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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4mitGTPRho-related protein racC

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4mitGTPRho-related protein racC/1.000
3a6pGTPGTP-binding nuclear protein Ran/0.571
1zbdGTPRas-related protein Rab-3A/0.563
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.560
3kz1GSPTransforming protein RhoA/0.558
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.555
4k81GTPGTPase HRas/0.554
4ol0GTPGTP-binding nuclear protein Ran/0.550
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.548
3oiuGNPGTPase HRas/0.547
2gilGTPRas-related protein Rab-6A/0.546
3a58GNPGTP-binding protein RHO1/0.543
3oivGNPGTPase HRas/0.540
3w3zGTPGTP-binding nuclear protein Ran/0.538
1xtsGTPGTP-binding protein Rheb/0.537
5dhaGNPGTP-binding nuclear protein Ran/0.537
1e96GTPRas-related C3 botulinum toxin substrate 1/0.536
3lbnGNPGTPase HRas/0.536
3v4fGNPGTPase HRas/0.534
3rs7GNPGTPase HRas/0.533
1g17GNPRas-related protein SEC4/0.530
3ddcGNPGTPase HRas/0.530
5jljGNPGTP-binding nuclear protein Ran/0.529
3nbzGTPGTP-binding nuclear protein Ran/0.526
4dltGNPGTPase HRas/0.525
4lhwGNPRas-related protein Rab-8A/0.525
4nyiGNPGTPase HRas/0.525
3oesGNPGTPase RhebL1/0.523
1a2bGSPTransforming protein RhoA/0.522
3rabGNPRas-related protein Rab-3A/0.522
1kmqGNPTransforming protein RhoA/0.521
3i3sGNPGTPase HRas/0.518
3e5hGNPRas-related protein Rab-28/0.516
5b2zGNPGTPase HRas/0.516
3rs5GNPGTPase HRas/0.515
4rkfGNPRas-related protein Rab-3/0.514
3pitGNPRas-related protein M-Ras/0.512
2zetGTPRas-related protein Rab-27B/0.511
1cxzGSPTransforming protein RhoA/0.510
3kucGDPRas-related protein Rap-1A/0.510
2c5lGTPGTPase HRas/0.508
4nyjGNPGTPase HRas/0.508
4hdoGNPRas-related protein Rap-1b/0.506
5hpyGDPTransforming protein RhoA/0.505
1m7bGTPRho-related GTP-binding protein RhoE/0.502
3oiwGNPGTPase HRas/0.502
1k5dGNPGTP-binding nuclear protein Ran/0.499
4dsnGCPGTPase KRas/0.499
1xtrGNPGTP-binding protein Rheb/0.498
2rgeGNPGTPase HRas/0.498
3bbpGTPRas-related protein Rab-6A/0.497
3kkoGNPRas-related protein M-Ras/0.495
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.494
3qbtGNPRas-related protein Rab-8A/0.494
4g0nGNPGTPase HRas/0.494
2rgcGNPGTPase HRas/0.492
3ea5GDPGTP-binding nuclear protein Ran/0.492
4qxaGTPRas-related protein Rab-9A/0.491
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.490
4dlwGNPGTPase HRas/0.489
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.488
2gcpGSPRho-related GTP-binding protein RhoC/0.488
3lawGNPRas-related protein Rab-7a/0.487
1yzqGNPRas-related protein Rab-6A/0.486
3eg5GNPCell division control protein 42 homolog/0.486
1ibrGNPGTP-binding nuclear protein Ran/0.485
1s1cGNPTransforming protein RhoA/0.484
1zd9GDPADP-ribosylation factor-like protein 8A/0.484
4js0GNPCell division control protein 42 homolog/0.483
4uj3GNPRas-related protein Rab-11A/0.483
2rgbGNPGTPase HRas/0.482
3l8yGNPGTPase HRas/0.481
3tsoGNPRas-related protein Rab-25/0.481
3wyfGTPGTP-binding nuclear protein/0.479
5difGNPGTP-binding nuclear protein Ran/0.479
1t91GTPRas-related protein Rab-7a/0.477
4o25GTPGTP-binding protein Rheb/0.477
3cphGDPRas-related protein SEC4/0.476
3lbhGNPGTPase HRas/0.476
1ow3GDPTransforming protein RhoA/0.475
3rs0GNPGTPase HRas/0.475
1zc4GNPRas-related protein Ral-A/0.474
3th5GNPRas-related C3 botulinum toxin substrate 1/0.473
4xoiGTPTransforming protein RhoA/0.473
2fe4GDPRas-related protein Rab-6B/0.472
3tnfGNPRas-related protein Rab-8A/0.470
1oixGDPRas-related protein Rab-11A/0.467
4kvgGTPRas-related protein Rap-1A/0.466
1yhnGTPRas-related protein Rab-7a/0.465
4hdqGNPRas-related protein Rap-1b/0.465
1zc3GNPRas-related protein Ral-A/0.464
3rslGNPGTPase HRas/0.464
3x1zGNPRas-related protein Rap-1b/0.464
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.463
3lbiGNPGTPase HRas/0.463
4dlzGNPGTPase HRas/0.463
1vg8GNPRas-related protein Rab-7a/0.462
1z2cGNPRho-related GTP-binding protein RhoC/0.462
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.461
2bkuGTPGTP-binding nuclear protein Ran/0.460
4uj5GNPRas-related protein Rab-11A/0.460
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.456
3tklGTPRas-related protein Rab-1A/0.456
4cymGCPRas-related protein Rab-32/0.456
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.456
1lfdGNPGTPase HRas/0.454
1uadGNPRas-related protein Ral-A/0.454
2clsGTPRho-related GTP-binding protein Rho6/0.449
3kudGDPGTPase HRas/0.449
3bc1GNPRas-related protein Rab-27A/0.448
4dlsGNPGTPase HRas/0.447
3k8yGNPGTPase HRas/0.446
3rs4GNPGTPase HRas/0.446
4dlxGNPGTPase HRas/0.446
2msdGNPMHC class I alpha chain/0.442
3mjhGTPRas-related protein Rab-5A/0.442
4lucGDPGTPase KRas/0.442
4l9wGNPGTPase HRas/0.440