sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 | 1.000 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.642 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.630 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.615 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.611 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.606 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.590 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.590 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.587 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.582 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.576 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.556 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.552 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.548 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.540 | |
| 2w6m | OA1 | Biotin carboxylase | 6.3.4.14 | 0.532 | |
| 1dv2 | ATP | Biotin carboxylase | 6.3.4.14 | 0.526 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.522 | |
| 2w6n | OA2 | Biotin carboxylase | 6.3.4.14 | 0.500 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.496 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.495 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.489 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.486 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.482 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.482 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.482 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.481 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.479 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.478 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.478 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.478 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.477 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.477 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.476 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.474 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.474 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.474 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.473 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.472 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.472 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.472 | |
| 3cse | N22 | Uncharacterized protein | / | 0.471 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.471 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.470 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.470 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.469 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.468 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.467 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.467 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.467 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.465 | |
| 1osv | CHC | Bile acid receptor | / | 0.465 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 1ej2 | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.464 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.464 | |
| 2iw6 | QQ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.464 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.464 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.464 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.464 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 1eio | GCH | Gastrotropin | / | 0.463 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.463 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.463 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.463 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.462 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.461 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.461 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.461 | |
| 3lnb | COA | N-acetyltransferase family protein | / | 0.461 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3pn1 | IVH | DNA ligase | / | 0.460 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.460 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.460 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.459 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.459 | |
| 2jfa | RAL | Estrogen receptor | / | 0.459 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.459 | |
| 2rbe | ZMG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.459 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.459 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 3lu8 | IQX | Serum albumin | / | 0.459 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.459 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.459 | |
| 4l8u | 9AZ | Serum albumin | / | 0.459 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.458 | |
| 2ad5 | ADP | CTP synthase | / | 0.458 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.458 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.457 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.457 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.456 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 1z1f | STL | Resveratrol synthase | / | 0.456 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.456 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.456 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.456 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3q5d | GDP | Atlastin-1 | 3.6.5 | 0.456 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.456 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.456 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1f28 | UMP | Thymidylate synthase | 2.1.1.45 | 0.455 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.455 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.455 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.455 | |
| 3wo0 | ADP | Alanine--anticapsin ligase | / | 0.455 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.455 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.454 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.454 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.454 | |
| 2y67 | N21 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.454 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.454 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.454 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.453 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.453 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2fna | ADP | Uncharacterized protein | / | 0.453 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.453 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.453 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.453 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3zy6 | GFB | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.453 | |
| 4a51 | DQ8 | Kinesin-like protein KIF11 | / | 0.453 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4nte | FAD | DepH | / | 0.453 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.453 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.452 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.452 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.451 | |
| 2apc | UDM | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.451 | |
| 2nom | DUT | Poly(A) polymerase, putative | / | 0.451 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.451 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4hh0 | FMN | AppA protein | / | 0.451 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.451 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.451 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.451 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.450 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2bun | FAD | AppA protein | / | 0.450 | |
| 2xsz | ATP | RuvB-like 2 | 3.6.4.12 | 0.450 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.450 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.450 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.449 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.449 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.449 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.448 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.448 | |
| 3n4m | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.448 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.448 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.448 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 5bpf | ADP | D-alanine--D-alanine ligase | / | 0.448 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.448 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.447 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.447 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.447 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.447 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.447 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.447 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 1b4p | GPS | Glutathione S-transferase Mu 2 | / | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 2e8w | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.446 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3ukr | CKH | Actin-related protein 3 | / | 0.446 | |
| 3ukr | CKH | Actin-related protein 2 | / | 0.446 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.446 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.446 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.446 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.446 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.445 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.445 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.445 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.445 | |
| 2hl1 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.445 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.445 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.445 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.445 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3rdq | DTB | Streptavidin | / | 0.445 | |
| 3zmm | F9J | Tyrosine-protein kinase JAK2 | / | 0.445 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.445 | |
| 4inb | 1F6 | Gag protein | / | 0.445 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.445 | |
| 4o4i | ACP | Tubulin tyrosine ligase | / | 0.445 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.444 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.444 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.444 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2db3 | ANP | ATP-dependent RNA helicase vasa, isoform A | 3.6.4.13 | 0.444 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.444 | |
| 2xvv | 9DN | Serum albumin | / | 0.444 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.444 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.444 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.444 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 4pk4 | ADP | Unconventional myosin-VI | / | 0.444 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.443 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.443 | |
| 1l9k | SAH | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.443 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.443 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.443 | |
| 3w2w | ATP | CRISPR system Cmr subunit Cmr2 | / | 0.443 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.443 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.443 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.443 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.443 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.442 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.442 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.442 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.442 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 2vag | V25 | Dual specificity protein kinase CLK1 | 2.7.12.1 | 0.442 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.442 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 3qly | 55V | Uncharacterized protein | / | 0.442 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.442 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 4l9q | 9TP | Serum albumin | / | 0.442 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.441 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1pgt | GTX | Glutathione S-transferase P | 2.5.1.18 | 0.441 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.441 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.441 | |
| 2i5n | UQ1 | Reaction center protein L chain | / | 0.441 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.441 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.441 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.441 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.441 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.441 | |
| 4lvg | 20O | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.441 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.441 | |
| 4ogr | ADN | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.441 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.440 | |
| 1vyw | 292 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.440 | |
| 2v1x | ADP | ATP-dependent DNA helicase Q1 | 3.6.4.12 | 0.440 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.440 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.440 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.440 | |
| 3mia | ANP | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.440 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.440 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.440 |