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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.101.000
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.589
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.571
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.562
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.560
3iczPB6Farnesyl pyrophosphate synthase/0.530
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.515
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.510
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.502
3rywK9HFarnesyl pyrophosphate synthase, putative/0.468
3egt722Farnesyl pyrophosphate synthase/0.460
3tfn2CJDehydrosqualene synthase/0.455
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.443
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440