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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4lxb7R9Prothrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4lxb7R9Prothrombin3.4.21.51.000
1xm1GAHProthrombin3.4.21.50.701
3c1kT15Prothrombin3.4.21.50.657
2jh5895Prothrombin3.4.21.50.643
4ayy9MXProthrombin3.4.21.50.639
1d4pBPPProthrombin3.4.21.50.627
1sb1165Prothrombin3.4.21.50.625
4loy6XSProthrombin3.4.21.50.623
2bvs2CEProthrombin3.4.21.50.621
4ax9N5NProthrombin3.4.21.50.621
1ta6177Prothrombin3.4.21.50.619
2v3oI26Prothrombin3.4.21.50.615
2gdeSN3Prothrombin3.4.21.50.614
2zi224UProthrombin3.4.21.50.614
2zda32UProthrombin3.4.21.50.613
2zhe13UProthrombin3.4.21.50.610
1ypgUIRProthrombin3.4.21.50.608
1ypjUIBProthrombin3.4.21.50.608
1d6w00RProthrombin3.4.21.50.606
1z71L17Prothrombin3.4.21.50.603
2zc922UProthrombin3.4.21.50.600
1nm6L86Prothrombin3.4.21.50.598
2cn0F25Prothrombin3.4.21.50.598
2zfr46UProthrombin3.4.21.50.598
2zfq45UProthrombin3.4.21.50.597
2anmCDOProthrombin3.4.21.50.595
1k21IGNProthrombin3.4.21.50.594
1oytFSNProthrombin3.4.21.50.593
1ypeUIPProthrombin3.4.21.50.592
1ypkCCRProthrombin3.4.21.50.592
2zhf49UProthrombin3.4.21.50.592
2r2mI50Prothrombin3.4.21.50.591
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.591
1yplRA8Prothrombin3.4.21.50.589
1c4yIH3Prothrombin3.4.21.50.586
1mueCDDProthrombin3.4.21.50.584
1zgv501Prothrombin3.4.21.50.583
1d3dBZTProthrombin3.4.21.50.582
1c4uIH1Prothrombin3.4.21.50.581
1mu6CDAProthrombin3.4.21.50.580
1a4wQWEProthrombin3.4.21.50.579
1d3pBT3Prothrombin3.4.21.50.575
3qwc98PProthrombin3.4.21.50.575
2znk31UProthrombin3.4.21.50.574
2cf9348Prothrombin3.4.21.50.573
1t4v14AProthrombin3.4.21.50.571
1ypmRA4Prothrombin3.4.21.50.571
1zgi382Prothrombin3.4.21.50.571
4e7r0NWProthrombin3.4.21.50.571
1zrb062Prothrombin3.4.21.50.569
2zdv37UProthrombin3.4.21.50.566
2zgx29UProthrombin3.4.21.50.566
2zhw12UProthrombin3.4.21.50.566
2bdyUNBProthrombin3.4.21.50.565
4az29MUProthrombin3.4.21.50.565
2zhq27UProthrombin3.4.21.50.564
2cf8ESHProthrombin3.4.21.50.563
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.563
2jh0701Prothrombin3.4.21.50.562
2jh6894Prothrombin3.4.21.50.561
1d9i00PProthrombin3.4.21.50.560
1t4u81AProthrombin3.4.21.50.560
4rn615UProthrombin3.4.21.50.558
1w7gMIUProthrombin3.4.21.50.556
1ae8AZLProthrombin3.4.21.50.555
2zg050UProthrombin3.4.21.50.553
2pksG44Prothrombin3.4.21.50.552
1afeALZProthrombin3.4.21.50.550
2zfp19UProthrombin3.4.21.50.549
3eq02TSProthrombin3.4.21.50.548
1jwtBLIProthrombin3.4.21.50.546
4ayv9MQProthrombin3.4.21.50.546
4bamMM9Prothrombin3.4.21.50.546
2zf051UProthrombin3.4.21.50.543
1k22MELProthrombin3.4.21.50.541
3dux64UProthrombin3.4.21.50.540
2zgb21UProthrombin3.4.21.50.539
4n3l2FNProthrombin3.4.21.50.539
1riwOSCProthrombin3.4.21.50.535
1uvsI11Prothrombin3.4.21.50.535
1nzq162Prothrombin3.4.21.50.533
2uuk897Prothrombin3.4.21.50.533
3biu10UProthrombin3.4.21.50.532
2v3hI25Prothrombin3.4.21.50.526
2zff53UProthrombin3.4.21.50.523
1vzqSHYProthrombin3.4.21.50.522
1gj4132Prothrombin3.4.21.50.521
1mu8CDBProthrombin3.4.21.50.514
4bakM67Prothrombin3.4.21.50.514
4bahMELProthrombin3.4.21.50.509
3dhk23UProthrombin3.4.21.50.507
2uuj896Prothrombin3.4.21.50.505
3p1799PProthrombin3.4.21.50.502
2ziq26UProthrombin3.4.21.50.499
3egkM18Prothrombin3.4.21.50.499
1gj5130Prothrombin3.4.21.50.497
3qto10PProthrombin3.4.21.50.494
1o2g696Prothrombin3.4.21.50.493
3biv11UProthrombin3.4.21.50.493
1c4vIH2Prothrombin3.4.21.50.490
4baoMVFProthrombin3.4.21.50.490
5cmx0G6Prothrombin3.4.21.50.487
2a2xNA9Prothrombin3.4.21.50.485
4banM6SProthrombin3.4.21.50.484
3c27DKKProthrombin3.4.21.50.481
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.479
4baqM4ZProthrombin3.4.21.50.476
1o0d163Prothrombin3.4.21.50.467
3qtv06PProthrombin3.4.21.50.467
4kbyC2EStimulator of interferon genes protein/0.462
1bcuPRLProthrombin3.4.21.50.461
1ghv120Prothrombin3.4.21.50.456
1o5gCR9Prothrombin3.4.21.50.455
3utu1TSProthrombin3.4.21.50.455
4a802ANMajor pollen allergen Bet v 1-A/0.454
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.454
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.454
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.450
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.450
1umaIN2Prothrombin3.4.21.50.449
1c5nESIProthrombin3.4.21.50.441
2zsaADPPantothenate kinase2.7.1.330.440