scPDB - Distribution of Binding site Similarity values of 4kne entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4kne	1CY	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4kne	1CY	Dihydrofolate reductase	1.5.1.3	1.000
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.522
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.511
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.497
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.496
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.493
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.492
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.491
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.488
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.483
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.482
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.481
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.478
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.478
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.478
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.475
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.474
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.473
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.472
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.471
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.469
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.469
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.468
4q72	FAD	Bifunctional protein PutA	/	0.468
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.465
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.464
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.463
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.463
4uyf	73B	Bromodomain-containing protein 2	/	0.460
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.459
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.458
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.457
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.455
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.454
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.454
5hi6	MTX	Dihydrofolate reductase	/	0.454
1ra3	MTX	Dihydrofolate reductase	1.5.1.3	0.453
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.453
4x5h	FOL	Dihydrofolate reductase	1.5.1.3	0.453
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.451
4q73	FAD	Bifunctional protein PutA	/	0.450
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.449
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.448
2h2q	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.447
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.446
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.445
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.445
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.445
2w9h	TOP	Dihydrofolate reductase	1.5.1.3	0.444
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.443
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.443
4hbm	0Y7	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.443
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.442
2fzn	FAD	Bifunctional protein PutA	1.5.5.2	0.442
3haz	FAD	Bifunctional protein PutA	/	0.442
1zmc	NAD	Dihydrolipoyl dehydrogenase, mitochondrial	1.8.1.4	0.440
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.440
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.440
3vvp	BNU	Uncharacterized protein	/	0.440
4dja	FAD	(6-4) photolyase	/	0.440