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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l2g1V4Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l2g1V4Tankyrase-22.4.2.301.000
4bueJQFTankyrase-22.4.2.300.789
4l0t1V0Tankyrase-22.4.2.300.774
4buxF35Tankyrase-22.4.2.300.736
4hlh20DTankyrase-22.4.2.300.717
4bs4A64Tankyrase-22.4.2.300.699
4bus32FTankyrase-22.4.2.300.677
4buwF33Tankyrase-22.4.2.300.674
4l0s1UZTankyrase-22.4.2.300.646
4buuF38Tankyrase-22.4.2.300.639
4l2k1V8Tankyrase-22.4.2.300.637
4kzl20DTankyrase-22.4.2.300.635
4l0v1V1Tankyrase-22.4.2.300.635
4l341VGTankyrase-22.4.2.300.635
4bu908CTankyrase-22.4.2.300.631
4hkkAGITankyrase-22.4.2.300.630
4kzuA73Tankyrase-22.4.2.300.626
4l0i1UWTankyrase-22.4.2.300.621
4hlf15ZTankyrase-22.4.2.300.618
4l10A63Tankyrase-22.4.2.300.618
5aku29FTankyrase-22.4.2.300.618
4buiW2ETankyrase-22.4.2.300.617
4hlk431Tankyrase-22.4.2.300.617
4hl515WTankyrase-22.4.2.300.616
4bufF36Tankyrase-22.4.2.300.604
3kr8XAVTankyrase-22.4.2.300.602
4bud29FTankyrase-22.4.2.300.602
4but31FTankyrase-22.4.2.300.599
4iueAJ4Tankyrase-22.4.2.300.599
4l31F08Tankyrase-22.4.2.300.595
4hlm16STankyrase-22.4.2.300.589
4l2f1V3Tankyrase-22.4.2.300.588
4l321VFTankyrase-22.4.2.300.586
4j22AJ7Tankyrase-22.4.2.300.577
4hlg20BTankyrase-22.4.2.300.575
4l33F70Tankyrase-22.4.2.300.575
4j21AJ6Tankyrase-22.4.2.300.574
4avwG18Tankyrase-22.4.2.300.571
3p0pNNFTankyrase-22.4.2.300.569
4hmhF94Tankyrase-22.4.2.300.562
4hknLU2Tankyrase-22.4.2.300.553
4hkiFLNTankyrase-22.4.2.300.537
4bjbP34Tankyrase-22.4.2.300.534
4krs1SXTankyrase-12.4.2.300.527
4avuLDRTankyrase-22.4.2.300.519
4msk2C8Tankyrase-12.4.2.300.505
4l091URTankyrase-22.4.2.300.495
4pnmNU1Tankyrase-22.4.2.300.493
4pnrG18Tankyrase-22.4.2.300.492
1x8lOXRRetinol dehydratase/0.478
4bj9UHBTankyrase-22.4.2.300.470
3qm4PN0Cytochrome P450 2D6/0.466
4j3lAJ5Tankyrase-22.4.2.300.464
4buv16ITankyrase-22.4.2.300.463
4tjy3GNTankyrase-22.4.2.300.460
1opbRETRetinol-binding protein 2/0.457
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.455
2bf7HBIPteridine reductase 11.5.1.330.452
1zgbA1EAcetylcholinesterase3.1.1.70.450
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.447
1fmlRTLRetinol dehydratase/0.446
3rsv3RSBeta-secretase 13.4.23.460.446
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.444
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.443
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.442
2f3815MAldo-keto reductase family 1 member C3/0.440
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440