scPDB - Distribution of Binding site Similarity values of 4m6k entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4m6k	FOL	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	1.000
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.643
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.624
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.605
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.603
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.595
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.586
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.567
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.567
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.557
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.553
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.551
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.546
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.543
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.541
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.535
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.532
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.529
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.524
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.524
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.516
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.507
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.503
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.501
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.500
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.499
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.495
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.493
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.492
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.488
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.482
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.481
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.481
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.473
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.470
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.467
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.464
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.463
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.451
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.450
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.443