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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l4cCAMCamphor 5-monooxygenase1.14.15.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4l4cCAMCamphor 5-monooxygenase1.14.15.11.000
3wrmCAMCamphor 5-monooxygenase1.14.15.10.843
3fwgCAMCamphor 5-monooxygenase1.14.15.10.828
3wrlCAMCamphor 5-monooxygenase1.14.15.10.784
3fwfCAMCamphor 5-monooxygenase1.14.15.10.738
3wrhCAMCamphor 5-monooxygenase1.14.15.10.723
3wrjCAMCamphor 5-monooxygenase1.14.15.10.721
3l63CAMCamphor 5-monooxygenase1.14.15.10.688
4l49CAMCamphor 5-monooxygenase1.14.15.10.682
1dz4CAMCamphor 5-monooxygenase1.14.15.10.677
5cp4CAMCamphor 5-monooxygenase1.14.15.10.671
1t86CAMCamphor 5-monooxygenase1.14.15.10.669
1dz6CAMCamphor 5-monooxygenase1.14.15.10.668
1t88CAMCamphor 5-monooxygenase1.14.15.10.668
2zawCAMCamphor 5-monooxygenase1.14.15.10.667
3fwjCAMCamphor 5-monooxygenase1.14.15.10.666
1t85CAMCamphor 5-monooxygenase1.14.15.10.664
3fwiCAMCamphor 5-monooxygenase1.14.15.10.659
1yrdCAMCamphor 5-monooxygenase1.14.15.10.656
2cppCAMCamphor 5-monooxygenase1.14.15.10.654
2zaxCAMCamphor 5-monooxygenase1.14.15.10.654
1iwjCAMCamphor 5-monooxygenase1.14.15.10.652
2m56CAMCamphor 5-monooxygenase1.14.15.10.652
4l4bCAMCamphor 5-monooxygenase1.14.15.10.649
1iwiCAMCamphor 5-monooxygenase1.14.15.10.648
1nooCAHCamphor 5-monooxygenase1.14.15.10.648
1t87CAMCamphor 5-monooxygenase1.14.15.10.648
6cp4CAMCamphor 5-monooxygenase1.14.15.10.648
4cp4CAMCamphor 5-monooxygenase1.14.15.10.647
1phgMYTCamphor 5-monooxygenase1.14.15.10.646
4ek1CAMCamphor 5-monooxygenase1.14.15.10.645
1yrcCAMCamphor 5-monooxygenase1.14.15.10.644
4g3rCAMCamphor 5-monooxygenase1.14.15.10.644
1gebCAMCamphor 5-monooxygenase1.14.15.10.637
1o76CAMCamphor 5-monooxygenase1.14.15.10.636
2a1oCAMCamphor 5-monooxygenase1.14.15.10.635
3cppCAMCamphor 5-monooxygenase1.14.15.10.635
4l4dCAMCamphor 5-monooxygenase1.14.15.10.635
4kkyCAMCamphor 5-monooxygenase1.14.15.10.634
1dz8CAMCamphor 5-monooxygenase1.14.15.10.631
2qbmCAMCamphor 5-monooxygenase1.14.15.10.630
2a1mCAMCamphor 5-monooxygenase1.14.15.10.628
2feuCAMCamphor 5-monooxygenase1.14.15.10.628
2qboCAMCamphor 5-monooxygenase1.14.15.10.628
2qbnCAMCamphor 5-monooxygenase1.14.15.10.627
4l4fCAMCamphor 5-monooxygenase1.14.15.10.627
2z97CAMCamphor 5-monooxygenase1.14.15.10.626
1uyuCAMCamphor 5-monooxygenase1.14.15.10.625
2a1nCAMCamphor 5-monooxygenase1.14.15.10.625
4l4aCAMCamphor 5-monooxygenase1.14.15.10.622
4l4eCAMCamphor 5-monooxygenase1.14.15.10.617
4jx1CAMCamphor 5-monooxygenase1.14.15.10.614
2qblCAMCamphor 5-monooxygenase1.14.15.10.612
2zuiCAMCamphor 5-monooxygenase1.14.15.10.611
1phePIYCamphor 5-monooxygenase1.14.15.10.600
4c9pCAMCytochrome P450/0.597
4jx1CAHCamphor 5-monooxygenase1.14.15.10.593
3lxiCAMCytochrome P450/0.589
1rf9DBRCamphor 5-monooxygenase1.14.15.10.549
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.531
4c9oCAMCytochrome P450/0.520
4j6bPLOCytochrome P450 monooxygenase/0.520
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.517
1eupASD6-deoxyerythronolide B hydroxylase/0.516
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.516
4j6cSTRCytochrome P450 monooxygenase/0.515
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.514
1jioDEB6-deoxyerythronolide B hydroxylase/0.507
4y8wSTRSteroid 21-hydroxylase/0.505
4r20AERCytochrome P450 family 17 polypeptide 2/0.503
5hs1VORLanosterol 14-alpha demethylase/0.500
3mdvCL6Cholesterol 24-hydroxylase/0.497
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.497
1t2bCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.495
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.495
4tuvCPZCytochrome P450 1191.140.495
4uymVOR14-alpha sterol demethylase Cyp51B/0.494
4enhFVXCholesterol 24-hydroxylase/0.487
2ft9CHDFatty acid-binding protein 2, liver/0.485
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.485
4j6dTESCytochrome P450 monooxygenase/0.485
3p3zP3ZPutative cytochrome P450/0.481
3cv9VDXVitamin D3 dihydroxylase/0.480
4i8vBHFCytochrome P450 1A11.14.14.10.480
2vn0TDZCytochrome P450 2C8/0.479
1pkfEPDEpothilone C/D epoxidase1.140.478
3zk5Z18Cytochrome P450 monooxygenase PikC/0.478
3qm4PN0Cytochrome P450 2D6/0.476
3t3r9PLCytochrome P450 2A61.14.130.475
3tk3CPZCytochrome P450 2B41.14.14.10.475
3ibdCPZCytochrome P450 2B61.14.130.473
3a1l2CCCytochrome P450/0.472
3p99LNPLanosterol 14-alpha-demethylase/0.471
3tdaPN0Cytochrome P450 2D6/0.471
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.471
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.469
4jbtASDCytochrome P450 monooxygenase/0.469
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.468
3ns2PYVAbscisic acid receptor PYL2/0.468
4cdmFO1Deoxyribodipyrimidine photolyase/0.467
3s79ASDAromatase1.14.14.140.466
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.466
2q9fC3SCholesterol 24-hydroxylase/0.465
1og5SWFCytochrome P450 2C9/0.464
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.464
3nxuRITCytochrome P450 3A4/0.464
2rkvZBATrichothecene 3-O-acetyltransferase/0.463
1m13HYFNuclear receptor subfamily 1 group I member 2/0.462
2z3uCRRCytochrome P450/0.462
1jipKTN6-deoxyerythronolide B hydroxylase/0.461
3t3q9PLCytochrome P450 2A61.14.130.461
3tjsD0RCytochrome P450 3A4/0.461
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.461
1fmjRTLRetinol dehydratase/0.460
1q5dEPBEpothilone C/D epoxidase1.140.460
3lqfNADGalactitol dehydrogenase/0.460
3triNAPPyrroline-5-carboxylate reductase/0.460
4g3jVNTLanosterol 14-alpha-demethylase/0.460
3flzFLZMitogen-activated protein kinase 14/0.459
4aacAAVMitogen-activated protein kinase 14/0.459
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
4e5yNDPGDP-L-fucose synthase1.1.1.2710.459
1tdrMTXDihydrofolate reductase1.5.1.30.458
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.458
3nr4PYVAbscisic acid receptor PYL2/0.458
4g1z0VPVitamin D3 receptor A/0.458
4r21STRCytochrome P450 family 17 polypeptide 2/0.458
1bl6SB6Mitogen-activated protein kinase 14/0.457
1bwsNDPGDP-L-fucose synthase/0.457
1suoCPZCytochrome P450 2B41.14.14.10.457
3cseN22Uncharacterized protein/0.457
3fskRO6Mitogen-activated protein kinase 14/0.457
3w9rA8SAbscisic acid receptor PYL9/0.457
2drcMTXDihydrofolate reductase1.5.1.30.456
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.456
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2wpxACOOrf14/0.455
3gobHXXDdmC/0.455
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
3drcMTXDihydrofolate reductase1.5.1.30.454
3w6hAZMCarbonic anhydrase 14.2.1.10.454
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.454
1k6cMK1Gag-Pol polyprotein3.4.23.160.453
1k6tXN1Gag-Pol polyprotein3.4.23.160.453
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.453
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.453
2zbaZBATrichothecene 3-O-acetyltransferase/0.453
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.453
3nnuEDBMitogen-activated protein kinase 14/0.453
3vrwYS5Vitamin D3 receptor/0.453
3csdEMOPutative ketoacyl reductase1.3.10.452
3flwFLWMitogen-activated protein kinase 14/0.452
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
1ek2CDUBifunctional epoxide hydrolase 2/0.451
2nnhREACytochrome P450 2C8/0.451
3cgdNADCoenzyme A disulfide reductase/0.451
3kf7L9GMitogen-activated protein kinase 14/0.451
3zuyTCHTransporter/0.451
4n6hEJ4Delta-type opioid receptor/0.451
1fmlRTLRetinol dehydratase/0.450
2cy0NAPShikimate dehydrogenase (NADP(+))/0.450
2lbaCHOFatty acid binding protein 6/0.450
2y3sTIRTamL/0.450
3eej53RUncharacterized protein/0.450
3oafOAGDihydrofolate reductase1.5.1.30.450
4z34ON7Lysophosphatidic acid receptor 1/0.450
3nj0PYVAbscisic acid receptor PYL2/0.449
3vtdTKDVitamin D3 receptor/0.449
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.449
1klkPMDDihydrofolate reductase1.5.1.30.448
1ouy094Mitogen-activated protein kinase 14/0.448
1u3dFADCryptochrome-1/0.448
2vzmNRBCytochrome P450 monooxygenase PikC/0.448
3slkNDPPolyketide synthase extender module 2/0.448
3u9eCOALmo1369 protein/0.448
4a9hTVPBromodomain-containing protein 2/0.448
4egnTWOCytochrome P450/0.448
4ejgNCTCytochrome P450 2A131.14.14.10.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.447
3njoP2MAbscisic acid receptor PYR1/0.447
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.447
4l9q9TPSerum albumin/0.447
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1owpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.446
1tw4CHDFatty acid-binding protein, liver/0.446
1vzdCB3Thymidylate synthase/0.446
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.446
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.446
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
3mdmFJZCholesterol 24-hydroxylase/0.446
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4h9814QUncharacterized protein/0.446
4i6gFADCryptochrome-2/0.446
4zcaADPKinesin-like protein KIF11/0.446
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
2bxmIMNSerum albumin/0.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
3ibqATPPyridoxal kinase/0.445
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.445
4h9506UDihydrofolate reductase1.5.1.30.445
4iteTEYVitamin D3 receptor/0.445
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.445
5c7oNADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific1.2.1.120.445
1cjkFOKAdenylate cyclase type 2/0.444
1cjkFOKAdenylate cyclase type 5/0.444
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.444
1k6vXN2Gag-Pol polyprotein3.4.23.160.444
1ouk084Mitogen-activated protein kinase 14/0.444
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.444
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.444
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.444
3eem53VUncharacterized protein/0.444
3ol5SAWCamphor 5-monooxygenase1.14.15.10.444
4elg52JDihydrofolate reductase/0.444
4ia1BIVVitamin D3 receptor A/0.444
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.443
2y3rTRKTamL/0.443
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.443
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3p8jFMNPentaerythritol tetranitrate reductase/0.443
3pm0BHFCytochrome P450 1B1/0.443
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.443
4xiwAZMCarbonic anhydrase, alpha type/0.443
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1rm4NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.442
2c6hPXICytochrome P450 monooxygenase PikC/0.442
2hcdBIVVitamin D3 receptor A/0.442
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
4a9mP9MBromodomain-containing protein 2/0.442
4g7gVFVLanosterol 14-alpha-demethylase/0.442
4nmdFDABifunctional protein PutA/0.442
4o761M3Bromodomain-containing protein 4/0.442
1dhjMTXDihydrofolate reductase1.5.1.30.441
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2qg4NADUDP-glucose 6-dehydrogenase1.1.1.220.441
2y3rTIRTamL/0.441
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.441
3atzFMNProstaglandin F2a synthase/0.441
4ejh0QACytochrome P450 2A131.14.14.10.441
4nm9FADBifunctional protein PutA/0.441
4zowCLMMultidrug transporter MdfA/0.441
1nzdUPGDNA beta-glucosyltransferase/0.440
1o9bNAIQuinate/shikimate dehydrogenase/0.440
1rf7DHFDihydrofolate reductase1.5.1.30.440
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.440
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.440
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.440
4h9614QDihydrofolate reductase1.5.1.30.440
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440