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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l9sGDPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l9sGDPGTPase HRas/1.000
4lucGDPGTPase KRas/0.635
4lpkGDPGTPase KRas/0.616
4wa7GDPGTPase KRas/0.613
4tq9GDPGTPase KRas/0.612
4epwGDPGTPase KRas/0.607
4l8gGDPGTPase KRas/0.605
4dltGNPGTPase HRas/0.596
3tgpGNPGTPase HRas/0.589
4dlwGNPGTPase HRas/0.585
4ql3GDPGTPase KRas/0.581
4q03GDPGTPase KRas/0.573
3lbhGNPGTPase HRas/0.572
4obeGDPGTPase KRas/0.567
4xvqGNPGTPase HRas/0.567
2rggGNPGTPase HRas/0.566
3kkqGDPRas-related protein M-Ras/0.561
4epxGDPGTPase KRas/0.561
4o2rGDPGTP-binding protein Rheb/0.560
4lv6GDPGTPase KRas/0.559
3v4fGNPGTPase HRas/0.556
2rgeGNPGTPase HRas/0.554
3qbtGNPRas-related protein Rab-8A/0.553
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.552
2fe4GDPRas-related protein Rab-6B/0.552
4hdqGNPRas-related protein Rap-1b/0.552
3tsoGNPRas-related protein Rab-25/0.550
4nyiGNPGTPase HRas/0.550
3mjhGTPRas-related protein Rab-5A/0.549
2mscGDPMHC class I alpha chain/0.548
4q02GDPGTPase KRas/0.548
3rslGNPGTPase HRas/0.547
3ddcGNPGTPase HRas/0.546
2ce2GDPGTPase HRas/0.545
3lbnGNPGTPase HRas/0.543
5b2zGNPGTPase HRas/0.542
2rgcGNPGTPase HRas/0.541
3k8yGNPGTPase HRas/0.541
4xvrGNPGTPase HRas/0.541
3oesGNPGTPase RhebL1/0.536
3rs4GNPGTPase HRas/0.536
1g16GDPRas-related protein SEC4/0.535
3i3sGNPGTPase HRas/0.535
3oivGNPGTPase HRas/0.535
2rgbGNPGTPase HRas/0.534
4ldjGDPGTPase KRas/0.533
1x1rGDPRas-related protein M-Ras/0.532
4dlzGNPGTPase HRas/0.532
3kkoGNPRas-related protein M-Ras/0.531
3l8yGNPGTPase HRas/0.528
2cl6CAGGTPase HRas/0.527
3k9lGNPGTPase HRas/0.527
4qxaGTPRas-related protein Rab-9A/0.527
3lbiGNPGTPase HRas/0.524
3pitGNPRas-related protein M-Ras/0.524
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.524
2c5lGTPGTPase HRas/0.523
4dlvGNPGTPase HRas/0.522
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.521
4lrwGDPGTPase KRas/0.520
1zd9GDPADP-ribosylation factor-like protein 8A/0.518
4dsuGDPGTPase KRas/0.518
4lhwGNPRas-related protein Rab-8A/0.518
2bmeGNPRas-related protein Rab-4A/0.517
3rs0GNPGTPase HRas/0.516
3x1wGDPRas-related protein Rap-1b/0.514
1yu9GNPRas-related protein Rab-4A/0.513
3cphGDPRas-related protein SEC4/0.511
3oiuGNPGTPase HRas/0.510
4g0nGNPGTPase HRas/0.510
3oiwGNPGTPase HRas/0.509
2fg5GNPRas-related protein Rab-31/0.508
3w3zGTPGTP-binding nuclear protein Ran/0.508
4dsnGCPGTPase KRas/0.508
3rs5GNPGTPase HRas/0.507
4dlxGNPGTPase HRas/0.506
1uadGNPRas-related protein Ral-A/0.505
4uj3GNPRas-related protein Rab-11A/0.505
4nyjGNPGTPase HRas/0.501
1g17GNPRas-related protein SEC4/0.500
4hdoGNPRas-related protein Rap-1b/0.500
3a58GNPGTP-binding protein RHO1/0.498
1kmqGNPTransforming protein RhoA/0.494
3x1zGNPRas-related protein Rap-1b/0.494
1lfdGNPGTPase HRas/0.493
4rkfGNPRas-related protein Rab-3/0.493
5c46GSPRas-related protein Rab-11A/0.493
1yzqGNPRas-related protein Rab-6A/0.492
4k81GTPGTPase HRas/0.492
4uj5GNPRas-related protein Rab-11A/0.492
1n6lGTPRas-related protein Rab-5A/0.491
3e5hGNPRas-related protein Rab-28/0.490
4dxaGSPRas-related protein Rap-1b/0.490
1xtsGTPGTP-binding protein Rheb/0.489
1z2aGDPRas-related protein Rab-23/0.488
1zbdGTPRas-related protein Rab-3A/0.488
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.487
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.485
1e96GTPRas-related C3 botulinum toxin substrate 1/0.483
1cxzGSPTransforming protein RhoA/0.482
3kucGDPRas-related protein Rap-1A/0.482
3kudGDPGTPase HRas/0.482
3rs7GNPGTPase HRas/0.480
1t91GTPRas-related protein Rab-7a/0.479
1tu3GNPRas-related protein Rab-5A/0.479
1ibrGNPGTP-binding nuclear protein Ran/0.478
1a2bGSPTransforming protein RhoA/0.477
4dsoGSPGTPase KRas/0.477
5dhaGNPGTP-binding nuclear protein Ran/0.477
1zc4GNPRas-related protein Ral-A/0.476
3a6pGTPGTP-binding nuclear protein Ran/0.476
1z0aGDPRas-related protein Rab-2A/0.475
5jljGNPGTP-binding nuclear protein Ran/0.473
3rabGNPRas-related protein Rab-3A/0.472
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.472
1zc3GNPRas-related protein Ral-A/0.471
2msdGNPMHC class I alpha chain/0.470
2gcpGSPRho-related GTP-binding protein RhoC/0.469
3tnfGNPRas-related protein Rab-8A/0.469
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.466
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.466
4l9wGNPGTPase HRas/0.466
4o2lGTPGTP-binding protein Rheb/0.466
4mitGTPRho-related protein racC/0.465
1ky2GNPGTP-binding protein YPT7/0.464
2q3fGNPRas-related GTP-binding protein D/0.464
4cidANPEH domain-containing protein 2/0.464
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.463
2yg4FADPutrescine oxidase/0.462
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.461
2ffqGSPRas-related protein Rab-6B/0.460
2gilGTPRas-related protein Rab-6A/0.458
1d5cGDPGTPase (Rab6)/0.457
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.457
4d0lGSPRas-related protein Rab-11A/0.457
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.456
5difGNPGTP-binding nuclear protein Ran/0.452
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.452
1n83CLRNuclear receptor ROR-alpha/0.451
1xtrGNPGTP-binding protein Rheb/0.449
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.449
3kz1GSPTransforming protein RhoA/0.449
2iutAGSDNA translocase FtsK/0.448
3bbpGTPRas-related protein Rab-6A/0.448
1m7bGTPRho-related GTP-binding protein RhoE/0.447
2ok7FADFerredoxin--NADP reductase, apicoplast/0.447
4dlsGNPGTPase HRas/0.447
4itrGDPCell division control protein 42 homolog/0.447
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.446
3fvqATPFe(3+) ions import ATP-binding protein FbpC/0.446
3refGDPRho family GTPase/0.445
1pq944BOxysterols receptor LXR-beta/0.444
1yhnGTPRas-related protein Rab-7a/0.444
3eg5GNPCell division control protein 42 homolog/0.444
4kvgGTPRas-related protein Rap-1A/0.444
1am4GNPCell division control protein 42 homolog/0.443
1ii6ADPKinesin-like protein KIF11/0.443
1tysDHFThymidylate synthase/0.443
3nbzGTPGTP-binding nuclear protein Ran/0.443
3vhxGTPADP-ribosylation factor 6/0.443
1vg8GNPRas-related protein Rab-7a/0.442
2j0vGDPRac-like GTP-binding protein ARAC7/0.442
2mseGNPMHC class I alpha chain/0.442
1khbGCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.440
1v8kANPKinesin-like protein KIF2C/0.440
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.440