scPDB - Distribution of Binding site Similarity values of 4kd7 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4kd7	9DR	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	1.000
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.658
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.642
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.626
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.592
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.582
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.576
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.570
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.551
3cse	N22	Uncharacterized protein	/	0.548
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.547
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.547
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.546
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.546
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.534
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.528
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.527
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.527
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.511
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.507
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.507
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.500
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.500
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.499
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.497
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.495
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.495
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.495
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.494
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.493
3qly	55V	Uncharacterized protein	/	0.493
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.492
4h98	14Q	Uncharacterized protein	/	0.490
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.490
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.489
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.487
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.484
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.484
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.484
3qlx	QLR	Uncharacterized protein	/	0.484
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.484
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.484
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.482
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.481
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.481
3eek	53S	Uncharacterized protein	/	0.481
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.480
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.480
3qlz	QLZ	Uncharacterized protein	/	0.480
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.479
3eem	53V	Uncharacterized protein	/	0.479
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.476
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.474
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.474
3eej	53R	Uncharacterized protein	/	0.472
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.472
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.471
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.469
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.466
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.465
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.465
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.463
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.463
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.461
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.460
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.460
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.460
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.460
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.459
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.457
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.455
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.455
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.455
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.453
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.452
3eel	53T	Uncharacterized protein	/	0.452
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.450
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.450
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.450
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.450
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.448
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.446
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.446
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.445
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.444
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.443
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.442
4jib	1L6	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.442
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.440