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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4m6jNDPDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4m6jNDPDihydrofolate reductase1.5.1.31.000
3qlrNDPDihydrofolate reductase1.5.1.30.624
1ia1NDPDihydrofolate reductase1.5.1.30.615
1m78NDPDihydrofolate reductase1.5.1.30.598
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.597
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.589
1ai9NDPDihydrofolate reductase1.5.1.30.588
3qlsNDPDihydrofolate reductase1.5.1.30.584
1dr2TAPDihydrofolate reductase1.5.1.30.583
1drhNAPDihydrofolate reductase1.5.1.30.573
1dr3TAPDihydrofolate reductase1.5.1.30.570
1rx1NAPDihydrofolate reductase1.5.1.30.570
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.570
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.570
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.560
1dr5NAPDihydrofolate reductase1.5.1.30.556
1dg8NDPDihydrofolate reductase1.5.1.30.551
3d84NDPDihydrofolate reductase1.5.1.30.543
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.541
3tqaNDPDihydrofolate reductase/0.530
2cig1DGDihydrofolate reductase1.5.1.30.525
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.525
5eccNAPDehydrofolate reductase type I/0.520
1ia4TQ6Dihydrofolate reductase1.5.1.30.519
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.519
8dfrNDPDihydrofolate reductase1.5.1.30.512
3nxxNDPDihydrofolate reductase1.5.1.30.509
4gl4NAIAlcohol dehydrogenase class-3/0.497
4kl9NDPDihydrofolate reductase1.5.1.30.491
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.484
4g3jVNTLanosterol 14-alpha-demethylase/0.483
4a83DXCMajor pollen allergen Bet v 1-A/0.476
1ia3TQ5Dihydrofolate reductase1.5.1.30.475
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.475
3tjzGNPADP-ribosylation factor 1/0.474
4bb3KKAIsopenicillin N synthase1.21.3.10.474
3gqvNAPEnoyl reductase LovC10.473
2w9hTOPDihydrofolate reductase1.5.1.30.472
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.471
1tehNADAlcohol dehydrogenase class-31.1.1.10.471
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.471
2iko7IGRenin3.4.23.150.470
3a3gDLZLumazine protein/0.470
3fpzAHZThiamine thiazole synthase/0.470
4ambDUDPutative glycosyl transferase/0.470
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.470
1w6hTITPlasmepsin-23.4.23.390.469
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.469
1xddAAYIntegrin alpha-L/0.468
2a94AP0L-lactate dehydrogenase1.1.1.270.468
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.468
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.468
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.468
1me6IVSPlasmepsin-23.4.23.390.466
2il2LIXRenin3.4.23.150.466
3vdqNAD3-hydroxybutyrate dehydrogenase/0.465
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.465
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.463
4q71FADBifunctional protein PutA/0.462
1geeNADGlucose 1-dehydrogenase1.1.1.470.461
3b6zCO7Enoyl reductase LovC10.461
4l0qNADAlcohol dehydrogenase class-3/0.461
1t2cNAIL-lactate dehydrogenase1.1.1.270.460
2geuCOKPantothenate kinase2.7.1.330.460
3f03FMNPentaerythritol tetranitrate reductase/0.460
4a81DXCMajor pollen allergen Bet v 1-A/0.460
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.460
4m83ERYOleandomycin glycosyltransferase2.4.10.460
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.460
5eioNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.460
3lqfNADGalactitol dehydrogenase/0.459
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.459
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
4rww2BALmo2692 protein/0.459
1u71MXADihydrofolate reductase1.5.1.30.458
2aa3AP0L-lactate dehydrogenase/0.458
2g1r3IGRenin3.4.23.150.458
2g8yNADHydroxycarboxylate dehydrogenase B/0.458
3il1B5DGlutamate receptor 2/0.458
1g1aNADdTDP-glucose 4,6-dehydratase/0.457
1rfuADPPyridoxal kinase2.7.1.350.457
2g247IGRenin3.4.23.150.457
2vwqNAPGlucose 1-dehydrogenase/0.457
4ejmNAPPutative zinc-binding dehydrogenase/0.457
1xe55FEPlasmepsin-23.4.23.390.456
2a92NAIL-lactate dehydrogenase/0.456
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2dhfDZFDihydrofolate reductase1.5.1.30.456
2ft9CHDFatty acid-binding protein 2, liver/0.456
2g1n1IGRenin3.4.23.150.456
2iyaZIOOleandomycin glycosyltransferase/0.456
3bc3OPTCathepsin L13.4.22.150.456
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.456
3oafOAGDihydrofolate reductase1.5.1.30.456
3toxNAPPutative oxidoreductase/0.456
4xq9NADHomospermidine synthase2.5.1.440.456
1mjbACOHistone acetyltransferase ESA1/0.455
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.455
4bfxZVXPantothenate kinase2.7.1.330.455
4q73FADBifunctional protein PutA/0.455
2iyfERYOleandomycin glycosyltransferase2.4.10.454
3phiNDPShikimate dehydrogenase (NADP(+))/0.454
4ef9FMNDihydroorotate dehydrogenase (fumarate)/0.454
1gcoNADGlucose 1-dehydrogenase1.1.1.470.453
2d29FADAcyl-CoA dehydrogenase/0.453
2hm1LIQBeta-secretase 13.4.23.460.453
3ai3NDPNADPH-sorbose reductase/0.453
3gw9VNILanosterol 14-alpha-demethylase/0.453
3h2sNDPPutative NADH-flavin reductase/0.453
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.453
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.452
2rqfJH3Hemolymph juvenile hormone binding protein/0.452
3a4vNADNDP-sugar epimerase/0.452
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.452
5d3qGDPDynamin-13.6.5.50.452
1bim0QBRenin3.4.23.150.451
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.451
1zemNADXylitol dehydrogenase/0.451
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.451
2q46NAPUncharacterized protein At5g02240/0.451
3drcMTXDihydrofolate reductase1.5.1.30.451
3hx4ANPCalmodulin-domain protein kinase 1/0.451
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.451
1fm4DXCMajor pollen allergen Bet v 1-L/0.450
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.450
3ig6438Urokinase-type plasminogen activator3.4.21.730.450
3r83Z14Cyclin-dependent kinase 22.7.11.220.450
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
1g6kNADGlucose 1-dehydrogenase1.1.1.470.449
1tqf32PBeta-secretase 13.4.23.460.449
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.449
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.449
2ifaFMNUncharacterized protein/0.449
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.449
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4ew2DXYTrifunctional purine biosynthetic protein adenosine-32.1.2.20.449
4ke11R6Beta-secretase 13.4.23.460.449
4nbwNADShort-chain dehydrogenase/reductase SDR/0.449
5a3bAPRSIR2 family protein/0.449
1hdoNAPFlavin reductase (NADPH)/0.448
2gv8NDPThiol-specific monooxygenase1.14.130.448
2rcyNAPPyrroline-5-carboxylate reductase/0.448
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.448
4ew3DXZTrifunctional purine biosynthetic protein adenosine-32.1.2.20.448
4klaCHDFerrochelatase, mitochondrial4.99.1.10.448
1e3eNAIAlcohol dehydrogenase 41.1.1.10.447
1f8fNADBenzyl alcohol dehydrogenase/0.447
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.447
2c29NAPDihydroflavonol 4-reductase/0.447
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.447
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.447
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.447
3a1nNADNDP-sugar epimerase/0.447
3ieuGDPGTPase Era/0.447
4a6bQG8Gag-Pol polyprotein3.4.23.160.447
4irnFADAnaB/0.447
4xguADPPutative pachytene checkpoint protein 2/0.447
1lf3EH5Plasmepsin-23.4.23.390.446
1xe65FPPlasmepsin-23.4.23.390.446
2y0mACOHistone acetyltransferase KAT8/0.446
4bfzZVZPantothenate kinase2.7.1.330.446
4i8zG08Gag-Pol polyprotein3.4.23.160.446
4q72FADBifunctional protein PutA/0.446
4xqcNADHomospermidine synthase2.5.1.440.446
2qo9ANPEphrin type-A receptor 32.7.10.10.445
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.445
3gobHXXDdmC/0.445
3uylTYDProbable NDP-rhamnosyltransferase/0.445
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4bfsZVSPantothenate kinase2.7.1.330.445
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.445
4f6w0SSCyclin-dependent kinase 82.7.11.220.445
1cf3FADGlucose oxidase1.1.3.40.444
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.444
2b58COADiamine acetyltransferase 1/0.444
2e15SAHDiphthine synthase/0.444
2rlcCHDCholoylglycine hydrolase3.5.1.240.444
3mdmFJZCholesterol 24-hydroxylase/0.444
3r7kFDAProbable acyl CoA dehydrogenase/0.444
3to6LYS_CMCHistone acetyltransferase ESA1/0.444
4djaFAD(6-4) photolyase/0.444
1c1dNAIPhenylalanine dehydrogenase/0.443
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.443
1fy7COAHistone acetyltransferase ESA1/0.443
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
2givACOHistone acetyltransferase KAT8/0.443
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.443
3c1y2BADNA integrity scanning protein DisA/0.443
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.443
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.443
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.442
1rwbNADGlucose 1-dehydrogenase1.1.1.470.442
2ejvNADL-threonine 3-dehydrogenase/0.442
2irzI02Beta-secretase 13.4.23.460.442
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3bk2U5PRibonuclease J/0.442
3clrFADElectron transfer flavoprotein subunit alpha/0.442
3e2sFADBifunctional protein PutA1.5.5.20.442
3vydVYDRenin3.4.23.150.442
3zuyTCHTransporter/0.442
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.442
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.442
4uymVOR14-alpha sterol demethylase Cyp51B/0.442
1nboNADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.441
1rneC60Renin3.4.23.150.441
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.441
2c20NADUDP-glucose 4-epimerase/0.441
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.441
2dvlFADAcyl-CoA dehydrogenase/0.441
2ebaFADPutative glutaryl-CoA dehydrogenase/0.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.441
3in6FMNUncharacterized protein/0.441
3r9uFADThioredoxin reductase/0.441
3t1tGDPProbable gliding protein mglA/0.441
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.441
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.441
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.441
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.440
1lbcCYZGlutamate receptor 2/0.440
1ur5NADMalate dehydrogenase/0.440
1y9dTPPPyruvate oxidase1.2.3.30.440
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.440
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.440
2zbaZBATrichothecene 3-O-acetyltransferase/0.440
3fp0FP015-O-acetyltransferase/0.440
3h06VBPGlutamate receptor 2/0.440
3hl0NADMaleylacetate reductase/0.440
3isjA8DPantothenate synthetase6.3.2.10.440
3zeiAWHO-acetylserine sulfhydrylase/0.440
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.440
4dd8BATDisintegrin and metalloproteinase domain-containing protein 83.4.240.440
4emtC2EStimulator of interferon genes protein/0.440
5jlaNADPutative short-chain dehydrogenase/reductase/0.440