sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4kow | CFX | Uncharacterized protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4kow | CFX | Uncharacterized protein | / | 1.000 | |
| 4koy | CSC | Uncharacterized protein | / | 0.624 | |
| 4kos | 4KO | Uncharacterized protein | / | 0.622 | |
| 4kov | KOV | Uncharacterized protein | / | 0.593 | |
| 4kou | C04 | Uncharacterized protein | / | 0.583 | |
| 4kot | CE3 | Uncharacterized protein | / | 0.579 | |
| 4klv | KLV | Uncharacterized protein | / | 0.558 | |
| 4kox | CLS | Uncharacterized protein | / | 0.556 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.498 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
| 3lpg | Z78 | Beta-glucuronidase | 3.2.1.31 | 0.478 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.474 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.469 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.463 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.456 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.456 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.455 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.454 | |
| 1j7u | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.453 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.450 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.447 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.447 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.445 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2uzf | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.444 | |
| 3nyr | MLC | Putative fatty acid synthase | / | 0.444 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.443 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.442 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.441 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.441 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.441 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.440 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 |