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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4lyn1YGCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4lyn1YGCyclin-dependent kinase 22.7.11.221.000
2r64740Cyclin-dependent kinase 22.7.11.220.626
3qwjX6ACyclin-dependent kinase 22.7.11.220.625
3lfnA27Cyclin-dependent kinase 22.7.11.220.620
3lfsA07Cyclin-dependent kinase 22.7.11.220.619
4fki09KCyclin-dependent kinase 22.7.11.220.615
2duv371Cyclin-dependent kinase 22.7.11.220.613
3roy22ZCyclin-dependent kinase 22.7.11.220.603
3qu0X40Cyclin-dependent kinase 22.7.11.220.602
2a0cCK9Cyclin-dependent kinase 22.7.11.220.593
3rk909ZCyclin-dependent kinase 22.7.11.220.593
2xmyCDKCyclin-dependent kinase 22.7.11.220.588
3rpo24ZCyclin-dependent kinase 22.7.11.220.585
1ke6LS2Cyclin-dependent kinase 22.7.11.220.579
3r7yZ04Cyclin-dependent kinase 22.7.11.220.579
3rk708ZCyclin-dependent kinase 22.7.11.220.579
1v1k3FPCyclin-dependent kinase 22.7.11.220.577
3r6xX84Cyclin-dependent kinase 22.7.11.220.577
1w0xOLOCyclin-dependent kinase 22.7.11.220.576
3lfqA28Cyclin-dependent kinase 22.7.11.220.574
1h1r6CPCyclin-dependent kinase 22.7.11.220.573
2a4lRRCCyclin-dependent kinase 22.7.11.220.573
3qx2X63Cyclin-dependent kinase 22.7.11.220.571
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.570
3qxoX65Cyclin-dependent kinase 22.7.11.220.570
3rm719ZCyclin-dependent kinase 22.7.11.220.569
1pxmCK5Cyclin-dependent kinase 22.7.11.220.568
1w8cN69Cyclin-dependent kinase 22.7.11.220.566
3r73X87Cyclin-dependent kinase 22.7.11.220.565
3s2pPMUCyclin-dependent kinase 22.7.11.220.564
3r1yX76Cyclin-dependent kinase 22.7.11.220.563
1ke7LS3Cyclin-dependent kinase 22.7.11.220.562
3rpv26ZCyclin-dependent kinase 22.7.11.220.562
4fkq42KCyclin-dependent kinase 22.7.11.220.562
3iggEFQCyclin-dependent kinase 22.7.11.220.561
2b52D42Cyclin-dependent kinase 22.7.11.220.560
3ezvEZVCyclin-dependent kinase 22.7.11.220.560
3ddqRRCCyclin-dependent kinase 22.7.11.220.558
3r1qX75Cyclin-dependent kinase 22.7.11.220.558
3rm618ZCyclin-dependent kinase 22.7.11.220.558
1g5sI17Cyclin-dependent kinase 22.7.11.220.557
3sqq99ZCyclin-dependent kinase 22.7.11.220.556
2r3kSCQCyclin-dependent kinase 22.7.11.220.555
3ezrEZRCyclin-dependent kinase 22.7.11.220.554
1oguST8Cyclin-dependent kinase 22.7.11.220.553
1pxoCK7Cyclin-dependent kinase 22.7.11.220.553
3qqfX07Cyclin-dependent kinase 22.7.11.220.553
2w05FRTCyclin-dependent kinase 22.7.11.220.552
3ddpRC8Cyclin-dependent kinase 22.7.11.220.552
3qzgX67Cyclin-dependent kinase 22.7.11.220.552
3r1sX73Cyclin-dependent kinase 22.7.11.220.552
4acm7YGCyclin-dependent kinase 22.7.11.220.552
3qzhX69Cyclin-dependent kinase 22.7.11.220.551
2c6o4SPCyclin-dependent kinase 22.7.11.220.549
1ykr628Cyclin-dependent kinase 22.7.11.220.547
1gih1PUCyclin-dependent kinase 22.7.11.220.545
1oitHDTCyclin-dependent kinase 22.7.11.220.544
3r7uX96Cyclin-dependent kinase 22.7.11.220.543
4ek816KCyclin-dependent kinase 22.7.11.220.542
1gii1PUCyclin-dependent kinase 22.7.11.220.541
2w06FRVCyclin-dependent kinase 22.7.11.220.540
2uzoC62Cyclin-dependent kinase 22.7.11.220.538
3qtuX44Cyclin-dependent kinase 22.7.11.220.538
2btsU32Cyclin-dependent kinase 22.7.11.220.536
3qruX19Cyclin-dependent kinase 22.7.11.220.536
3r71X86Cyclin-dependent kinase 22.7.11.220.535
3r83Z14Cyclin-dependent kinase 22.7.11.220.535
2r3lSCWCyclin-dependent kinase 22.7.11.220.534
2vv9IM9Cyclin-dependent kinase 22.7.11.220.534
1di8DTQCyclin-dependent kinase 22.7.11.220.533
1p2a5BNCyclin-dependent kinase 22.7.11.220.533
2iw94SPCyclin-dependent kinase 22.7.11.220.533
2r3mSCXCyclin-dependent kinase 22.7.11.220.533
4fkv61KCyclin-dependent kinase 22.7.11.220.533
1ke5LS1Cyclin-dependent kinase 22.7.11.220.532
2b55D31Cyclin-dependent kinase 22.7.11.220.532
3qqkX02Cyclin-dependent kinase 22.7.11.220.532
3r28XA0Cyclin-dependent kinase 22.7.11.220.532
1ckpPVBCyclin-dependent kinase 22.7.11.220.531
3r9dX6BCyclin-dependent kinase 22.7.11.220.531
1vyw292Cyclin-dependent kinase 22.7.11.220.530
3le62BZCyclin-dependent kinase 22.7.11.220.530
3rkb12ZCyclin-dependent kinase 22.7.11.220.530
3s1h56ZCyclin-dependent kinase 22.7.11.220.530
1oiqHDUCyclin-dependent kinase 22.7.11.220.529
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.529
3rjc06ZCyclin-dependent kinase 22.7.11.220.529
3rni21ZCyclin-dependent kinase 22.7.11.220.529
1oi9N20Cyclin-dependent kinase 22.7.11.220.528
3r8lZ30Cyclin-dependent kinase 22.7.11.220.528
3rk507ZCyclin-dependent kinase 22.7.11.220.528
1pxlCK4Cyclin-dependent kinase 22.7.11.220.527
1e9hINRCyclin-dependent kinase 22.7.11.220.526
2vtsLZCCyclin-dependent kinase 22.7.11.220.525
4erwSTUCyclin-dependent kinase 22.7.11.220.524
4fkpLS5Cyclin-dependent kinase 22.7.11.220.524
3qtxX43Cyclin-dependent kinase 22.7.11.220.523
4bcoT6QCyclin-dependent kinase 22.7.11.220.523
4bcmT7ZCyclin-dependent kinase 22.7.11.220.522
4eon1ROCyclin-dependent kinase 22.7.11.220.522
1h0w207Cyclin-dependent kinase 22.7.11.220.521
2w1hL0FCyclin-dependent kinase 22.7.11.220.521
3r8vZ62Cyclin-dependent kinase 22.7.11.220.521
3rak03ZCyclin-dependent kinase 22.7.11.220.521
3ti1B49Cyclin-dependent kinase 22.7.11.220.521
1hckATPCyclin-dependent kinase 22.7.11.220.519
2btrU73Cyclin-dependent kinase 22.7.11.220.519
3qtzX42Cyclin-dependent kinase 22.7.11.220.519
3qwkX62Cyclin-dependent kinase 22.7.11.220.519
3sw418KCyclin-dependent kinase 22.7.11.220.519
4bgh3I6Cyclin-dependent kinase 22.7.11.220.518
4fkj11KCyclin-dependent kinase 22.7.11.220.518
4fks46KCyclin-dependent kinase 22.7.11.220.518
2wpa889Cyclin-dependent kinase 22.7.11.220.517
1oiuN76Cyclin-dependent kinase 22.7.11.220.516
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.516
2vu3LZECyclin-dependent kinase 22.7.11.220.515
3ral04ZCyclin-dependent kinase 22.7.11.220.515
1h1s4SPCyclin-dependent kinase 22.7.11.220.514
3ig7EFPCyclin-dependent kinase 22.7.11.220.514
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.513
3r7iX9ICyclin-dependent kinase 22.7.11.220.513
3sw719KCyclin-dependent kinase 22.7.11.220.513
2fvdLIACyclin-dependent kinase 22.7.11.220.512
4bcpT3CCyclin-dependent kinase 22.7.11.220.512
1y91CT9Cyclin-dependent kinase 22.7.11.220.511
2r3jSCJCyclin-dependent kinase 22.7.11.220.511
3qtrX36Cyclin-dependent kinase 22.7.11.220.511
3qxpX64Cyclin-dependent kinase 22.7.11.220.511
1oiyN41Cyclin-dependent kinase 22.7.11.220.510
1r78FMDCyclin-dependent kinase 22.7.11.220.510
2c6tDT5Cyclin-dependent kinase 22.7.11.220.510
3r7eX88Cyclin-dependent kinase 22.7.11.220.510
3rahO1ZCyclin-dependent kinase 22.7.11.220.510
3rmf20ZCyclin-dependent kinase 22.7.11.220.510
3unk0BYCyclin-dependent kinase 22.7.11.220.510
4eok4SPCyclin-dependent kinase 22.7.11.220.510
2c5yMTWCyclin-dependent kinase 22.7.11.220.509
3r7vZ02Cyclin-dependent kinase 22.7.11.220.509
3s0o50ZCyclin-dependent kinase 22.7.11.220.509
4ek610KCyclin-dependent kinase 22.7.11.220.509
1fvt106Cyclin-dependent kinase 22.7.11.220.508
3qqhX0ACyclin-dependent kinase 22.7.11.220.507
1e1xNW1Cyclin-dependent kinase 22.7.11.220.506
2r3p3SCCyclin-dependent kinase 22.7.11.220.506
4cfnJYMCyclin-dependent kinase 22.7.11.220.506
4fkr45KCyclin-dependent kinase 22.7.11.220.506
1h1q2A6Cyclin-dependent kinase 22.7.11.220.505
1pxpCK8Cyclin-dependent kinase 22.7.11.220.504
2iw84SPCyclin-dependent kinase 22.7.11.220.504
4ez30S0Cyclin-dependent kinase 22.7.11.220.504
1pxkCK3Cyclin-dependent kinase 22.7.11.220.503
2uznC96Cyclin-dependent kinase 22.7.11.220.503
3tiz3TICyclin-dependent kinase 22.7.11.220.503
4eor4SPCyclin-dependent kinase 22.7.11.220.502
1ke8LS4Cyclin-dependent kinase 22.7.11.220.501
2j9mPY8Cyclin-dependent kinase 22.7.11.220.501
2b54D05Cyclin-dependent kinase 22.7.11.220.500
1pyePM1Cyclin-dependent kinase 22.7.11.220.499
1unlRRCCyclin-dependent-like kinase 52.7.11.10.499
3raiX85Cyclin-dependent kinase 22.7.11.220.499
3fz1B98Cyclin-dependent kinase 22.7.11.220.497
2r3iSCFCyclin-dependent kinase 22.7.11.220.496
3qx4X4BCyclin-dependent kinase 22.7.11.220.495
2vthLZ2Cyclin-dependent kinase 22.7.11.220.494
1urwI1PCyclin-dependent kinase 22.7.11.220.493
4fx360KCyclin-dependent kinase 22.7.11.220.493
3pj8404Cyclin-dependent kinase 22.7.11.220.492
2vtqLZACyclin-dependent kinase 22.7.11.220.491
4fkt48KCyclin-dependent kinase 22.7.11.220.491
3nynSGVG protein-coupled receptor kinase 62.7.11.160.490
2c69CT8Cyclin-dependent kinase 22.7.11.220.489
3tnwF18Cyclin-dependent kinase 22.7.11.220.489
2r3gSC9Cyclin-dependent kinase 22.7.11.220.488
3unj0BXCyclin-dependent kinase 22.7.11.220.488
3qqlX03Cyclin-dependent kinase 22.7.11.220.487
3qziX72Cyclin-dependent kinase 22.7.11.220.487
4kd11QKCyclin-dependent kinase 22.7.11.220.487
1h1pCMGCyclin-dependent kinase 22.7.11.220.486
2vttLZDCyclin-dependent kinase 22.7.11.220.486
3nup3NUCyclin-dependent kinase 62.7.11.220.486
1oirHDYCyclin-dependent kinase 22.7.11.220.485
2c6iDT1Cyclin-dependent kinase 22.7.11.220.484
1b39ATPCyclin-dependent kinase 22.7.11.220.483
2pvnP63Casein kinase II subunit alpha2.7.11.10.483
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.482
3uli1N3Cyclin-dependent kinase 22.7.11.220.482
1fvv107Cyclin-dependent kinase 22.7.11.220.481
2vtrLZBCyclin-dependent kinase 22.7.11.220.480
2cchATPCyclin-dependent kinase 22.7.11.220.479
2w17I19Cyclin-dependent kinase 22.7.11.220.479
1aq1STUCyclin-dependent kinase 22.7.11.220.477
1vyzN5BCyclin-dependent kinase 22.7.11.220.477
2bhhRYUCyclin-dependent kinase 22.7.11.220.477
2r3r6SCCyclin-dependent kinase 22.7.11.220.477
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.477
4fko20KCyclin-dependent kinase 22.7.11.220.477
3nux3NVCyclin-dependent kinase 62.7.11.220.476
3pxyJWSCyclin-dependent kinase 22.7.11.220.476
3qrtX14Cyclin-dependent kinase 22.7.11.220.476
3ql8X01Cyclin-dependent kinase 22.7.11.220.475
4fkw62KCyclin-dependent kinase 22.7.11.220.475
2bheBRYCyclin-dependent kinase 22.7.11.220.474
2exmZIPCyclin-dependent kinase 22.7.11.220.474
4bcnT9NCyclin-dependent kinase 22.7.11.220.474
2pvlP55Casein kinase II subunit alpha2.7.11.10.471
3ggfGVDSerine/threonine-protein kinase 26/0.471
3my5RFZCyclin-dependent kinase 22.7.11.220.471
1ke9LS5Cyclin-dependent kinase 22.7.11.220.470
2c4g514Cyclin-dependent kinase 22.7.11.220.470
2y9qANPMitogen-activated protein kinase 12.7.11.240.470
4fkg4CKCyclin-dependent kinase 22.7.11.220.470
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.470
2csnCKICasein kinase I homolog 12.7.11.10.469
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.469
4bcqTJFCyclin-dependent kinase 22.7.11.220.468
2eufLQQCyclin-dependent kinase 62.7.11.220.467
3r8pZ46Cyclin-dependent kinase 22.7.11.220.467
4fklCK2Cyclin-dependent kinase 22.7.11.220.467
4ogrADNCyclin-dependent kinase 92.7.11.220.467
2c6mDT5Cyclin-dependent kinase 22.7.11.220.466
2r3fSC8Cyclin-dependent kinase 22.7.11.220.466
3py0SU9Cyclin-dependent kinase 22.7.11.220.466
3r9oZ71Cyclin-dependent kinase 22.7.11.220.466
4eol1ROCyclin-dependent kinase 22.7.11.220.466
4ez50RSCyclin-dependent kinase 62.7.11.220.466
2i40BLZCyclin-dependent kinase 22.7.11.220.464
2r3o2SCCyclin-dependent kinase 22.7.11.220.464
2x1nX1NCyclin-dependent kinase 22.7.11.220.464
3dogNNNCyclin-dependent kinase 22.7.11.220.464
3r9nZ68Cyclin-dependent kinase 22.7.11.220.464
3r8uZ31Cyclin-dependent kinase 22.7.11.220.463
3wblPDYCyclin-dependent kinase 22.7.11.220.463
1h0vUN4Cyclin-dependent kinase 22.7.11.220.462
2ds11CDCyclin-dependent kinase 22.7.11.220.462
2f2cAP9Cyclin-dependent kinase 62.7.11.220.462
2uzbC75Cyclin-dependent kinase 22.7.11.220.462
1pkdUCNCyclin-dependent kinase 22.7.11.220.461
4hgt15GCasein kinase I isoform delta2.7.11.10.461
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.460
4jrnANPRhoptry kinase family protein/0.459
2c6kDT2Cyclin-dependent kinase 22.7.11.220.458
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.457
3qzfX66Cyclin-dependent kinase 22.7.11.220.456
3sheI85MAP kinase-activated protein kinase 32.7.11.10.456
2c6lDT4Cyclin-dependent kinase 22.7.11.220.455
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.455
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.455
1gij2PUCyclin-dependent kinase 22.7.11.220.454
3r9hZ67Cyclin-dependent kinase 22.7.11.220.454
3rpy27ZCyclin-dependent kinase 22.7.11.220.454
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.454
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.453
3rzb02ZCyclin-dependent kinase 22.7.11.220.452
4eomATPCyclin-dependent kinase 22.7.11.220.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2c5nCK8Cyclin-dependent kinase 22.7.11.220.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
2uzlC94Cyclin-dependent kinase 22.7.11.220.450
3lq5SLQCyclin-dependent kinase 92.7.11.220.450
3qtwX3ACyclin-dependent kinase 22.7.11.220.450
2c68CT6Cyclin-dependent kinase 22.7.11.220.449
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.449
4jajXU1Aurora kinase A2.7.11.10.449
5dr9SKEAurora kinase A2.7.11.10.449
2b53D23Cyclin-dependent kinase 22.7.11.220.448
3rpr25ZCyclin-dependent kinase 22.7.11.220.448
5dr6SKEAurora kinase A2.7.11.10.448
4e6d0NUTyrosine-protein kinase JAK2/0.447
1pxjCK2Cyclin-dependent kinase 22.7.11.220.446
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.446
2uzeC95Cyclin-dependent kinase 22.7.11.220.446
3r8zZ63Cyclin-dependent kinase 22.7.11.220.446
4ic7ANPMitogen-activated protein kinase 72.7.11.240.446
1unhIXMCyclin-dependent-like kinase 52.7.11.10.445
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.445
2bkzSBCCyclin-dependent kinase 22.7.11.220.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
3a60STURibosomal protein S6 kinase beta-12.7.11.10.444
4ei40Q2Tyrosine-protein kinase JAK1/0.444
4fv9E71Mitogen-activated protein kinase 12.7.11.240.444
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
4e4n0NLTyrosine-protein kinase JAK1/0.443
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.442
1dm2HMDCyclin-dependent kinase 22.7.11.220.441
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.440