sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ku2 | MYA | 3-oxoacyl-[ACP] synthase III |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ku2 | MYA | 3-oxoacyl-[ACP] synthase III | / | 1.000 | |
| 4ku3 | MYA | 3-oxoacyl-[ACP] synthase III | / | 0.618 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.611 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.469 | |
| 4xzm | NAP | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.468 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.462 | |
| 3wg6 | NDP | NADPH-dependent conjugated polyketone reductase C1 | / | 0.460 | |
| 3t9f | ADP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.459 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 1a5u | ATP | Pyruvate kinase PKM | 2.7.1.40 | 0.455 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.455 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.455 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 5c7h | NDP | Putative oxidoreductase | / | 0.454 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.453 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.453 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.452 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.452 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.452 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1hk2 | T44 | Serum albumin | / | 0.450 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.450 | |
| 3t99 | ADP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.450 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.449 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.447 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.447 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.446 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.446 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 3pef | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.444 | |
| 3s5w | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.443 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.443 | |
| 5doz | NDP | JamJ | / | 0.443 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.441 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.441 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.441 | |
| 4yvz | 3AT | DNA integrity scanning protein DisA | / | 0.441 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.440 |