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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.21.000
4nka2K7Fibroblast growth factor receptor 1/0.527
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.515
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.511
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.510
4id71G0Activated CDC42 kinase 1/0.508
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.504
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.504
2qoqANPEphrin type-A receptor 32.7.10.10.503
4nks2M2Fibroblast growth factor receptor 1/0.502
4jia1K3Tyrosine-protein kinase JAK2/0.501
1pmn984Mitogen-activated protein kinase 102.7.11.240.500
4bbe3O4Tyrosine-protein kinase JAK2/0.500
2hk51BMTyrosine-protein kinase HCK2.7.10.20.499
4anqVGHALK tyrosine kinase receptor2.7.10.10.497
4j95ACPFibroblast growth factor receptor 2/0.497
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.496
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.496
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
2xvdAS6Ephrin type-B receptor 42.7.10.10.492
4gmy0X5Tyrosine-protein kinase JAK2/0.492
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.491
2etm7PYFocal adhesion kinase 12.7.10.20.490
3vs1VSATyrosine-protein kinase HCK2.7.10.20.490
3zewSTUEphrin type-B receptor 42.7.10.10.490
3ttjJBIMitogen-activated protein kinase 102.7.11.240.489
4c4g7RODual specificity protein kinase TTK2.7.12.10.489
4gk4L90Ephrin type-A receptor 32.7.10.10.489
5ap57RODual specificity protein kinase TTK2.7.12.10.489
1bygSTUTyrosine-protein kinase CSK/0.488
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.488
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.487
2c6eHPMAurora kinase A2.7.11.10.486
2izsBRQCasein kinase I isoform gamma-32.7.11.10.484
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.484
4c4f7CEDual specificity protein kinase TTK2.7.12.10.484
2itqITQEpidermal growth factor receptor2.7.10.10.483
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.483
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.482
4ansVGHALK tyrosine kinase receptor2.7.10.10.482
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.481
2xp2VGHALK tyrosine kinase receptor2.7.10.10.481
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.481
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.481
4c4h7RODual specificity protein kinase TTK2.7.12.10.480
3ttiKBIMitogen-activated protein kinase 102.7.11.240.479
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.479
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.477
4qmlANPSerine/threonine-protein kinase 242.7.11.10.477
4ic7ANPMitogen-activated protein kinase 72.7.11.240.476
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.476
3t8oATPRhodopsin kinase/0.475
4b8mVX6Aurora kinase B-A2.7.11.10.475
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.475
4jboWPHAurora kinase A2.7.11.10.475
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.475
3gc9B45Mitogen-activated protein kinase 112.7.11.240.474
3vjoANPEpidermal growth factor receptor2.7.10.10.474
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.474
4hvh19RTyrosine-protein kinase JAK32.7.10.20.474
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.474
2ittAEEEpidermal growth factor receptor2.7.10.10.473
2izrBRKCasein kinase I isoform gamma-32.7.11.10.473
2j0m4STFocal adhesion kinase 12.7.10.20.473
3w2o03PEpidermal growth factor receptor2.7.10.10.473
4c57FEFCyclin-G-associated kinase2.7.11.10.473
4i22IREEpidermal growth factor receptor2.7.10.10.473
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.471
2j0lANPFocal adhesion kinase 12.7.10.20.471
3w2sW2REpidermal growth factor receptor2.7.10.10.471
4j99ACPFibroblast growth factor receptor 2/0.471
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.470
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.470
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
3uvqFS8Mitogen-activated protein kinase 14/0.469
4c58824Cyclin-G-associated kinase2.7.11.10.469
4jbpYPHAurora kinase A2.7.11.10.469
4izy1J2Mitogen-activated protein kinase 82.7.11.240.468
2of2547Tyrosine-protein kinase Lck2.7.10.20.467
2vrx447Aurora kinase B-A2.7.11.10.467
2vwu7X1Ephrin type-B receptor 42.7.10.10.467
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
4j97ACPFibroblast growth factor receptor 2/0.467
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.466
1u54ACPActivated CDC42 kinase 1/0.466
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.466
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.465
2c7xNRBCytochrome P450 monooxygenase PikC/0.465
2qocANPEphrin type-A receptor 32.7.10.10.465
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.465
3gc8B45Mitogen-activated protein kinase 112.7.11.240.465
3igoANPCalmodulin-domain protein kinase 1, putative/0.465
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4c4iX20Dual specificity protein kinase TTK2.7.12.10.465
4fob0USALK tyrosine kinase receptor2.7.10.10.465
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.465
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.465
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2excJNKMitogen-activated protein kinase 102.7.11.240.464
3d7tSTUTyrosine-protein kinase CSK/0.464
4eym0RXMitogen-activated protein kinase 132.7.11.240.464
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4k33ACPFibroblast growth factor receptor 32.7.10.10.464
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2j7t274Serine/threonine-protein kinase 102.7.11.10.463
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.463
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.463
4jbqVX6Aurora kinase A2.7.11.10.463
5aacVGHALK tyrosine kinase receptor2.7.10.10.463
4xlvACPInsulin receptor2.7.10.10.462
2pzpACPFibroblast growth factor receptor 2/0.461
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.461
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.461
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.461
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.460
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.460
3e5aVX6Aurora kinase A2.7.11.10.460
3hx4ANPCalmodulin-domain protein kinase 1/0.460
2yfxVGHALK tyrosine kinase receptor2.7.10.10.459
2zybKSLTyrosine-protein kinase Lck2.7.10.20.459
3l8p0CEAngiopoietin-1 receptor2.7.10.10.459
3zk5Z18Cytochrome P450 monooxygenase PikC/0.459
4cd0AWJALK tyrosine kinase receptor2.7.10.10.459
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.459
2py3ACPFibroblast growth factor receptor 2/0.458
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.458
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.458
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.458
4f640S8Fibroblast growth factor receptor 1/0.458
2of4979Tyrosine-protein kinase Lck2.7.10.20.457
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.457
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.457
4jq8KJ8Epidermal growth factor receptor2.7.10.10.457
4kba1QMCasein kinase I isoform delta2.7.11.10.457
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.457
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.457
2ghmLICMitogen-activated protein kinase 14/0.456
2o0uC0MMitogen-activated protein kinase 102.7.11.240.456
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.456
4gk2L66Ephrin type-A receptor 32.7.10.10.456
4joa3DKALK tyrosine kinase receptor2.7.10.10.456
2v7a627Tyrosine-protein kinase ABL12.7.10.20.455
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.455
4o0wADNAurora kinase A2.7.11.10.455
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.455
5aaaVGHALK tyrosine kinase receptor2.7.10.10.455
1k6cMK1Gag-Pol polyprotein3.4.23.160.454
2henADPEphrin type-B receptor 22.7.10.10.454
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.454
3oroAGSSerine/threonine protein kinase/0.454
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.454
4f630S7Fibroblast growth factor receptor 1/0.454
4riyADPEpidermal growth factor receptor2.7.10.10.454
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.454
2x9fX9FEphrin type-B receptor 42.7.10.10.453
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.453
3h0aD30Peroxisome proliferator-activated receptor gamma/0.453
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.453
3nwq2NCGag-Pol polyprotein3.4.23.160.453
3oom507Activin receptor type-12.7.11.300.453
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.453
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
1sn5T3Transthyretin/0.452
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4jrvKJVEpidermal growth factor receptor2.7.10.10.452
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.452
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.452
4xhgADPUncharacterized protein/0.452
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.451
2ijmATPFocal adhesion kinase 12.7.10.20.451
3mpaSB2Mitogen-activated protein kinase 14/0.451
4grb0XGCasein kinase II subunit alpha2.7.11.10.451
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.451
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.451
1wvxBD4Death-associated protein kinase 12.7.11.10.450
2b1pAIZMitogen-activated protein kinase 102.7.11.240.450
2pz5ACPFibroblast growth factor receptor 2/0.450
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.450
4l9q9TPSerum albumin/0.450
4wkqIREEpidermal growth factor receptor2.7.10.10.450
2itzIREEpidermal growth factor receptor2.7.10.10.449
2j0dERYCytochrome P450 3A4/0.449
2j0k4STFocal adhesion kinase 12.7.10.20.449
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.449
3nwyGTPUridylate kinase/0.449
4c3pACPAurora kinase A2.7.11.10.449
4nb6444Nuclear receptor ROR-gamma/0.449
2vwy7X5Ephrin type-B receptor 42.7.10.10.448
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.448
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.448
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.448
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.448
4hgt15GCasein kinase I isoform delta2.7.11.10.448
5auwQUEDeath-associated protein kinase 12.7.11.10.448
1ie4T44Transthyretin/0.447
1w84L12Mitogen-activated protein kinase 14/0.447
2ijmADPFocal adhesion kinase 12.7.10.20.447
2o2u738Mitogen-activated protein kinase 102.7.11.240.447
2vww7X2Ephrin type-B receptor 42.7.10.10.447
2y03Y01Beta-1 adrenergic receptor/0.447
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.447
4gk3L87Ephrin type-A receptor 32.7.10.10.447
4z34ON7Lysophosphatidic acid receptor 1/0.447
1k6pXN3Gag-Pol polyprotein3.4.23.160.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.446
2c6hPXICytochrome P450 monooxygenase PikC/0.446
2hog710Serine/threonine-protein kinase Chk12.7.11.10.446
2hw2RFPRifampin ADP-ribosyl transferase/0.446
2itnANPEpidermal growth factor receptor2.7.10.10.446
2vwz7X6Ephrin type-B receptor 42.7.10.10.446
2vx17X8Ephrin type-B receptor 42.7.10.10.446
2vzmNRBCytochrome P450 monooxygenase PikC/0.446
3c4xATPRhodopsin kinase/0.446
3icrCOACoenzyme A disulfide reductase/0.446
3kf7L9GMitogen-activated protein kinase 14/0.446
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.446
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.446
4g170VNCasein kinase I isoform gamma-32.7.11.10.446
5e8wSTUTGF-beta receptor type-12.7.11.300.446
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.445
1xjdSTUProtein kinase C theta type2.7.11.130.445
1zrzBI1Protein kinase C iota type2.7.11.130.445
2ca0PXICytochrome P450 monooxygenase PikC/0.445
2ckeIQUDeath-associated protein kinase 2/0.445
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.445
2w1fL0FAurora kinase A2.7.11.10.445
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.445
3a7hATPSerine/threonine-protein kinase 242.7.11.10.445
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.445
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3t2zFADSulfide-quinone reductase/0.445
4b7sQLECytochrome P450 monooxygenase PikC/0.445
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.445
2aidTHKGag-Pol polyprotein3.4.23.160.444
2hw1ANPKetohexokinase/0.444
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.444
3fpbCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
3gubGUBDeath-associated protein kinase 12.7.11.10.444
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.444
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.444
4c59FEFCyclin-G-associated kinase2.7.11.10.444
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4o0uADNAurora kinase A2.7.11.10.444
4q72FADBifunctional protein PutA/0.444
4wboANWRhodopsin kinase/0.444
1yvj4STTyrosine-protein kinase JAK32.7.10.20.443
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.443
2qo9ANPEphrin type-A receptor 32.7.10.10.443
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.443
3js2VM1Fibroblast growth factor receptor 1/0.443
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.443
3mtfA3FActivin receptor type-12.7.11.300.443
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.443
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.443
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.443
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
2qa1FADPgaE/0.442
2y6o1N1Ephrin type-A receptor 42.7.10.10.442
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.442
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.442
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.442
4fv9E71Mitogen-activated protein kinase 12.7.11.240.442
4fyn0VETyrosine-protein kinase SYK2.7.10.20.442
4kb81QNCasein kinase I isoform delta2.7.11.10.442
4l9i8PRRhodopsin kinase/0.442
1ee0CAA2-pyrone synthase/0.441
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.441
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.441
2p33J07Mitogen-activated protein kinase 102.7.11.240.441
2q0bACPFibroblast growth factor receptor 2/0.441
2vd5BI8Myotonin-protein kinase2.7.11.10.441
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.441
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.441
3kpkFADSulfide-quinone reductase/0.441
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3mdvCL6Cholesterol 24-hydroxylase/0.441
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.441
4jrnANPRhoptry kinase family protein/0.441
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.441
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.440
1xl2189Gag-Pol polyprotein3.4.23.160.440
2pwlACPFibroblast growth factor receptor 2/0.440
2yn8STUEphrin type-B receptor 42.7.10.10.440
3gggNADPrephenate dehydrogenase/0.440
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3uo50BXAurora kinase A2.7.11.10.440
3vs3VSETyrosine-protein kinase HCK2.7.10.20.440
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.440
4b7dQLECytochrome P450 monooxygenase PikC/0.440
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.440
4ia7BIVVitamin D3 receptor A/0.440
4ysjADPCalmodulin-like domain protein kinase/0.440