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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.11.000
5cnoANPEpidermal growth factor receptor2.7.10.10.472
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.471
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.469
5cnnANPEpidermal growth factor receptor2.7.10.10.463
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.462
1b38ATPCyclin-dependent kinase 22.7.11.220.461
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.459
4qnyANPMitogen activated protein kinase, putative/0.455
3mtfA3FActivin receptor type-12.7.11.300.452
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.448
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
5e8ySTUTGF-beta receptor type-22.7.11.300.445
1qmzATPCyclin-dependent kinase 22.7.11.220.444
1bygSTUTyrosine-protein kinase CSK/0.443
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.443
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.441