sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4kos | 4KO | Uncharacterized protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4kos | 4KO | Uncharacterized protein | / | 1.000 | |
| 4kot | CE3 | Uncharacterized protein | / | 0.676 | |
| 4kov | KOV | Uncharacterized protein | / | 0.668 | |
| 4kow | CFX | Uncharacterized protein | / | 0.621 | |
| 4kou | C04 | Uncharacterized protein | / | 0.616 | |
| 4koy | CSC | Uncharacterized protein | / | 0.616 | |
| 4kox | CLS | Uncharacterized protein | / | 0.614 | |
| 4klv | KLV | Uncharacterized protein | / | 0.526 | |
| 4i42 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.492 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.467 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.466 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.463 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.463 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.462 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.462 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.456 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1q51 | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.455 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.455 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.453 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.451 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.451 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.450 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.449 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.448 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.448 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.448 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.447 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.446 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.446 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.445 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.445 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.445 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 1j7u | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.444 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.444 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.444 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.443 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.442 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4c4o | NAD | SADH | / | 0.442 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.441 | |
| 1t57 | FMN | Conserved protein | / | 0.441 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.441 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.441 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.441 |