/0.440
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440
4loi1YCStimulator of interferon genes protein/0.440
4rheFMNFlavin prenyltransferase UbiX/0.440
4ww0ADPATP-dependent zinc metalloprotease FtsH/0.440
4z0g5GPInosine-5'-monophosphate dehydrogenase/0.440
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.440
5kgjACOPredicted acetyltransferase/0.440