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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4krs1SXTankyrase-12.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4krs1SXTankyrase-12.4.2.301.000
4tkg09LTankyrase-22.4.2.300.599
3u9y09LTankyrase-22.4.2.300.590
4pnrG18Tankyrase-22.4.2.300.531
4bj9UHBTankyrase-22.4.2.300.528
4j3mAJ8Tankyrase-22.4.2.300.522
4msk2C8Tankyrase-12.4.2.300.520
4l321VFTankyrase-22.4.2.300.501
2zitNADExotoxin A2.4.2.360.496
4li81XQTankyrase-12.4.2.300.492
4hlm16STankyrase-22.4.2.300.486
4i9i1DYTankyrase-12.4.2.300.482
4buxF35Tankyrase-22.4.2.300.479
4iueAJ4Tankyrase-22.4.2.300.479
4j21AJ6Tankyrase-22.4.2.300.478
3p0pNNFTankyrase-22.4.2.300.475
4avwG18Tankyrase-22.4.2.300.475
4bueJQFTankyrase-22.4.2.300.474
4bufF36Tankyrase-22.4.2.300.468
4l31F08Tankyrase-22.4.2.300.468
3b78NADExotoxin A2.4.2.360.466
4bjbP34Tankyrase-22.4.2.300.464
4l091URTankyrase-22.4.2.300.464
4l0i1UWTankyrase-22.4.2.300.464
4pnmNU1Tankyrase-22.4.2.300.464
4tjy3GNTankyrase-22.4.2.300.464
4li71XPTankyrase-12.4.2.300.463
4buwF33Tankyrase-22.4.2.300.462
4hlk431Tankyrase-22.4.2.300.460
2geuCOKPantothenate kinase2.7.1.330.459
4hmhF94Tankyrase-22.4.2.300.459
4l0s1UZTankyrase-22.4.2.300.459
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.458
4l0t1V0Tankyrase-22.4.2.300.458
4l33F70Tankyrase-22.4.2.300.458
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.456
4bu908CTankyrase-22.4.2.300.456
4mt92D6Tankyrase-12.4.2.300.453
4buuF38Tankyrase-22.4.2.300.452
5irnADPNucleotide binding oligomerization domain containing 2/0.452
4l2k1V8Tankyrase-22.4.2.300.449
4bs4A64Tankyrase-22.4.2.300.447
4l2g1V4Tankyrase-22.4.2.300.446
4msg2C6Tankyrase-12.4.2.300.446
4hlh20DTankyrase-22.4.2.300.445
2gevCOKPantothenate kinase2.7.1.330.444
4bud29FTankyrase-22.4.2.300.443
4l2f1V3Tankyrase-22.4.2.300.443
4l10A63Tankyrase-22.4.2.300.442
5aku29FTankyrase-22.4.2.300.442
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.441
4buv16ITankyrase-22.4.2.300.440
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.440