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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ldjGDPGTPase KRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ldjGDPGTPase KRas/1.000
4ql3GDPGTPase KRas/0.809
4epxGDPGTPase KRas/0.782
4q03GDPGTPase KRas/0.759
4q02GDPGTPase KRas/0.643
4lpkGDPGTPase KRas/0.613
4tq9GDPGTPase KRas/0.613
4l8gGDPGTPase KRas/0.607
3kkqGDPRas-related protein M-Ras/0.600
2fe4GDPRas-related protein Rab-6B/0.592
4obeGDPGTPase KRas/0.591
4epwGDPGTPase KRas/0.582
4o2rGDPGTP-binding protein Rheb/0.582
4lv6GDPGTPase KRas/0.578
2rggGNPGTPase HRas/0.576
3kkoGNPRas-related protein M-Ras/0.575
4l9sGDPGTPase HRas/0.575
1x1rGDPRas-related protein M-Ras/0.574
4wa7GDPGTPase KRas/0.572
4dsuGDPGTPase KRas/0.567
3rs5GNPGTPase HRas/0.557
3k9lGNPGTPase HRas/0.556
4lucGDPGTPase KRas/0.556
3i3sGNPGTPase HRas/0.553
1uadGNPRas-related protein Ral-A/0.552
4lrwGDPGTPase KRas/0.552
3ddcGNPGTPase HRas/0.551
4hdqGNPRas-related protein Rap-1b/0.549
2rgbGNPGTPase HRas/0.548
4xvqGNPGTPase HRas/0.548
3tsoGNPRas-related protein Rab-25/0.546
3oivGNPGTPase HRas/0.545
4dltGNPGTPase HRas/0.544
2ce2GDPGTPase HRas/0.541
3cphGDPRas-related protein SEC4/0.540
3lbhGNPGTPase HRas/0.540
4lhwGNPRas-related protein Rab-8A/0.540
3rslGNPGTPase HRas/0.538
3x1zGNPRas-related protein Rap-1b/0.538
2c5lGTPGTPase HRas/0.537
3tgpGNPGTPase HRas/0.537
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.535
1zbdGTPRas-related protein Rab-3A/0.532
3rs4GNPGTPase HRas/0.532
4dsnGCPGTPase KRas/0.532
4g0nGNPGTPase HRas/0.532
4dlxGNPGTPase HRas/0.531
4xvrGNPGTPase HRas/0.531
2bmeGNPRas-related protein Rab-4A/0.529
2fg5GNPRas-related protein Rab-31/0.528
3v4fGNPGTPase HRas/0.528
3l8yGNPGTPase HRas/0.526
4dlvGNPGTPase HRas/0.526
5difGNPGTP-binding nuclear protein Ran/0.525
5dhaGNPGTP-binding nuclear protein Ran/0.524
3rs0GNPGTPase HRas/0.523
2rgcGNPGTPase HRas/0.522
3mjhGTPRas-related protein Rab-5A/0.522
3oiuGNPGTPase HRas/0.522
3w3zGTPGTP-binding nuclear protein Ran/0.522
4uj3GNPRas-related protein Rab-11A/0.522
1d5cGDPGTPase (Rab6)/0.520
1e96GTPRas-related C3 botulinum toxin substrate 1/0.520
1zd9GDPADP-ribosylation factor-like protein 8A/0.519
2mscGDPMHC class I alpha chain/0.519
3pitGNPRas-related protein M-Ras/0.519
3qbtGNPRas-related protein Rab-8A/0.519
4dlwGNPGTPase HRas/0.519
5b2zGNPGTPase HRas/0.519
4dlzGNPGTPase HRas/0.517
4nyjGNPGTPase HRas/0.516
1rd4L08Integrin alpha-L/0.515
1zc4GNPRas-related protein Ral-A/0.515
3lbnGNPGTPase HRas/0.515
4k81GTPGTPase HRas/0.514
3lbiGNPGTPase HRas/0.513
3kudGDPGTPase HRas/0.512
1z2aGDPRas-related protein Rab-23/0.511
2oo7AP5Adenylate kinase/0.510
1kmqGNPTransforming protein RhoA/0.507
2rgeGNPGTPase HRas/0.507
4uj5GNPRas-related protein Rab-11A/0.507
3bbpGTPRas-related protein Rab-6A/0.506
3oiwGNPGTPase HRas/0.506
3rs7GNPGTPase HRas/0.506
3x1wGDPRas-related protein Rap-1b/0.505
3cobADPKinesin heavy chain-like protein/0.504
1lfdGNPGTPase HRas/0.503
1oixGDPRas-related protein Rab-11A/0.503
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.503
3kucGDPRas-related protein Rap-1A/0.503
4nyiGNPGTPase HRas/0.503
1xtsGTPGTP-binding protein Rheb/0.501
4dxaGSPRas-related protein Rap-1b/0.501
4hdoGNPRas-related protein Rap-1b/0.501
1zc3GNPRas-related protein Ral-A/0.499
1e0jANPDNA primase/helicase2.7.70.498
1g16GDPRas-related protein SEC4/0.498
1yu9GNPRas-related protein Rab-4A/0.498
4dlsGNPGTPase HRas/0.498
4p9dTMPDeoxycytidylate deaminase/0.496
5jljGNPGTP-binding nuclear protein Ran/0.496
1n6lGTPRas-related protein Rab-5A/0.494
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.494
3k8yGNPGTPase HRas/0.494
1pqc444Oxysterols receptor LXR-beta/0.493
5c46GSPRas-related protein Rab-11A/0.493
4dsoGSPGTPase KRas/0.492
1bk0ACVIsopenicillin N synthase1.21.3.10.490
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.489
4kgkGTPUncharacterized protein/0.489
4rkfGNPRas-related protein Rab-3/0.489
1qrsATPGlutamine--tRNA ligase6.1.1.180.488
2y6fM9FIsopenicillin N synthase1.21.3.10.487
5hpyGDPTransforming protein RhoA/0.486
2nnqT4BFatty acid-binding protein, adipocyte/0.484
3rabGNPRas-related protein Rab-3A/0.484
4a81DXCMajor pollen allergen Bet v 1-A/0.484
1yhnGTPRas-related protein Rab-7a/0.483
1a4rGNHCell division control protein 42 homolog/0.482
2w6oOA3Biotin carboxylase6.3.4.140.482
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.482
4l9wGNPGTPase HRas/0.482
1ibrGNPGTP-binding nuclear protein Ran/0.481
1pq944BOxysterols receptor LXR-beta/0.481
1vyrFMNPentaerythritol tetranitrate reductase/0.481
3vhxGTPADP-ribosylation factor 6/0.481
4qxaGTPRas-related protein Rab-9A/0.481
1blzACVIsopenicillin N synthase1.21.3.10.479
2msdGNPMHC class I alpha chain/0.479
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.479
4iaq2GM5-hydroxytryptamine receptor 1B/0.479
2bkuGTPGTP-binding nuclear protein Ran/0.478
3p67FMNPentaerythritol tetranitrate reductase/0.478
4iarERM5-hydroxytryptamine receptor 1B/0.477
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.477
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.477
1z0aGDPRas-related protein Rab-2A/0.476
2cl6CAGGTPase HRas/0.476
3nbzGTPGTP-binding nuclear protein Ran/0.476
4h9753SDihydrofolate reductase1.5.1.30.476
1s1cGNPTransforming protein RhoA/0.475
1vg8GNPRas-related protein Rab-7a/0.475
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.475
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.475
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.473
2gilGTPRas-related protein Rab-6A/0.473
2p2mPRXAcetyl-coenzyme A synthetase/0.473
3a6pGTPGTP-binding nuclear protein Ran/0.473
4l8u9AZSerum albumin/0.473
1cxzGSPTransforming protein RhoA/0.472
1tkaN3TTransketolase 12.2.1.10.472
2c2aADPSensor histidine kinase/0.472
2iviACWIsopenicillin N synthase1.21.3.10.472
2wo7ASVIsopenicillin N synthase1.21.3.10.472
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.472
3zeiAWHO-acetylserine sulfhydrylase/0.472
4frkDWDBeta-secretase 13.4.23.460.472
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.472
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.471
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.471
4o2lGTPGTP-binding protein Rheb/0.471
1t91GTPRas-related protein Rab-7a/0.470
2rqfJH3Hemolymph juvenile hormone binding protein/0.470
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3gwdNAPCyclohexanone monooxygenase/0.470
3lqfNADGalactitol dehydrogenase/0.470
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.470
1bzfTMQDihydrofolate reductase1.5.1.30.469
1g17GNPRas-related protein SEC4/0.469
1hb1OCVIsopenicillin N synthase1.21.3.10.469
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.469
1y9dTPPPyruvate oxidase1.2.3.30.469
2jb4A14Isopenicillin N synthase1.21.3.10.469
4cidANPEH domain-containing protein 2/0.469
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
4mv1ADPBiotin carboxylase6.3.4.140.469
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.469
1yzqGNPRas-related protein Rab-6A/0.468
2l0xGDPGTP-binding protein Rheb/0.468
2zetGTPRas-related protein Rab-27B/0.468
2zitNADExotoxin A2.4.2.360.468
1n83CLRNuclear receptor ROR-alpha/0.467
1s3vTQDDihydrofolate reductase1.5.1.30.467
1x1dSAHC-20 methyltransferase/0.467
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
2dhfDZFDihydrofolate reductase1.5.1.30.467
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.467
3eg5GNPCell division control protein 42 homolog/0.467
3zoiM2WIsopenicillin N synthase1.21.3.10.467
4bb3KKAIsopenicillin N synthase1.21.3.10.467
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.466
1hb3SCVIsopenicillin N synthase1.21.3.10.466
2ffqGSPRas-related protein Rab-6B/0.466
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.466
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.466
3aosJH2Hemolymph juvenile hormone binding protein/0.466
3bc1GNPRas-related protein Rab-27A/0.466
3d84NDPDihydrofolate reductase1.5.1.30.466
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.466
4giu636Anthranilate phosphoribosyltransferase/0.466
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.466
4px9ADPATP-dependent RNA helicase DDX3X3.6.4.130.466
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1am4GNPCell division control protein 42 homolog/0.465
1g6oADPCag alpha/0.465
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.465
1ow3GDPTransforming protein RhoA/0.465
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.465
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.465
4wxxSAHDNA (cytosine-5)-methyltransferase 12.1.1.370.465
5iqiGNPBifunctional AAC/APH2.3.10.465
1pg3PRXAcetyl-coenzyme A synthetase/0.464
3ekuCY9Actin-5C/0.464
4a8v2ANMajor pollen allergen Bet v 1-J/0.464
4e2yJHZMethyltransferase/0.464
4n3l2FNProthrombin3.4.21.50.464
1cqp803Integrin alpha-L/0.463
1nw5SAMModification methylase RsrI2.1.1.720.463
1z0dGDPRas-related protein Rab-5C/0.463
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.463
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.463
4b4w9L9Bifunctional protein FolD/0.463
4cw5FMNDfnA/0.463
4itrGDPCell division control protein 42 homolog/0.463
4ixd1HVIntegrin alpha-L/0.463
4q71FADBifunctional protein PutA/0.463
1k22MELProthrombin3.4.21.50.462
1rx8FOLDihydrofolate reductase1.5.1.30.462
1w06W05Isopenicillin N synthase1.21.3.10.462
2q9fC3SCholesterol 24-hydroxylase/0.462
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.462
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3ig6438Urokinase-type plasminogen activator3.4.21.730.462
3ry2BTNStreptavidin/0.462
3tdaPN0Cytochrome P450 2D6/0.462
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.462
3vv8B02Beta-secretase 13.4.23.460.462
3wv9FEGHmd co-occurring protein HcgE/0.462
4r21STRCytochrome P450 family 17 polypeptide 2/0.462
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.462
1kquBR4Phospholipase A2, membrane associated/0.461
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.461
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.461
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.461
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
5ifiPRXAcetyl-coenzyme A synthetase/0.461
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.460
1z7yAA5Cysteine synthase 12.5.1.470.460
2oegUPGUDP-glucose pyrophosphorylase/0.460
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.460
4js0GNPCell division control protein 42 homolog/0.460
4xguADPPutative pachytene checkpoint protein 2/0.460
1db48INPhospholipase A2, membrane associated/0.459
1ia3TQ5Dihydrofolate reductase1.5.1.30.459
3b78NADExotoxin A2.4.2.360.459
3kz1GSPTransforming protein RhoA/0.459
3oafOAGDihydrofolate reductase1.5.1.30.459
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
4an4DUDPutative glycosyl transferase/0.459
4i1nFOLDihydrofolate reductase1.5.1.30.459
4loh1SYStimulator of interferon genes protein/0.459
5dn1AMZPhosphoribosyl isomerase A5.3.1.160.459
5k2aZMAAdenosine receptor A2a/0.459
1f5fDHTSex hormone-binding globulin/0.458
1pd9CO4Dihydrofolate reductase1.5.1.30.458
1qiqACCIsopenicillin N synthase1.21.3.10.458
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3wagTYDGlycosyltransferase/0.458
4cf7ADPAdenylate kinase/0.458
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.458
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.458
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.458
4kvgGTPRas-related protein Rap-1A/0.458
4rww2BALmo2692 protein/0.458
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.458
1njaDCMThymidylate synthase/0.457
1vf2GTXGlutathione S-transferase 32.5.1.180.457
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.457
3a1l2CCCytochrome P450/0.457
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3ea5GDPGTP-binding nuclear protein Ran/0.457
4mitGTPRho-related protein racC/0.457
4o1mNADEnoyl-acyl carrier reductase/0.457
5iu86DZAdenosine receptor A2a/0.457
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.456
2y66N04UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.456
3af4GCPPantothenate kinase2.7.1.330.456
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.456
3giyFMN(S)-mandelate dehydrogenase1.1.99.310.456
3hpqAP5Adenylate kinase/0.456
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.456
3oesGNPGTPase RhebL1/0.456
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.456
4b722FBBeta-secretase 13.4.23.460.456
1cdeGARPhosphoribosylglycinamide formyltransferase/0.455
1ii6ADPKinesin-like protein KIF11/0.455
1nm6L86Prothrombin3.4.21.50.455
1xtrGNPGTP-binding protein Rheb/0.455
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.455
2wpxACOOrf14/0.455
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.455
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.455
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.455
4g8bHL6Alpha/beta hydrolase fold protein/0.455
4g95OAGDihydrofolate reductase1.5.1.30.455
4irnFADAnaB/0.455
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4tx9AMZPhosphoribosyl isomerase A/0.455
5iqaGNPBifunctional AAC/APH2.3.10.455
1oc1ASVIsopenicillin N synthase1.21.3.10.454
1wklATPNucleoside diphosphate kinase/0.454
1ygjRMCPyridoxal kinase2.7.1.350.454
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.454
2j9lATPH(+)/Cl(-) exchange transporter 5/0.454
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
3oqfS51Renin3.4.23.150.454
3tnfGNPRas-related protein Rab-8A/0.454
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1ia4TQ6Dihydrofolate reductase1.5.1.30.453
1mmkH4BPhenylalanine-4-hydroxylase1.14.16.10.453
1ot7CHCBile acid receptor/0.453
2xlpFADPutative flavin-containing monooxygenase/0.453
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.453
3lawGNPRas-related protein Rab-7a/0.453
3lfcZ86Mitogen-activated protein kinase 14/0.453
3s1dZIRCytokinin dehydrogenase 11.5.99.120.453
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.453
4acuQN7Beta-secretase 13.4.23.460.453
4b78KGGBeta-secretase 13.4.23.460.453
4dc0NDPPutative ketoacyl reductase1.3.10.453
4ej1FOLDihydrofolate reductase1.5.1.30.453
4imfSI3N-acetylneuraminate lyase/0.453
4krs1SXTankyrase-12.4.2.300.453
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.453
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.453
1txtCAAHMG-CoA synthase/0.452
2az3CDPNucleoside diphosphate kinase/0.452
2c29NAPDihydroflavonol 4-reductase/0.452
2gpjFADSiderophore-interacting protein/0.452
2idkC2FGlycine N-methyltransferase2.1.1.200.452
2oz57XYUncharacterized protein/0.452
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.452
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.452
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.452
4jicFMNGTN Reductase/0.452
5iqdGNPBifunctional AAC/APH2.3.10.452
1gtrATPGlutamine--tRNA ligase6.1.1.180.451
1k5dGNPGTP-binding nuclear protein Ran/0.451
1klkPMDDihydrofolate reductase1.5.1.30.451
1wxjIPLTryptophan synthase alpha chain/0.451
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.451
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.451
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.451
2vn0TDZCytochrome P450 2C8/0.451
2wlfACOPolysialic acid O-acetyltransferase/0.451
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.451
2zsaADPPantothenate kinase2.7.1.330.451
3akm11DFatty acid-binding protein, intestinal/0.451
3dkvAP5Adenylate kinase/0.451
3k7mFAD6-hydroxy-L-nicotine oxidase/0.451
4a83DXCMajor pollen allergen Bet v 1-A/0.451
4ao4PLKBeta-transaminase/0.451
4dbzNDPPutative ketoacyl reductase1.3.10.451
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.451
4f5dC2EStimulator of interferon genes protein/0.451
4j491J1Uncharacterized protein/0.451
4jauADPSensor histidine kinase/0.451
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.451
5iqfGDPBifunctional AAC/APH2.3.10.451
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.450
1hvyD16Thymidylate synthase2.1.1.450.450
2h15B19Carbonic anhydrase 24.2.1.10.450
2vprTDCTetracycline repressor protein class H/0.450
2yimMC4Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.450
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
3biz61EWee1-like protein kinase2.7.10.20.450
3dl0AP5Adenylate kinase/0.450
3f0aACOSpermidine N(1)-acetyltransferase/0.450
3fmoADPATP-dependent RNA helicase DDX19B3.6.4.130.450
3fnlSHALactoperoxidase/0.450
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.450
3l0lHC3Nuclear receptor ROR-gamma/0.450
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.300.450
3wyfGTPGTP-binding nuclear protein/0.450
3zksWZVBeta-secretase 23.4.23.450.450
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.450
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.450
4opiFDAConserved Archaeal protein/0.450
4qbiAP5Adenylate kinase/0.450
4tkg09LTankyrase-22.4.2.300.450
5k2cZMAAdenosine receptor A2a/0.450
1dhfFOLDihydrofolate reductase1.5.1.30.449
1dr2TAPDihydrofolate reductase1.5.1.30.449
1ma0NADAlcohol dehydrogenase class-31.1.1.10.449
1mewXMPInosine-5'-monophosphate dehydrogenase/0.449
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.449
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.449
1ygkRRCPyridoxal kinase2.7.1.350.449
2f3rG5PGuanylate kinase2.7.4.80.449
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.449
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.449
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.449
3e5hGNPRas-related protein Rab-28/0.449
3fp0FP015-O-acetyltransferase/0.449
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.449
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.449
3p3zP3ZPutative cytochrome P450/0.449
3zkyWT4Isopenicillin N synthase1.21.3.10.449
4djw0KPBeta-secretase 13.4.23.460.449
4o25GTPGTP-binding protein Rheb/0.449
4z28BTNHoefavidin/0.449
5agyGTBTau class glutathione S-transferase/0.449
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.448
1c4yIH3Prothrombin3.4.21.50.448
1diuBDMDihydrofolate reductase1.5.1.30.448
1dr3HBIDihydrofolate reductase1.5.1.30.448
1kh3ANPArgininosuccinate synthase/0.448
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.448
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.448
1towCRZFatty acid-binding protein, adipocyte/0.448
1v8kANPKinesin-like protein KIF2C/0.448
2gcpGSPRho-related GTP-binding protein RhoC/0.448
2ok8FADFerredoxin--NADP reductase, apicoplast/0.448
2r2mI50Prothrombin3.4.21.50.448
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.448
2wvlGDDMannosyl-3-phosphogylcerate synthase/0.448
3kytHC2Nuclear receptor ROR-gamma/0.448
3lu8IQXSerum albumin/0.448
3w8wFADPutative FAD-dependent oxygenase EncM/0.448
3zkuHCVIsopenicillin N synthase1.21.3.10.448
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.448
4gutFADLysine-specific histone demethylase 1B10.448
4u0zAPCAdenosine monophosphate-protein transferase FICD2.7.7.n10.448
1d6w00RProthrombin3.4.21.50.447
1khrVIRStreptogramin A acetyltransferase2.3.10.447
1pvgANPDNA topoisomerase 25.99.1.30.447
1synF89Thymidylate synthase/0.447
1yhjR6CPyridoxal kinase2.7.1.350.447
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.447
2r6jNDPEugenol synthase 11.1.1.3180.447
2wlgSOPPolysialic acid O-acetyltransferase/0.447
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.447
2ylrNAPPhenylacetone monooxygenase1.14.13.920.447
2z9dFMNFMN-dependent NADH-azoreductase/0.447
3ag6PAJPantothenate synthetase/0.447
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.447
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3nxxNDPDihydrofolate reductase1.5.1.30.447
3w8fNAD3-hydroxybutyrate dehydrogenase/0.447
4nt3ZAWLactoperoxidase1.11.1.70.447
4rvgTYDD-mycarose 3-C-methyltransferase/0.447
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.447
4xr9NADCalS8/0.447
5jscFADPutative acyl-CoA dehydrogenase/0.447
5k2dZMAAdenosine receptor A2a/0.447
1m7bGTPRho-related GTP-binding protein RhoE/0.446
1obnASVIsopenicillin N synthase1.21.3.10.446
1qjfACSIsopenicillin N synthase1.21.3.10.446
1rx4DDFDihydrofolate reductase1.5.1.30.446
1xjjDGTVitamin B12-dependent ribonucleotide reductase/0.446
2a9z26AAdenosine kinase2.7.1.200.446
2aclL05Oxysterols receptor LXR-alpha/0.446
2bdyUNBProthrombin3.4.21.50.446
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.446
2on6IMHPurine nucleoside phosphorylase2.4.2.10.446
2vjmCOAFormyl-CoA:oxalate CoA-transferase/0.446
2xlrFADPutative flavin-containing monooxygenase/0.446
3d7zGK5Mitogen-activated protein kinase 14/0.446
3dejRXCCaspase-33.4.22.560.446
3k2fNKXCarbonic anhydrase 24.2.1.10.446
3mpeN2ACathepsin S3.4.22.270.446
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.446
3rgaILDEpoxide hydrolase LasB5.5.10.446
3s7a684Dihydrofolate reductase1.5.1.30.446
3sfdFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.446
3up0D7SaceDAF-12/0.446
4gh5NADShort-chain dehydrogenase/reductase SDR/0.446
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.446
1id0ANPSensor protein PhoQ2.7.13.30.445
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.445
1v35NAIEnoyl-ACP reductase/0.445
1ypkCCRProthrombin3.4.21.50.445
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.445
2dvlFADAcyl-CoA dehydrogenase/0.445
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.445
2v5aLZLBiotin carboxylase6.3.4.140.445
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.445
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.445
3iej599Cathepsin S3.4.22.270.445
3kq7KQ7Mitogen-activated protein kinase 14/0.445
3pndFADFAD:protein FMN transferase/0.445
4azy7F3Beta-secretase 13.4.23.460.445
4f3xNADPutative aldehyde dehydrogenase/0.445
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.445
4itfTFYVitamin D3 receptor/0.445
4l0oPLPCystathionine gamma-synthase2.5.1.480.445
4r1lADPPhenylacetate-coenzyme A ligase/0.445
4s1iPLPPyridoxal kinase, putative/0.445
4xoiGTPTransforming protein RhoA/0.445
5stdUNNScytalone dehydratase4.2.1.940.445
1aoeGW3Dihydrofolate reductase1.5.1.30.444
1d2sDHTSex hormone-binding globulin/0.444
1drfFOLDihydrofolate reductase1.5.1.30.444
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1mvtDTMDihydrofolate reductase1.5.1.30.444
2a5kAZPReplicase polyprotein 1ab3.4.220.444
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.444
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.444
2gvdFKPAdenylate cyclase type 2/0.444
2gvdFKPAdenylate cyclase type 5/0.444
2izfBTNStreptavidin/0.444
2vbdV10Isopenicillin N synthase1.21.3.10.444
2vbpVB1Isopenicillin N synthase1.21.3.10.444
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
3bgxMEFThymidylate synthase/0.444
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3qm4PN0Cytochrome P450 2D6/0.444
3w0aDS5Vitamin D3 receptor/0.444
4dijBLFE3 ubiquitin-protein ligase Mdm26.3.20.444
4q72FADBifunctional protein PutA/0.444
5cccDDFDihydrofolate reductase1.5.1.30.444
5iubCLRAdenosine receptor A2a/0.444
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1eioGCHGastrotropin/0.443
1orrCDPCDP-paratose 2-epimerase/0.443
2bvs2CEProthrombin3.4.21.50.443
2dvoITTdITP/XTP pyrophosphatase3.6.1.190.443
2hamC33Vitamin D3 receptor/0.443
2mseGNPMHC class I alpha chain/0.443
2pl0STITyrosine-protein kinase Lck2.7.10.20.443
2w6pOA4Biotin carboxylase6.3.4.140.443
2z4sADPChromosomal replication initiator protein DnaA/0.443
3aezGDPPantothenate kinase2.7.1.330.443
3af1GDPPantothenate kinase2.7.1.330.443
3d4bDZDNAD-dependent protein deacetylase/0.443
3fhxPLPPyridoxal kinase2.7.1.350.443
3fr4F8AFatty acid-binding protein, adipocyte/0.443
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3maaFKPAdenylate cyclase type 2/0.443
3maaFKPAdenylate cyclase type 5/0.443
3oqkS52Renin3.4.23.150.443
3p74FMNPentaerythritol tetranitrate reductase/0.443
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.443
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
3w8eNAD3-hydroxybutyrate dehydrogenase/0.443
4at0FADPossible succinate dehydrogenase/0.443
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.443
4h1e10JBeta-secretase 13.4.23.460.443
4lzwTHMUridine phosphorylase/0.443
4r20AERCytochrome P450 family 17 polypeptide 2/0.443
4udqFAD5-(hydroxymethyl)furfural oxidase/0.443
1a42BZUCarbonic anhydrase 24.2.1.10.442
1dhiMTXDihydrofolate reductase1.5.1.30.442
1dhrNADDihydropteridine reductase1.5.1.340.442
1lvu9PPPurine nucleoside phosphorylase2.4.2.10.442
1rszDIHPurine nucleoside phosphorylase2.4.2.10.442
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2f6rACOBifunctional coenzyme A synthase/0.442
2pakTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.442
2q3fGNPRas-related GTP-binding protein D/0.442
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.442
2zynBCDPeriplasmic binding protein/0.442
3eej53RUncharacterized protein/0.442
3id8MRKGlucokinase2.7.1.20.442
3ntz3TZDihydrofolate reductase1.5.1.30.442
3phiNDPShikimate dehydrogenase (NADP(+))/0.442
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.442
3wthIM4Acetylcholine-binding protein/0.442
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.442
4awtFMNNADH:flavin oxidoreductase Sye1/0.442
4dc32FAPutative adenosine kinase/0.442
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.442
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.442
4lb2DM5Serum albumin/0.442
4mkgAP5Adenylate kinase/0.442
4nteFADDepH/0.442
4y9lFADAcyl-CoA dehydrogenase family member 11/0.442
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.442
5dp2NAPCurF/0.442
5f8eSAHPossible transcriptional regulatory protein/0.442
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.442
5li5THR_ALA_ASN_PRO_SEPKLTH0G14146p/0.442
1al7HSTPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.441
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1gxfFADTrypanothione reductase1.8.1.120.441
1hfqMOTDihydrofolate reductase1.5.1.30.441
1jedADPSulfate adenylyltransferase/0.441
1lwxAZDNucleoside diphosphate kinase, cytosolic2.7.4.60.441
1mueCDDProthrombin3.4.21.50.441
1p8dCO1Oxysterols receptor LXR-beta/0.441
1rj6AZMCarbonic anhydrase 144.2.1.10.441
1t2cNAIL-lactate dehydrogenase1.1.1.270.441
1t4v14AProthrombin3.4.21.50.441
1tu3GNPRas-related protein Rab-5A/0.441
1xzqFONtRNA modification GTPase MnmE3.6.50.441
2bjfDXCCholoylglycine hydrolase3.5.1.240.441
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.441
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.441
2zsbADPPantothenate kinase2.7.1.330.441
3cseN22Uncharacterized protein/0.441
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.441
3gwfNAPCyclohexanone monooxygenase/0.441
3jzdNADMaleylacetate reductase/0.441
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4bfxZVXPantothenate kinase2.7.1.330.441
4bfzZVZPantothenate kinase2.7.1.330.441
4fryNADPutative signal-transduction protein with CBS domains/0.441
4i111CHBeta-secretase 13.4.23.460.441
4i13FOLDihydrofolate reductase1.5.1.30.441
4kgnSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.441
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.441
4pnmNU1Tankyrase-22.4.2.300.441
4q73FADBifunctional protein PutA/0.441
4yqfGDPSeptin-9/0.441
1e2nRCAThymidine kinase/0.440
1hdrNADDihydropteridine reductase1.5.1.340.440
1ia1NDPDihydrofolate reductase1.5.1.30.440
1kt6RTLRetinol-binding protein 4/0.440
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.440
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.440
1szcCNANAD-dependent protein deacetylase HST23.5.10.440
1xm1GAHProthrombin3.4.21.50.440
1yplRA8Prothrombin3.4.21.50.440
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.440
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.440
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.440
2amb17HAndrogen receptor/0.440
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2dxdANPNucleoside diphosphate kinase2.7.4.60.440
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.440
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.440
2vo4GTB2,4-D inducible glutathione S-transferase/0.440
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.440
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.440
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.440
3ddw055Glycogen phosphorylase, liver form2.4.1.10.440
3p0eBAUUridine phosphorylase 22.4.2.30.440
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.440
3up3XCAaceDAF-12/0.440
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
4acxS8ZBeta-secretase 13.4.23.460.440
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.440
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.440
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.440
4nc3ERM5-hydroxytryptamine receptor 2B/0.440
4nevFADTrypanothione reductase/0.440
4orkGDPBifunctional AAC/APH2.3.10.440
4w5jAP5Adenylate kinase/0.440
5eccNAPDehydrofolate reductase type I/0.440
5iqbGNPBifunctional AAC/APH2.3.10.440