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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4lucGDPGTPase KRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4lucGDPGTPase KRas/1.000
4l9sGDPGTPase HRas/0.580
3kkqGDPRas-related protein M-Ras/0.566
4lpkGDPGTPase KRas/0.562
4tq9GDPGTPase KRas/0.557
4xvrGNPGTPase HRas/0.525
3mjhGTPRas-related protein Rab-5A/0.524
2rggGNPGTPase HRas/0.523
4wa7GDPGTPase KRas/0.517
4lv6GDPGTPase KRas/0.507
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.506
3tgpGNPGTPase HRas/0.505
4o2rGDPGTP-binding protein Rheb/0.499
4q02GDPGTPase KRas/0.498
3k9lGNPGTPase HRas/0.497
4l8gGDPGTPase KRas/0.497
3qbtGNPRas-related protein Rab-8A/0.495
4ql3GDPGTPase KRas/0.495
3kkoGNPRas-related protein M-Ras/0.492
1x1rGDPRas-related protein M-Ras/0.491
4q03GDPGTPase KRas/0.489
2fe4GDPRas-related protein Rab-6B/0.484
4hdqGNPRas-related protein Rap-1b/0.483
4xvqGNPGTPase HRas/0.482
4epxGDPGTPase KRas/0.479
1n6lGTPRas-related protein Rab-5A/0.478
1uadGNPRas-related protein Ral-A/0.476
3pitGNPRas-related protein M-Ras/0.476
1lfdGNPGTPase HRas/0.471
4nyiGNPGTPase HRas/0.471
4dsnGCPGTPase KRas/0.470
4dsuGDPGTPase KRas/0.470
1tu3GNPRas-related protein Rab-5A/0.467
4g0nGNPGTPase HRas/0.465
3cphGDPRas-related protein SEC4/0.464
1zbdGTPRas-related protein Rab-3A/0.462
2mscGDPMHC class I alpha chain/0.461
3ddcGNPGTPase HRas/0.459
3i3sGNPGTPase HRas/0.459
4lrwGDPGTPase KRas/0.459
4epwGDPGTPase KRas/0.458
3oiwGNPGTPase HRas/0.457
4lhwGNPRas-related protein Rab-8A/0.457
1g16GDPRas-related protein SEC4/0.456
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.456
4nyjGNPGTPase HRas/0.455
3oesGNPGTPase RhebL1/0.454
3x1wGDPRas-related protein Rap-1b/0.454
4obeGDPGTPase KRas/0.454
3lbhGNPGTPase HRas/0.452
3tsoGNPRas-related protein Rab-25/0.452
1oixGDPRas-related protein Rab-11A/0.451
1zc4GNPRas-related protein Ral-A/0.451
2rgeGNPGTPase HRas/0.451
4uj5GNPRas-related protein Rab-11A/0.451
2ce2GDPGTPase HRas/0.449
3oivGNPGTPase HRas/0.447
4ldjGDPGTPase KRas/0.447
1zd9GDPADP-ribosylation factor-like protein 8A/0.446
4dltGNPGTPase HRas/0.446
2dftADPShikimate kinase2.7.1.710.445
5c46GSPRas-related protein Rab-11A/0.445
1zc3GNPRas-related protein Ral-A/0.443
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.442
4uj3GNPRas-related protein Rab-11A/0.442
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.441
2fg5GNPRas-related protein Rab-31/0.440
3v4fGNPGTPase HRas/0.440