scPDB - Distribution of Binding site Similarity values of 4ky4 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.791
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.535
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.529
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.513
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.511
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.506
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.498
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.497
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.491
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.489
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.483
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.480
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.471
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.467
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.466
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.462
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.462
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.460
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.458
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.456
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.456
3qly	55V	Uncharacterized protein	/	0.453
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.450
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.448
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.448
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.448
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.448
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.446
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.445
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.445
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.444
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.444
3cse	N22	Uncharacterized protein	/	0.443
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.443
2fs4	PZ1	Renin	3.4.23.15	0.440
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.440