scPDB - Distribution of Binding site Similarity values of 4mcc entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4mcc	21X	tRNA (guanine-N(1)-)-methyltransferase	2.1.1.228

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4mcc	21X	tRNA (guanine-N(1)-)-methyltransferase	2.1.1.228	1.000
4mcb	21W	tRNA (guanine-N(1)-)-methyltransferase	2.1.1.228	0.793
3zew	STU	Ephrin type-B receptor 4	2.7.10.1	0.485
4h3z	SAH	tRNA (guanine-N(1)-)-methyltransferase	/	0.485
2cx8	SAH	Ribosomal RNA small subunit methyltransferase E	/	0.478
4cki	ADN	Proto-oncogene tyrosine-protein kinase receptor Ret	2.7.10.1	0.476
4o0s	ADN	Aurora kinase A	2.7.11.1	0.473
1bws	NDP	GDP-L-fucose synthase	/	0.470
3cd3	STU	Tyrosine-protein kinase Fes/Fps	2.7.10.2	0.469
5ack	ATP	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.469
3bkb	STU	Tyrosine-protein kinase Fes/Fps	2.7.10.2	0.467
4mcd	22L	tRNA (guanine-N(1)-)-methyltransferase	2.1.1.228	0.464
1xl2	189	Gag-Pol polyprotein	3.4.23.16	0.462
5dr9	SKE	Aurora kinase A	2.7.11.1	0.462
1rfv	ADP	Pyridoxal kinase	2.7.1.35	0.461
3cbl	STU	Tyrosine-protein kinase Fes/Fps	2.7.10.2	0.461
3hrf	ATP	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.459
1noo	CAH	Camphor 5-monooxygenase	1.14.15.1	0.456
3ckx	STU	Serine/threonine-protein kinase 24	2.7.11.1	0.456
1k6t	XN1	Gag-Pol polyprotein	3.4.23.16	0.455
4jaj	XU1	Aurora kinase A	2.7.11.1	0.455
3cjg	KIM	Vascular endothelial growth factor receptor 2	2.7.10.1	0.454
2dq7	STU	Tyrosine-protein kinase Fyn	2.7.10.2	0.453
4bf2	STU	Mitogen-activated protein kinase kinase kinase 5	2.7.11.25	0.452
1rkx	NAD	CDP-D-glucose-4,6-dehydratase	/	0.451
1zrz	BI1	Protein kinase C iota type	2.7.11.13	0.451
4ct1	ATP	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.451
4gk3	L87	Ephrin type-A receptor 3	2.7.10.1	0.451
1bsv	NDP	GDP-L-fucose synthase	/	0.450
1nzd	UPG	DNA beta-glucosyltransferase	/	0.450
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.450
4yzc	STU	Serine/threonine-protein kinase/endoribonuclease IRE1	2.7.11.1	0.450
3awi	FAD	tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC	1.5	0.449
4nk9	2K5	Fibroblast growth factor receptor 1	/	0.449
4yao	FMN	NADPH--cytochrome P450 reductase	/	0.449
2clq	STU	Mitogen-activated protein kinase kinase kinase 5	2.7.11.25	0.448
2x0i	NAI	Malate dehydrogenase	/	0.448
3ajr	NAD	NDP-sugar epimerase	/	0.448
3bc3	OPT	Cathepsin L1	3.4.22.15	0.448
3v1y	NAD	Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic	1.2.1.12	0.448
2yn8	STU	Ephrin type-B receptor 4	2.7.10.1	0.447
4rqk	ATP	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.447
1u54	ACP	Activated CDC42 kinase 1	/	0.446
2v7a	627	Tyrosine-protein kinase ABL1	2.7.10.2	0.446
3t11	3T1	Gag-Pol polyprotein	3.4.23.16	0.446
3wmx	NAD	NAD dependent epimerase/dehydratase	/	0.446
4ewh	T77	Activated CDC42 kinase 1	/	0.446
4fr4	STU	Serine/threonine-protein kinase 32A	2.7.11.1	0.446
4ft7	H3K	Serine/threonine-protein kinase Chk1	2.7.11.1	0.446
4y93	746	Tyrosine-protein kinase	/	0.446
5a4k	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.446
5dr6	SKE	Aurora kinase A	2.7.11.1	0.446
1fxs	NAP	GDP-L-fucose synthase	/	0.445
2cgw	3C3	Serine/threonine-protein kinase Chk1	2.7.11.1	0.445
4c02	TAK	Activin receptor type-1	2.7.11.30	0.445
4c34	STU	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.445
4hvg	19Q	Tyrosine-protein kinase JAK3	2.7.10.2	0.445
4ly9	1YY	Glucokinase regulatory protein	/	0.445
4xgu	ADP	Putative pachytene checkpoint protein 2	/	0.445
2csn	CKI	Casein kinase I homolog 1	2.7.11.1	0.444
2gcg	NDP	Glyoxylate reductase/hydroxypyruvate reductase	1.1.1.79	0.444
2pzi	AXX	Serine/threonine-protein kinase PknG	2.7.11.1	0.444
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.444
3hdm	MMG	Serine/threonine-protein kinase Sgk1	2.7.11.1	0.444
3i60	E86	Mitogen-activated protein kinase 1	2.7.11.24	0.444
4ks8	B49	Serine/threonine-protein kinase PAK 6	2.7.11.1	0.444
4u7w	NDP	MxaA	/	0.444
1eh4	IC1	Casein kinase I homolog 1	2.7.11.1	0.443
1m2r	MNY	Casein kinase II subunit alpha	2.7.11.1	0.443
1p9p	SAH	tRNA (guanine-N(1)-)-methyltransferase	/	0.443
2gcd	STU	Serine/threonine-protein kinase TAO2	2.7.11.1	0.443
3hll	I45	Mitogen-activated protein kinase 14	/	0.443
3hwr	NDP	2-dehydropantoate 2-reductase	/	0.443
3nwx	KVS	Gag-Pol polyprotein	3.4.23.16	0.443
3pxk	PXK	Focal adhesion kinase 1	2.7.10.2	0.443
1e3e	NAI	Alcohol dehydrogenase 4	1.1.1.1	0.442
1kbo	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.442
1okz	UCN	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.442
2ibz	UQ6	Cytochrome b	/	0.442
4g7g	VFV	Lanosterol 14-alpha-demethylase	/	0.442
4h3y	SAH	tRNA (guanine-N(1)-)-methyltransferase	/	0.442
1dxq	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.441
1k6c	MK1	Gag-Pol polyprotein	3.4.23.16	0.441
4c61	LMM	Tyrosine-protein kinase JAK2	/	0.441
4dym	IYZ	Activin receptor type-1	2.7.11.30	0.441
4r20	AER	Cytochrome P450 family 17 polypeptide 2	/	0.441
4tuv	CPZ	Cytochrome P450 119	1.14	0.441
5dpv	SKE	Aurora kinase A	2.7.11.1	0.441
1g4t	FTP	Thiamine-phosphate synthase	/	0.440
2brg	DFY	Serine/threonine-protein kinase Chk1	2.7.11.1	0.440
2bro	DF2	Serine/threonine-protein kinase Chk1	2.7.11.1	0.440
3cyl	VIT	Basic phospholipase A2 homolog piratoxin-2	/	0.440
3inx	JZC	Heat shock protein HSP 90-alpha	/	0.440
4e4m	0NH	Tyrosine-protein kinase JAK2	/	0.440
4xum	IMN	Peroxisome proliferator-activated receptor gamma	/	0.440