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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nm9FADBifunctional protein PutA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nm9FADBifunctional protein PutA/1.000
4nmbFADBifunctional protein PutA/0.649
4nmdFDABifunctional protein PutA/0.647
4o8aFADBifunctional protein PutA1.2.1.880.587
4q72FADBifunctional protein PutA/0.572
1tj2FADBifunctional protein PutA1.5.5.20.571
3e2sFADBifunctional protein PutA1.5.5.20.571
4q73FADBifunctional protein PutA/0.561
1tj0FADBifunctional protein PutA1.5.5.20.550
1tj1FADBifunctional protein PutA1.5.5.20.550
2fznFADBifunctional protein PutA1.5.5.20.545
4q71FADBifunctional protein PutA/0.540
2fzmFADBifunctional protein PutA1.5.5.20.526
3hazFADBifunctional protein PutA/0.518
2j9gANPBiotin carboxylase6.3.4.140.474
2qblCAMCamphor 5-monooxygenase1.14.15.10.474
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.472
3lqfNADGalactitol dehydrogenase/0.468
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.468
4enhFVXCholesterol 24-hydroxylase/0.466
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
1nooCAHCamphor 5-monooxygenase1.14.15.10.463
3l63CAMCamphor 5-monooxygenase1.14.15.10.463
2jn3JN3Fatty acid-binding protein, liver/0.462
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.462
3bg7FADPyranose 2-oxidase/0.461
1t86CAMCamphor 5-monooxygenase1.14.15.10.459
1t88CAMCamphor 5-monooxygenase1.14.15.10.459
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.459
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.459
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.458
3fwjCAMCamphor 5-monooxygenase1.14.15.10.458
3vt8YI3Vitamin D3 receptor/0.458
3fwfCAMCamphor 5-monooxygenase1.14.15.10.456
3vt7VDXVitamin D3 receptor/0.455
1t87CAMCamphor 5-monooxygenase1.14.15.10.454
2c3qGTXGlutathione S-transferase theta-12.5.1.180.453
3wrlCAMCamphor 5-monooxygenase1.14.15.10.453
5hsaFASAlcohol oxidase 11.1.3.130.452
1rfvADPPyridoxal kinase2.7.1.350.451
3drcMTXDihydrofolate reductase1.5.1.30.451
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
3a783EVVitamin D3 receptor/0.450
1jpaANPEphrin type-B receptor 22.7.10.10.449
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
1rfuADPPyridoxal kinase2.7.1.350.448
3h3r14HCollagen type IV alpha-3-binding protein/0.448
4tuvCPZCytochrome P450 1191.140.448
6cp4CAMCamphor 5-monooxygenase1.14.15.10.448
1dz8CAMCamphor 5-monooxygenase1.14.15.10.447
1iwjCAMCamphor 5-monooxygenase1.14.15.10.447
2vn0TDZCytochrome P450 2C8/0.447
4dc0NDPPutative ketoacyl reductase1.3.10.447
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4k6fNAPPutative Acetoacetyl-CoA reductase/0.447
4nc3ERM5-hydroxytryptamine receptor 2B/0.447
3tjzGNPADP-ribosylation factor 1/0.446
3vt9YI4Vitamin D3 receptor/0.446
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.446
4q0a4OAVitamin D3 receptor A/0.446
3wrjCAMCamphor 5-monooxygenase1.14.15.10.445
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.444
3gfbNADL-threonine 3-dehydrogenase/0.444
3r7eX88Cyclin-dependent kinase 22.7.11.220.444
4ek1CAMCamphor 5-monooxygenase1.14.15.10.444
4iteTEYVitamin D3 receptor/0.444
4iva1J5Tyrosine-protein kinase JAK2/0.444
5a3bAPRSIR2 family protein/0.444
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.443
1uy8PU5Heat shock protein HSP 90-alpha/0.443
1yrdCAMCamphor 5-monooxygenase1.14.15.10.443
1u54ACPActivated CDC42 kinase 1/0.442
2zbaZBATrichothecene 3-O-acetyltransferase/0.442
3fwgCAMCamphor 5-monooxygenase1.14.15.10.442
3lxiCAMCytochrome P450/0.442
3nr4PYVAbscisic acid receptor PYL2/0.442
3t3r9PLCytochrome P450 2A61.14.130.442
3v9y24LPeroxisome proliferator-activated receptor gamma/0.442
1ddsMTXDihydrofolate reductase1.5.1.30.441
2zaxCAMCamphor 5-monooxygenase1.14.15.10.441
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440
2a1nCAMCamphor 5-monooxygenase1.14.15.10.440