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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4jrnANPRhoptry kinase family protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4jrnANPRhoptry kinase family protein/1.000
3c4wATPRhodopsin kinase/0.557
3c4zADPRhodopsin kinase/0.536
3qc9ADPRhodopsin kinase/0.510
4ii5ADPCyclin-dependent kinase 22.7.11.220.508
1ir3ANPInsulin receptor2.7.10.10.507
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.506
4eooATPCyclin-dependent kinase 22.7.11.220.505
3t8oATPRhodopsin kinase/0.501
4qmlANPSerine/threonine-protein kinase 242.7.11.10.501
4bbe3O4Tyrosine-protein kinase JAK2/0.498
1jkkANPDeath-associated protein kinase 12.7.11.10.492
4xlvACPInsulin receptor2.7.10.10.492
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.491
4k33ACPFibroblast growth factor receptor 32.7.10.10.491
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.490
4l9i8PRRhodopsin kinase/0.490
3bu5ATPInsulin receptor2.7.10.10.486
4i3zADPCyclin-dependent kinase 22.7.11.220.486
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.483
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.482
1b39ATPCyclin-dependent kinase 22.7.11.220.481
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.480
3c4xATPRhodopsin kinase/0.480
5eg3ACPFibroblast growth factor receptor 2/0.480
1b38ATPCyclin-dependent kinase 22.7.11.220.479
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.479
2w4jADPDeath-associated protein kinase 12.7.11.10.479
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.475
5dnrATPAurora kinase A2.7.11.10.475
2cjmATPCyclin-dependent kinase 22.7.11.220.474
1ig1ANPDeath-associated protein kinase 12.7.11.10.473
1jstATPCyclin-dependent kinase 22.7.11.220.473
4lyn1YGCyclin-dependent kinase 22.7.11.220.473
1qmzATPCyclin-dependent kinase 22.7.11.220.472
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.472
3oriAGSSerine/threonine protein kinase/0.472
4s32ANPMitogen-activated protein kinase 12.7.11.240.472
4h3qANPMitogen-activated protein kinase 12.7.11.240.471
2j0lANPFocal adhesion kinase 12.7.10.20.470
3my5RFZCyclin-dependent kinase 22.7.11.220.470
4s33ANPMitogen-activated protein kinase 12.7.11.240.470
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.470
2etm7PYFocal adhesion kinase 12.7.10.20.469
3ormAGSSerine/threonine protein kinase/0.468
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.468
4ysjADPCalmodulin-like domain protein kinase/0.468
2y9qANPMitogen-activated protein kinase 12.7.11.240.466
4bcmT7ZCyclin-dependent kinase 22.7.11.220.466
3i60E86Mitogen-activated protein kinase 12.7.11.240.465
4n57ADPAPH(2'')-Id/0.464
5e92ANPTGF-beta receptor type-22.7.11.300.464
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.463
3nieANPMitogen-activated protein kinase/0.463
5dosATPAurora kinase A2.7.11.10.463
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.462
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.461
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
3zxtACPDeath-associated protein kinase 12.7.11.10.461
4ic7ANPMitogen-activated protein kinase 72.7.11.240.461
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
1cm8ANPMitogen-activated protein kinase 12/0.459
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.459
4nifANPMitogen-activated protein kinase 12.7.11.240.459
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4xj3GTPCyclic GMP-AMP synthase/0.459
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.458
2acxANPG protein-coupled receptor kinase 62.7.11.160.458
3a7hATPSerine/threonine-protein kinase 242.7.11.10.458
3igoANPCalmodulin-domain protein kinase 1, putative/0.458
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.458
5av2KMPDeath-associated protein kinase 12.7.11.10.458
1oiyN41Cyclin-dependent kinase 22.7.11.220.457
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.457
3nynSGVG protein-coupled receptor kinase 62.7.11.160.456
1gy3ATPCyclin-dependent kinase 22.7.11.220.455
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.455
3lfqA28Cyclin-dependent kinase 22.7.11.220.455
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.455
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.454
2x1nX1NCyclin-dependent kinase 22.7.11.220.454
3c50ADPRhodopsin kinase/0.454
4o1pANPRibonuclease L/0.454
4s34ANPMitogen-activated protein kinase 12.7.11.240.454
5dt3ATPAurora kinase A2.7.11.10.454
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4fv6E57Mitogen-activated protein kinase 12.7.11.240.453
4gt3ATPMitogen-activated protein kinase 12.7.11.240.453
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.453
3bqr4RBDeath-associated protein kinase 3/0.452
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4bbfO19Tyrosine-protein kinase JAK2/0.452
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.451
2a0cCK9Cyclin-dependent kinase 22.7.11.220.451
2btsU32Cyclin-dependent kinase 22.7.11.220.451
3q5iANPProtein kinase, putative/0.451
3r73X87Cyclin-dependent kinase 22.7.11.220.451
5auwQUEDeath-associated protein kinase 12.7.11.10.451
2izrBRKCasein kinase I isoform gamma-32.7.11.10.450
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.450
4deeADPAurora kinase A2.7.11.10.450
3qyw6PBMitogen-activated protein kinase 12.7.11.240.449
3wfjNAD2-dehydropantoate 2-reductase/0.449
4btjATPTau-tubulin kinase 12.7.11.10.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
2cciATPCyclin-dependent kinase 22.7.11.220.448
2ijmATPFocal adhesion kinase 12.7.10.20.448
2j0m4STFocal adhesion kinase 12.7.10.20.448
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.448
3lfsA07Cyclin-dependent kinase 22.7.11.220.448
3orkAGSSerine/threonine protein kinase/0.448
3plsANPMacrophage-stimulating protein receptor2.7.10.10.448
4eomATPCyclin-dependent kinase 22.7.11.220.448
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.447
1tvoFRZMitogen-activated protein kinase 12.7.11.240.447
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
3gu6ADPDeath-associated protein kinase 12.7.11.10.447
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.447
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.447
4riyADPEpidermal growth factor receptor2.7.10.10.447
5cnnANPEpidermal growth factor receptor2.7.10.10.447
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.446
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.446
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.446
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.446
5av3KMPDeath-associated protein kinase 12.7.11.10.446
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.445
3ezrEZRCyclin-dependent kinase 22.7.11.220.445
4bcqTJFCyclin-dependent kinase 22.7.11.220.445
4f9wLM4Mitogen-activated protein kinase 14/0.445
2ji8FYNOxalyl-CoA decarboxylase4.1.1.80.444
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.444
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
4crsAGSSerine/threonine-protein kinase N22.7.11.130.444
4g170VNCasein kinase I isoform gamma-32.7.11.10.444
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.444
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.444
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
5dt4ATPAurora kinase A2.7.11.10.444
2ckeIQUDeath-associated protein kinase 2/0.443
2fvdLIACyclin-dependent kinase 22.7.11.220.443
2vu3LZECyclin-dependent kinase 22.7.11.220.443
3qrtX14Cyclin-dependent kinase 22.7.11.220.443
4cd0AWJALK tyrosine kinase receptor2.7.10.10.443
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.443
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1h1s4SPCyclin-dependent kinase 22.7.11.220.442
1pxpCK8Cyclin-dependent kinase 22.7.11.220.442
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.442
2c5yMTWCyclin-dependent kinase 22.7.11.220.442
2henADPEphrin type-B receptor 22.7.10.10.442
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.442
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.442
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
1hckATPCyclin-dependent kinase 22.7.11.220.441
1ykr628Cyclin-dependent kinase 22.7.11.220.441
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.441
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.441
2wpa889Cyclin-dependent kinase 22.7.11.220.441
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.441
3tnwF18Cyclin-dependent kinase 22.7.11.220.441
4fmqANPMitogen-activated protein kinase 12.7.11.240.441
1csnATPCasein kinase I homolog 12.7.11.10.440
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.440
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.440
4o0wADNAurora kinase A2.7.11.10.440