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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kn2LYAFolate receptor beta

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kn2LYAFolate receptor beta/1.000
4kn0MTXFolate receptor beta/0.607
4lrhFOLFolate receptor alpha/0.597
4kn104JFolate receptor beta/0.593
4kmzFOLFolate receptor beta/0.542
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.479
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.479
1ry8RUTAldo-keto reductase family 1 member C3/0.469
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.469
4nv10FXFormyl transferase/0.466
4b7zQ4QAcetylcholinesterase3.1.1.70.463
1q83TZ5Acetylcholinesterase3.1.1.70.462
4dbuBT9Aldo-keto reductase family 1 member C3/0.460
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.460
4fam0SZAldo-keto reductase family 1 member C3/0.457
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.456
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.456
2aouCQAHistamine N-methyltransferase2.1.1.80.455
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2f3815MAldo-keto reductase family 1 member C3/0.449
3v94WYQPhosphodiesterase/0.449
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.448
3n0hTOPDihydrofolate reductase1.5.1.30.448
1odcA8BAcetylcholinesterase3.1.1.70.447
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.447
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.447
1zgcA2EAcetylcholinesterase3.1.1.70.446
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.446
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.446
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.446
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.446
1ry0PG2Aldo-keto reductase family 1 member C3/0.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.444
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
1ut6A8NAcetylcholinesterase3.1.1.70.443
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.443
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.443
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.443
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.443
4dbw511Aldo-keto reductase family 1 member C3/0.442
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.441
2xufTZ4Acetylcholinesterase3.1.1.70.441
2xugTZ4Acetylcholinesterase3.1.1.70.441
1rkwPNTHTH-type transcriptional regulator QacR/0.440
2cekN8TAcetylcholinesterase3.1.1.70.440
2xupTZ5Acetylcholinesterase3.1.1.70.440
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.440