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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.101.000
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.666
4nkeIPEFarnesyl pyrophosphate synthase2.5.1.100.565
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.561
3ez3IPEFarnesyl pyrophosphate synthase, putative/0.553
3krfIPEGeranyl diphosphate synthase large subunit/0.503
1rqjIPEFarnesyl diphosphate synthase2.5.1.100.481
4lfgIPEPutative geranyltranstransferase/0.476