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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.261.000
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.714
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.628
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.628
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.554
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.521
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.520
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.520
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.511
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.508
3du8553Glycogen synthase kinase-3 beta2.7.11.260.503
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.500
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.497
2qo9ANPEphrin type-A receptor 32.7.10.10.496
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.495
4riyADPEpidermal growth factor receptor2.7.10.10.495
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.490
4ii5ADPCyclin-dependent kinase 22.7.11.220.490
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.489
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.487
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.486
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.486
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.485
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.484
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.480
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.479
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.475
1gy3ATPCyclin-dependent kinase 22.7.11.220.473
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
2py3ACPFibroblast growth factor receptor 2/0.469
1qmzATPCyclin-dependent kinase 22.7.11.220.464
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.464
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.463
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.463
4bbe3O4Tyrosine-protein kinase JAK2/0.463
4wboANWRhodopsin kinase/0.463
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.462
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.460
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.460
4jrnANPRhoptry kinase family protein/0.459
1hk3T44Serum albumin/0.458
2cchATPCyclin-dependent kinase 22.7.11.220.456
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.455
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.455
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.454
4qnyANPMitogen activated protein kinase, putative/0.454
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
4qmlANPSerine/threonine-protein kinase 242.7.11.10.453
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.452
2xyuQ9GEphrin type-A receptor 42.7.10.10.451
3oriAGSSerine/threonine protein kinase/0.451
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.450
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.450
3qc9ADPRhodopsin kinase/0.450
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.450
1m17AQ4Epidermal growth factor receptor2.7.10.10.449
2pmlANPUncharacterized protein/0.449
4j95ACPFibroblast growth factor receptor 2/0.448
1lp4ANPCasein kinase II subunit alpha2.7.11.10.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.446
2pzpACPFibroblast growth factor receptor 2/0.446
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.446
2pz5ACPFibroblast growth factor receptor 2/0.445
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.445
2bxnIDBSerum albumin/0.444
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.444
4bgg844Activin receptor type-12.7.11.300.444
2qo7ANPEphrin type-A receptor 32.7.10.10.443
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.443
4i3zADPCyclin-dependent kinase 22.7.11.220.443
2bxiAZQSerum albumin/0.442
2c6eHPMAurora kinase A2.7.11.10.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.442
3c4wATPRhodopsin kinase/0.442
3wowANPCasein kinase II subunit alpha2.7.11.10.442
4eooATPCyclin-dependent kinase 22.7.11.220.441
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.440
3k5uPFQAurora kinase A2.7.11.10.440
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.440