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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.11.000
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.614
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.474
3be9P04Casein kinase II subunit alpha2.7.11.10.470
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.467
3rk708ZCyclin-dependent kinase 22.7.11.220.460
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.459
3rak03ZCyclin-dependent kinase 22.7.11.220.457
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.457
1aq1STUCyclin-dependent kinase 22.7.11.220.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.454
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.450
4qmySTUSerine/threonine-protein kinase 242.7.11.10.449
2vagV25Dual specificity protein kinase CLK12.7.12.10.446
2c6tDT5Cyclin-dependent kinase 22.7.11.220.445
2cchATPCyclin-dependent kinase 22.7.11.220.445
1gih1PUCyclin-dependent kinase 22.7.11.220.444
2wihP48Cyclin-dependent kinase 22.7.11.220.444
2iw84SPCyclin-dependent kinase 22.7.11.220.443
2iw94SPCyclin-dependent kinase 22.7.11.220.443
4jqeANPCasein kinase II subunit alpha2.7.11.10.443
3qu0X40Cyclin-dependent kinase 22.7.11.220.442
3uli1N3Cyclin-dependent kinase 22.7.11.220.442
2uzeC95Cyclin-dependent kinase 22.7.11.220.441
2w17I19Cyclin-dependent kinase 22.7.11.220.441
3r9dX6BCyclin-dependent kinase 22.7.11.220.441
3rk507ZCyclin-dependent kinase 22.7.11.220.441
4btjATPTau-tubulin kinase 12.7.11.10.440