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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l8gGDPGTPase KRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4l8gGDPGTPase KRas/1.000
4l9sGDPGTPase HRas/0.686
2rggGNPGTPase HRas/0.647
4lpkGDPGTPase KRas/0.642
4q02GDPGTPase KRas/0.640
4lucGDPGTPase KRas/0.634
4lv6GDPGTPase KRas/0.633
4tq9GDPGTPase KRas/0.629
4lrwGDPGTPase KRas/0.628
4xvqGNPGTPase HRas/0.626
4epwGDPGTPase KRas/0.622
4epxGDPGTPase KRas/0.622
4wa7GDPGTPase KRas/0.621
2ce2GDPGTPase HRas/0.619
4q03GDPGTPase KRas/0.614
2fe4GDPRas-related protein Rab-6B/0.613
4hdqGNPRas-related protein Rap-1b/0.608
4obeGDPGTPase KRas/0.608
3tgpGNPGTPase HRas/0.603
3lbhGNPGTPase HRas/0.602
4ldjGDPGTPase KRas/0.602
3kkoGNPRas-related protein M-Ras/0.599
3kkqGDPRas-related protein M-Ras/0.593
2rgeGNPGTPase HRas/0.591
2fg5GNPRas-related protein Rab-31/0.590
4o2rGDPGTP-binding protein Rheb/0.590
3lbnGNPGTPase HRas/0.589
4ql3GDPGTPase KRas/0.588
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.586
3k9lGNPGTPase HRas/0.585
4nyiGNPGTPase HRas/0.585
3ddcGNPGTPase HRas/0.582
4dxaGSPRas-related protein Rap-1b/0.581
3v4fGNPGTPase HRas/0.576
3qbtGNPRas-related protein Rab-8A/0.575
4xvrGNPGTPase HRas/0.575
3rs4GNPGTPase HRas/0.572
2cl6CAGGTPase HRas/0.571
4nyjGNPGTPase HRas/0.569
3x1wGDPRas-related protein Rap-1b/0.568
3rs5GNPGTPase HRas/0.566
4dlwGNPGTPase HRas/0.565
2rgcGNPGTPase HRas/0.564
3k8yGNPGTPase HRas/0.563
3oivGNPGTPase HRas/0.563
4dsuGDPGTPase KRas/0.562
3tsoGNPRas-related protein Rab-25/0.558
4dlxGNPGTPase HRas/0.558
2rgbGNPGTPase HRas/0.557
4l9wGNPGTPase HRas/0.557
5dhaGNPGTP-binding nuclear protein Ran/0.557
4dlvGNPGTPase HRas/0.555
4dlzGNPGTPase HRas/0.555
2mscGDPMHC class I alpha chain/0.554
4dltGNPGTPase HRas/0.553
5jljGNPGTP-binding nuclear protein Ran/0.550
2bmeGNPRas-related protein Rab-4A/0.548
2c5lGTPGTPase HRas/0.547
3oiwGNPGTPase HRas/0.547
3lbiGNPGTPase HRas/0.546
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.546
1uadGNPRas-related protein Ral-A/0.545
3i3sGNPGTPase HRas/0.545
3pitGNPRas-related protein M-Ras/0.545
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.543
3l8yGNPGTPase HRas/0.543
3rs0GNPGTPase HRas/0.543
4dsnGCPGTPase KRas/0.543
4g0nGNPGTPase HRas/0.541
5c46GSPRas-related protein Rab-11A/0.539
1xtsGTPGTP-binding protein Rheb/0.538
3mjhGTPRas-related protein Rab-5A/0.537
4cidANPEH domain-containing protein 2/0.537
5difGNPGTP-binding nuclear protein Ran/0.537
4lhwGNPRas-related protein Rab-8A/0.536
1cxzGSPTransforming protein RhoA/0.535
1t91GTPRas-related protein Rab-7a/0.533
1zc4GNPRas-related protein Ral-A/0.532
1kmqGNPTransforming protein RhoA/0.526
3x1zGNPRas-related protein Rap-1b/0.526
1z0aGDPRas-related protein Rab-2A/0.525
3oiuGNPGTPase HRas/0.525
1tu3GNPRas-related protein Rab-5A/0.522
4dlsGNPGTPase HRas/0.522
3a58GNPGTP-binding protein RHO1/0.521
1e96GTPRas-related C3 botulinum toxin substrate 1/0.519
1yzqGNPRas-related protein Rab-6A/0.519
1lfdGNPGTPase HRas/0.518
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.518
4k81GTPGTPase HRas/0.518
1zd9GDPADP-ribosylation factor-like protein 8A/0.517
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.517
3rslGNPGTPase HRas/0.516
5b2zGNPGTPase HRas/0.516
3kudGDPGTPase HRas/0.515
4uj5GNPRas-related protein Rab-11A/0.514
3e5hGNPRas-related protein Rab-28/0.513
3cphGDPRas-related protein SEC4/0.512
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.511
4uj3GNPRas-related protein Rab-11A/0.510
1n6lGTPRas-related protein Rab-5A/0.508
3rs7GNPGTPase HRas/0.508
4dsoGSPGTPase KRas/0.508
1g17GNPRas-related protein SEC4/0.507
1yu9GNPRas-related protein Rab-4A/0.507
1zc3GNPRas-related protein Ral-A/0.507
4qxaGTPRas-related protein Rab-9A/0.507
4rkfGNPRas-related protein Rab-3/0.507
1oixGDPRas-related protein Rab-11A/0.506
1z2aGDPRas-related protein Rab-23/0.505
3kucGDPRas-related protein Rap-1A/0.504
1x1rGDPRas-related protein M-Ras/0.502
4o2lGTPGTP-binding protein Rheb/0.501
1zbdGTPRas-related protein Rab-3A/0.500
1d5cGDPGTPase (Rab6)/0.497
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.497
3oesGNPGTPase RhebL1/0.495
4xg1LLPDiaminopimelate decarboxylase/0.493
5iqaGNPBifunctional AAC/APH2.3.10.493
1ii6ADPKinesin-like protein KIF11/0.491
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.491
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.490
2bkuGTPGTP-binding nuclear protein Ran/0.490
4d0lGSPRas-related protein Rab-11A/0.490
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.489
3bbpGTPRas-related protein Rab-6A/0.489
1a2bGSPTransforming protein RhoA/0.488
3a6pGTPGTP-binding nuclear protein Ran/0.488
4itrGDPCell division control protein 42 homolog/0.488
2iutAGSDNA translocase FtsK/0.486
4hdoGNPRas-related protein Rap-1b/0.486
5iqbGNPBifunctional AAC/APH2.3.10.486
1gwnGTPRho-related GTP-binding protein RhoE/0.485
1s1cGNPTransforming protein RhoA/0.485
3eg5GNPCell division control protein 42 homolog/0.484
2gcpGSPRho-related GTP-binding protein RhoC/0.483
3kz1GSPTransforming protein RhoA/0.483
1yhnGTPRas-related protein Rab-7a/0.482
1am4GNPCell division control protein 42 homolog/0.480
1xtrGNPGTP-binding protein Rheb/0.480
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.480
2mseGNPMHC class I alpha chain/0.479
3rabGNPRas-related protein Rab-3A/0.479
5iqdGNPBifunctional AAC/APH2.3.10.479
1m7bGTPRho-related GTP-binding protein RhoE/0.478
3gkjHC3Niemann-Pick C1 protein/0.478
3w3zGTPGTP-binding nuclear protein Ran/0.477
1ibrGNPGTP-binding nuclear protein Ran/0.476
1ow3GDPTransforming protein RhoA/0.476
1eqgIBPProstaglandin G/H synthase 11.14.99.10.475
3tnfGNPRas-related protein Rab-8A/0.475
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.475
2gilGTPRas-related protein Rab-6A/0.474
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.474
4xoiGTPTransforming protein RhoA/0.474
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.473
1k5dGNPGTP-binding nuclear protein Ran/0.472
1v8kANPKinesin-like protein KIF2C/0.472
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.470
2msdGNPMHC class I alpha chain/0.470
2q3fGNPRas-related GTP-binding protein D/0.469
3vhxGTPADP-ribosylation factor 6/0.469
3wyfGTPGTP-binding nuclear protein/0.469
5i67GDPPhosphoenolpyruvate carboxykinase [GTP]/0.469
1ky2GNPGTP-binding protein YPT7/0.468
4js0GNPCell division control protein 42 homolog/0.467
1g16GDPRas-related protein SEC4/0.466
1n83CLRNuclear receptor ROR-alpha/0.466
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.466
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.466
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.466
5iu86DZAdenosine receptor A2a/0.466
3pghFLPProstaglandin G/H synthase 21.14.99.10.465
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.465
1a4rGNHCell division control protein 42 homolog/0.464
1powFADPyruvate oxidase1.2.3.30.464
5hpyGDPTransforming protein RhoA/0.462
1vg8GNPRas-related protein Rab-7a/0.461
2zpaADPtRNA(Met) cytidine acetyltransferase TmcA/0.461
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.460
4mitGTPRho-related protein racC/0.460
5k2bZMAAdenosine receptor A2a/0.460
2vo4GTB2,4-D inducible glutathione S-transferase/0.459
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.459
3copADPGlycogen synthase2.4.1.210.459
2vprTDCTetracycline repressor protein class H/0.458
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.458
3th5GNPRas-related C3 botulinum toxin substrate 1/0.458
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.458
3bc1GNPRas-related protein Rab-27A/0.457
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.457
5iqgGDPBifunctional AAC/APH2.3.10.457
5kf2COAPredicted acetyltransferase/0.457
2ffqGSPRas-related protein Rab-6B/0.456
2wpwACOOrf14/0.456
4ag7COAGlucosamine 6-phosphate N-acetyltransferase/0.456
1z0dGDPRas-related protein Rab-5C/0.455
1ht834CProstaglandin G/H synthase 11.14.99.10.454
2clsGTPRho-related GTP-binding protein Rho6/0.454
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4y0vGDPADP-ribosylation factor 1, putative/0.454
5uviZMAAdenosine receptor A2a/0.454
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.453
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.453
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.452
1s0xC3SNuclear receptor ROR-alpha/0.452
2bxqIMNSerum albumin/0.452
2dvlFADAcyl-CoA dehydrogenase/0.452
2j0vGDPRac-like GTP-binding protein ARAC7/0.452
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4fidGDPG protein alpha subunit, putative/0.452
1rd4L08Integrin alpha-L/0.451
1vcfFMNIsopentenyl-diphosphate delta-isomerase/0.451
2dpxGDPGTP-binding protein RAD/0.451
4cjqVXOIntegrase/0.451
5iubCLRAdenosine receptor A2a/0.451
5k2dZMAAdenosine receptor A2a/0.451
3emlZMAAdenosine receptor A2a/0.451
2bgjFADNADPH:ferredoxin reductase/0.450
2c29NAPDihydroflavonol 4-reductase/0.450
2zetGTPRas-related protein Rab-27B/0.450
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.450
4pkl1GHUncharacterized protein/0.450
5bylGCPBifunctional AAC/APH2.3.10.450
5k2cZMAAdenosine receptor A2a/0.450
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
4kvgGTPRas-related protein Rap-1A/0.449
4ol0GTPGTP-binding nuclear protein Ran/0.449
5iqeGNPBifunctional AAC/APH2.3.10.449
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.448
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
1eqhFLPProstaglandin G/H synthase 11.14.99.10.447
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.447
2vcmM11Isopenicillin N synthase1.21.3.10.447
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.447
1ia3TQ5Dihydrofolate reductase1.5.1.30.446
1poxFADPyruvate oxidase1.2.3.30.446
1z2cGNPRho-related GTP-binding protein RhoC/0.446
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.446
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.446
3ea5GDPGTP-binding nuclear protein Ran/0.446
3fgoCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
4hi0GDPUrease accessory protein UreG/0.446
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.446
5djuFMNNPH1-2/0.446
5dozNDPJamJ/0.446
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.445
5di3GNPADP-ribosylation factor-like protein 3/0.445
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.445
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.444
2pupADPMethylthioribose kinase2.7.1.1000.444
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.444
3q7dNPXProstaglandin G/H synthase 21.14.99.10.444
5iqiGNPBifunctional AAC/APH2.3.10.444
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1wdtGTPElongation factor G (EF-G-2)/0.443
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.443
3d4bDZDNAD-dependent protein deacetylase/0.443
3up3XCAaceDAF-12/0.443
4jdaA9SAbscisic acid receptor PYL3/0.443
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.443
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.443
1cdeGARPhosphoribosylglycinamide formyltransferase/0.442
1fgxU5PBeta-1,4-galactosyltransferase 1/0.442
2bbqPFGThymidylate synthase/0.442
3is9AC7Gag-Pol polyprotein2.7.7.490.442
3q5dGDPAtlastin-13.6.50.442
4bewCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4y9lFADAcyl-CoA dehydrogenase family member 11/0.442
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2glxNDP1,5-anhydro-D-fructose reductase/0.441
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.441
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.441
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.441
4o25GTPGTP-binding protein Rheb/0.441
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1njaDCMThymidylate synthase/0.440
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4ceqQCHIntegrase/0.440
4g01GDPRas-related protein RABF2b/0.440
4tx9AMZPhosphoribosyl isomerase A/0.440
4ylgGDPADP-ribosylation factor 1, putative/0.440