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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4jvr1MTE3 ubiquitin-protein ligase Mdm26.3.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4jvr1MTE3 ubiquitin-protein ligase Mdm26.3.21.000
4jwr1MYE3 ubiquitin-protein ligase Mdm26.3.20.532
1rv1IMZE3 ubiquitin-protein ligase Mdm26.3.20.505
4erf0R3E3 ubiquitin-protein ligase Mdm26.3.20.504
4dijBLFE3 ubiquitin-protein ligase Mdm26.3.20.483
1u3dFADCryptochrome-1/0.466
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.446
1u3cFADCryptochrome-1/0.445
4bb3KKAIsopenicillin N synthase1.21.3.10.444
4isk1JYThymidylate synthase/0.444
1owlFADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
3tqhNDPQuinone oxidoreductase/0.440