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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.101.000
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.654
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.580
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.575
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.572
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.550
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.531
3iczPB6Farnesyl pyrophosphate synthase/0.516
3egt722Farnesyl pyrophosphate synthase/0.485
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.467
5emhNAPIridoid synthase1.3.1.990.462
3rywK9HFarnesyl pyrophosphate synthase, putative/0.456
4l5b1UXDeoxycytidine kinase2.7.1.740.456
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.448
1zdwFLVPrenyltransferase/0.444
3tdaPN0Cytochrome P450 2D6/0.444
1fm4DXCMajor pollen allergen Bet v 1-L/0.442
4az3S35Lysosomal protective protein3.4.16.50.442
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.441
2ixbNADAlpha-N-acetylgalactosaminidase3.2.1.490.440