sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.681 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.630 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.627 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.622 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.614 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.602 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.601 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.599 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.596 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.596 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.595 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.591 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.589 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.589 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.588 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.587 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.585 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.573 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.573 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.563 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.541 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.522 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.497 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.497 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.494 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.493 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.492 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.488 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.487 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.486 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.485 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.484 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.483 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.482 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.480 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.479 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.478 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.478 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.478 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.476 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.475 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.474 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.472 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.469 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.467 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.466 | |
| 4egn | TWO | Cytochrome P450 | / | 0.465 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.464 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.463 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.461 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.461 | |
| 5a3c | NAD | SIR2 family protein | / | 0.460 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.456 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.456 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 3u9e | COA | Lmo1369 protein | / | 0.454 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.454 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.454 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.453 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.452 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.450 | |
| 3flz | FLZ | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.450 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.449 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.448 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.447 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.445 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.444 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 3zuy | TCH | Transporter | / | 0.442 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.442 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.441 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.441 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.441 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.440 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.440 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 |