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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4krhSAMPhosphoethanolamine N-methyltransferase 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4krhSAMPhosphoethanolamine N-methyltransferase 2/1.000
4fgzSAHPhosphoethanolamine N-methyltransferase/0.547
3uj7SAMPhosphoethanolamine N-methyltransferase/0.515
4mwzSAMPhosphoethanolamine N-methyltransferase, putative/0.485
3uj8SFGPhosphoethanolamine N-methyltransferase/0.482
4r6xSAHPhosphoethanolamine N-methyltransferase/0.473
5icfSAH(S)-norcoclaurine 6-O-methyltransferase/0.457
4iv8SAMPhosphoethanolamine N-methyltransferase,putative/0.456
5epeSAHUncharacterized protein/0.453
5jr3SAHCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.447
4rv9SAHD-mycarose 3-C-methyltransferase/0.443
3kpjSAHPhenylethanolamine N-methyltransferase2.1.1.280.442