scPDB - Distribution of Binding site Similarity values of 4m6l entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4m6l	21V	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4m6l	21V	Dihydrofolate reductase	1.5.1.3	1.000
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.655
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.620
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.605
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.578
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.571
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.567
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.565
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.561
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.559
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.556
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.552
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.549
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.548
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.546
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.537
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.535
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.531
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.524
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.522
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.519
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.515
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.513
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.512
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.511
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.510
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.508
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.500
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.494
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.491
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.489
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.486
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.485
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.485
3qly	55V	Uncharacterized protein	/	0.483
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.483
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.481
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.477
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.475
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.474
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.473
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.471
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.469
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.465
2zza	FOL	Dihydrofolate reductase	/	0.464
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.464
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.461
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.460
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
3qlz	QLZ	Uncharacterized protein	/	0.457
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.456
3cse	N22	Uncharacterized protein	/	0.455
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.454
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.454
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.453
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.451
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.449
3eek	53S	Uncharacterized protein	/	0.449
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.449
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.449
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.448
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.447
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.445
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.445
3qlx	QLR	Uncharacterized protein	/	0.445
2zsd	COA	Pantothenate kinase	2.7.1.33	0.441
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.441
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.441
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.441
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.440