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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nbl2J6Caspase-63.4.22.59

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4nbl2J6Caspase-63.4.22.591.000
4nbn2J7Caspase-63.4.22.590.651
1jqdSAHHistamine N-methyltransferase2.1.1.80.491
1odcA8BAcetylcholinesterase3.1.1.70.479
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.473
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.471
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.471
1pd9CO4Dihydrofolate reductase1.5.1.30.466
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.466
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.466
1thnADPAnti-sigma F factor/0.464
2aotSAHHistamine N-methyltransferase2.1.1.80.459
1r8qAFBCytohesin-2/0.457
1r8qAFBADP-ribosylation factor 1/0.457
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.457
1klmSPPGag-Pol polyprotein2.7.7.490.452
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
2cleF6FTryptophan synthase alpha chain/0.452
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.451
4psbGA3Cytokinin-specific binding protein/0.451
1o5rFR9Adenosine deaminase3.5.4.40.449
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.449
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.448
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.448
1drfFOLDihydrofolate reductase1.5.1.30.446
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4qa2SHHHistone deacetylase 83.5.1.980.445
2bjsACVIsopenicillin N synthase1.21.3.10.444
2y6fM9FIsopenicillin N synthase1.21.3.10.444
4g1nNZTPyruvate kinase PKM2.7.1.400.444
3drcMTXDihydrofolate reductase1.5.1.30.443
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.443
4b5nFMNNAD(P)H:flavin oxidoreductase Sye4/0.443
3lfeZ84Mitogen-activated protein kinase 14/0.442
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.442
1yc2NADNAD-dependent protein deacylase 2/0.441
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3t8xT8XT-cell surface glycoprotein CD1b/0.440