sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 1.000 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.757 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.680 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.642 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.581 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.567 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.561 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.542 | |
| 4ros | APR | Malate dehydrogenase | / | 0.535 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.531 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.530 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.517 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.513 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.511 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.510 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.508 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.507 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.506 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.505 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.504 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.503 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.501 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.500 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.499 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.497 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.496 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.496 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.494 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.493 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.490 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.490 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.490 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.489 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.488 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.488 | |
| 4qec | NAP | ElxO | / | 0.487 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.484 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.484 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.484 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.483 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.481 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.481 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.481 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.480 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.480 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.479 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.479 | |
| 1ez4 | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.477 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.477 | |
| 5mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.477 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.476 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.476 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.476 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.475 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.475 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.475 | |
| 5a3b | APR | SIR2 family protein | / | 0.475 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.474 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.474 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.473 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.473 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.472 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.472 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.472 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.472 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.471 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.471 | |
| 3eku | CY9 | Actin-5C | / | 0.471 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.471 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.471 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.471 | |
| 3a3g | DLZ | Lumazine protein | / | 0.470 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.470 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.469 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.468 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.468 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.467 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.467 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.467 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.466 | |
| 3h3f | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.466 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.466 | |
| 4bls | APC | NTPase P4 | / | 0.466 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.466 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.465 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.465 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.464 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.464 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.464 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.464 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.464 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.463 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.463 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.463 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.463 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.463 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.463 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.462 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.462 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.462 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.462 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.461 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.461 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.461 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.461 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.461 | |
| 1emd | NAD | Malate dehydrogenase | / | 0.460 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.460 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.460 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.460 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.460 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.460 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.460 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.460 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.460 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.460 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.460 | |
| 5a3c | NAD | SIR2 family protein | / | 0.460 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.459 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.459 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.459 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.459 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.459 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.458 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.458 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.457 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.457 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.457 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.457 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.457 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.457 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 1eio | GCH | Gastrotropin | / | 0.456 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.456 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.456 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.456 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.456 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.456 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.456 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.456 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.455 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.455 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.455 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.455 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1b8u | NAD | Malate dehydrogenase | / | 0.454 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.454 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.454 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.454 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.454 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.454 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.454 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.454 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.453 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.453 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.453 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.453 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.453 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.453 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.453 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.453 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.452 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.452 | |
| 1xny | BTN | Propionyl-CoA carboxylase complex B subunit | / | 0.451 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.451 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.451 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.451 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.451 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.450 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.450 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.450 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.450 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.450 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.449 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.449 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.449 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.449 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3ieu | GDP | GTPase Era | / | 0.449 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.448 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.448 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.448 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.448 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.448 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.448 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.448 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.448 | |
| 3v2u | ATP | Protein GAL3 | / | 0.448 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.448 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.448 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.448 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.447 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.447 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.447 | |
| 2ohv | NHL | Glutamate racemase | / | 0.447 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.447 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.447 | |
| 4f4q | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.447 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.447 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.447 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.446 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.446 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.446 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.446 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.446 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.446 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.446 | |
| 4kwh | NAP | Reductase homolog | / | 0.446 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.445 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.445 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.445 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.445 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.445 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.445 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.445 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.444 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.444 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.444 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.444 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.444 | |
| 3pw8 | ACO | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.444 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3suf | SUE | Polyprotein | / | 0.444 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.444 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.444 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.443 | |
| 2djx | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.443 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.443 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.443 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.443 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.443 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.443 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.443 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.442 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.442 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2vjm | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.442 | |
| 2y3r | TRK | TamL | / | 0.442 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.442 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.442 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.442 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.441 | |
| 1gqt | ACP | Ribokinase | / | 0.441 | |
| 1ib6 | NAD | Malate dehydrogenase | / | 0.441 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.441 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.441 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 3e8x | NAP | BH1520 protein | / | 0.441 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.441 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.441 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.441 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 5dp2 | NAP | CurF | / | 0.441 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.441 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.440 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.440 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.440 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.440 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4jic | FMN | GTN Reductase | / | 0.440 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.440 | |
| 5ftf | ADP | TPR domain protein | / | 0.440 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.440 |