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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.623
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.607
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.592
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.577
1gerFADGlutathione reductase1.8.1.70.550
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.545
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.542
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.540
1grhFADGlutathione reductase, mitochondrial1.8.1.70.539
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.535
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.535
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.534
1grgFADGlutathione reductase, mitochondrial1.8.1.70.534
1greFADGlutathione reductase, mitochondrial1.8.1.70.532
3grsFADGlutathione reductase, mitochondrial1.8.1.70.532
2v6oFADThioredoxin glutathione reductase/0.525
1febFADTrypanothione reductase1.8.1.120.524
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.516
1graFADGlutathione reductase, mitochondrial1.8.1.70.511
2r9zFADGlutathione amide reductase/0.506
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.499
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.491
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.488
4nevFADTrypanothione reductase/0.487
4j56FADThioredoxin reductase 21.8.1.90.486
1zx9FADMercuric reductase1.16.1.10.482
1geuFADGlutathione reductase1.8.1.70.481
3ic9FADPutative dihydrolipoamide dehydrogenase/0.480
1zk7FADMercuric reductase1.16.1.10.479
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.478
4jq9FADDihydrolipoyl dehydrogenase/0.473
1feaFADTrypanothione reductase1.8.1.120.472
1bzlFADTrypanothione reductase1.8.1.120.470
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.467
2rabFADGlutathione amide reductase/0.466
3ladFADDihydrolipoyl dehydrogenase/0.463
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.459
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.458
1grbFADGlutathione reductase, mitochondrial1.8.1.70.457
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.455
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
2eq9FADDihydrolipoyl dehydrogenase/0.445
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.443
4la1FADThioredoxin glutathione reductase/0.440