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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.11.000
2cjmATPCyclin-dependent kinase 22.7.11.220.470
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.465
4y95746Tyrosine-protein kinase/0.464
4y93746Tyrosine-protein kinase/0.460
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.458
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.452
3zh8C58Protein kinase C iota type2.7.11.130.450
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.445
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
3i60E86Mitogen-activated protein kinase 12.7.11.240.441