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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4jbqVX6Aurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4jbqVX6Aurora kinase A2.7.11.11.000
4jbpYPHAurora kinase A2.7.11.10.624
4jboWPHAurora kinase A2.7.11.10.570
4o0uADNAurora kinase A2.7.11.10.567
3k5uPFQAurora kinase A2.7.11.10.563
4aotGW8Serine/threonine-protein kinase 102.7.11.10.553
5l8lADPAurora kinase A2.7.11.10.543
5dnrATPAurora kinase A2.7.11.10.535
3efwAK8Aurora kinase A2.7.11.10.521
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.512
3e5aVX6Aurora kinase A2.7.11.10.510
5dr9SKEAurora kinase A2.7.11.10.510
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.509
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.509
1bygSTUTyrosine-protein kinase CSK/0.508
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.507
2wqeADPAurora kinase A2.7.11.10.506
2vrx447Aurora kinase B-A2.7.11.10.505
2c6eHPMAurora kinase A2.7.11.10.504
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.503
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.503
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.500
3w18N13Aurora kinase A2.7.11.10.495
4c3pACPAurora kinase A2.7.11.10.493
1ol7ADPAurora kinase A2.7.11.10.492
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.492
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.491
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.491
5dosATPAurora kinase A2.7.11.10.489
5drdATPAurora kinase A2.7.11.10.489
4gmy0X5Tyrosine-protein kinase JAK2/0.488
3uo50BXAurora kinase A2.7.11.10.487
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.486
4i22IREEpidermal growth factor receptor2.7.10.10.486
5dn3ATPAurora kinase A2.7.11.10.486
2ijmATPFocal adhesion kinase 12.7.10.20.485
4wsqKSAAP2-associated protein kinase 12.7.11.10.485
2j4z626Aurora kinase A2.7.11.10.484
3l8p0CEAngiopoietin-1 receptor2.7.10.10.484
4o0wADNAurora kinase A2.7.11.10.484
2dwbANPAurora kinase A2.7.11.10.483
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.483
2excJNKMitogen-activated protein kinase 102.7.11.240.482
1pmn984Mitogen-activated protein kinase 102.7.11.240.480
5dt3ATPAurora kinase A2.7.11.10.480
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.479
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.479
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.479
2np8CC3Aurora kinase A2.7.11.10.478
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.478
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.478
4hvi19STyrosine-protein kinase JAK32.7.10.20.478
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.477
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.477
3ttjJBIMitogen-activated protein kinase 102.7.11.240.477
5dr6SKEAurora kinase A2.7.11.10.475
3ztxZTXAurora kinase B-A2.7.11.10.474
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.474
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.474
3a62STURibosomal protein S6 kinase beta-12.7.11.10.473
3ggfGVDSerine/threonine-protein kinase 26/0.473
1ol5ADPAurora kinase A2.7.11.10.472
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.472
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.471
4b0gVEKAurora kinase A2.7.11.10.471
4c4g7RODual specificity protein kinase TTK2.7.12.10.471
4c58824Cyclin-G-associated kinase2.7.11.10.471
4deaNHIAurora kinase A2.7.11.10.470
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.469
2j0lANPFocal adhesion kinase 12.7.10.20.469
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.469
3bfb9ODPheromone-binding protein ASP1/0.469
4c4h7RODual specificity protein kinase TTK2.7.12.10.469
4id71G0Activated CDC42 kinase 1/0.469
2qo9ANPEphrin type-A receptor 32.7.10.10.468
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.468
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.468
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
1yb5NAPQuinone oxidoreductase1.6.5.50.467
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.467
5dt0SKEAurora kinase A2.7.11.10.467
5dt4ATPAurora kinase A2.7.11.10.467
2hog710Serine/threonine-protein kinase Chk12.7.11.10.466
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.465
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.465
3w16P9JAurora kinase A2.7.11.10.465
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.465
4utdACPAurora kinase A2.7.11.10.465
2x6dX6DAurora kinase A2.7.11.10.464
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.464
3gyiFADCholesterol oxidase1.1.3.60.464
1cc2FADCholesterol oxidase1.1.3.60.463
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3r9hZ67Cyclin-dependent kinase 22.7.11.220.463
4jia1K3Tyrosine-protein kinase JAK2/0.463
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
5dr2ATPAurora kinase A2.7.11.10.463
2w1fL0FAurora kinase A2.7.11.10.462
2xneASHAurora kinase A2.7.11.10.462
2xrwANPMitogen-activated protein kinase 82.7.11.240.462
4fob0USALK tyrosine kinase receptor2.7.10.10.462
4nka2K7Fibroblast growth factor receptor 1/0.462
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.461
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.461
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.461
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.461
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.461
2q61SF1Peroxisome proliferator-activated receptor gamma/0.460
2x9fX9FEphrin type-B receptor 42.7.10.10.460
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.460
3slkNDPPolyketide synthase extender module 2/0.460
3ttiKBIMitogen-activated protein kinase 102.7.11.240.460
1n4uFAECholesterol oxidase1.1.3.60.459
1ot7CHCBile acid receptor/0.459
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.459
4bbe3O4Tyrosine-protein kinase JAK2/0.459
4c4f7CEDual specificity protein kinase TTK2.7.12.10.459
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.458
2aazCB3Thymidylate synthase2.1.1.450.458
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.458
3t8oATPRhodopsin kinase/0.458
3w2sW2REpidermal growth factor receptor2.7.10.10.458
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.458
5dpvSKEAurora kinase A2.7.11.10.458
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.457
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.457
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.457
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.456
3bu5ATPInsulin receptor2.7.10.10.456
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.456
4c4iX20Dual specificity protein kinase TTK2.7.12.10.456
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.456
4qi4FADCellobiose dehydrogenase/0.456
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
3c4xATPRhodopsin kinase/0.455
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
4jajXU1Aurora kinase A2.7.11.10.455
1k6cMK1Gag-Pol polyprotein3.4.23.160.454
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.454
2bmcMPYAurora kinase A2.7.11.10.454
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.454
2qo7ANPEphrin type-A receptor 32.7.10.10.454
3oriAGSSerine/threonine protein kinase/0.454
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.454
4g7gVFVLanosterol 14-alpha-demethylase/0.454
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.454
5awmANPStress-activated protein kinase JNK2.7.11.240.454
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.453
2etm7PYFocal adhesion kinase 12.7.10.20.453
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.453
3hx4ANPCalmodulin-domain protein kinase 1/0.453
3oom507Activin receptor type-12.7.11.300.453
4anqVGHALK tyrosine kinase receptor2.7.10.10.453
4qi7FADCellobiose dehydrogenase/0.453
4rekFADCholesterol oxidase1.1.3.60.453
1b8sFADCholesterol oxidase1.1.3.60.452
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.452
1osvCHCBile acid receptor/0.452
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.452
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
2xvdAS6Ephrin type-B receptor 42.7.10.10.452
3mtfA3FActivin receptor type-12.7.11.300.452
4b7xNAPProbable oxidoreductase/0.452
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.452
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.452
2j0m4STFocal adhesion kinase 12.7.10.20.451
2p33J07Mitogen-activated protein kinase 102.7.11.240.451
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.451
3vquO22Dual specificity protein kinase TTK2.7.12.10.451
4c3rACPAurora kinase A2.7.11.10.451
4fv7E94Mitogen-activated protein kinase 12.7.11.240.451
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.451
1drbMTXDihydrofolate reductase1.5.1.30.450
2o2u738Mitogen-activated protein kinase 102.7.11.240.450
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.450
3c4zADPRhodopsin kinase/0.450
4aqc88ATyrosine-protein kinase JAK2/0.450
4bgg844Activin receptor type-12.7.11.300.450
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.450
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2bfyH1NAurora kinase B-A2.7.11.10.449
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.449
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.449
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.449
2om9AJAPeroxisome proliferator-activated receptor gamma/0.449
2q5g1FAPeroxisome proliferator-activated receptor delta/0.449
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.449
4qecNAPElxO/0.449
4qmlANPSerine/threonine-protein kinase 242.7.11.10.449
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1ha3MAUElongation factor Tu-A/0.448
1ie8KH1Vitamin D3 receptor/0.448
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.448
2o0uC0MMitogen-activated protein kinase 102.7.11.240.448
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.448
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.448
3t14FADSulfide-quinone reductase/0.448
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.448
3ziaATPATP synthase subunit alpha, mitochondrial/0.448
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.448
5ap57RODual specificity protein kinase TTK2.7.12.10.448
1a72PADAlcohol dehydrogenase E chain1.1.1.10.447
1ol6ATPAurora kinase A2.7.11.10.447
3bfa9ODOdorant binding protein ASP1/0.447
3l0lHC3Nuclear receptor ROR-gamma/0.447
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.447
3t2zFADSulfide-quinone reductase/0.447
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4deeADPAurora kinase A2.7.11.10.447
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.447
4fuxE75Mitogen-activated protein kinase 12.7.11.240.447
4q71FADBifunctional protein PutA/0.447
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.446
1qbu846Gag-Pol polyprotein3.4.23.160.446
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.446
3h1vTK1Glucokinase2.7.1.20.446
3mdvCL6Cholesterol 24-hydroxylase/0.446
3r9dX6BCyclin-dependent kinase 22.7.11.220.446
4c62XWWTyrosine-protein kinase JAK2/0.446
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.446
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.445
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.445
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.445
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.445
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4f07FADStyrene monooxygenase component 2/0.445
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.445
4nb6444Nuclear receptor ROR-gamma/0.445
4qi5FADCellobiose dehydrogenase/0.445
1e3eNAIAlcohol dehydrogenase 41.1.1.10.444
2gtk208Peroxisome proliferator-activated receptor gamma/0.444
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.444
3h86AP5Adenylate kinase/0.444
3p3e3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.444
3tqhNDPQuinone oxidoreductase/0.444
3uzp0CKCasein kinase I isoform delta2.7.11.10.444
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.444
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.444
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.444
4xxgFADCholesterol oxidase1.1.3.60.444
1eh4IC1Casein kinase I homolog 12.7.11.10.443
1mq4ADPAurora kinase A2.7.11.10.443
1zeoC01Peroxisome proliferator-activated receptor gamma/0.443
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.443
2q5p241Peroxisome proliferator-activated receptor gamma/0.443
3cgfJNFMitogen-activated protein kinase 102.7.11.240.443
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.443
3zep1NXTyrosine-protein kinase JAK32.7.10.20.443
4c57FEFCyclin-G-associated kinase2.7.11.10.443
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.443
4wboANWRhodopsin kinase/0.443
4xumIMNPeroxisome proliferator-activated receptor gamma/0.443
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.443
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.442
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.442
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2qoqANPEphrin type-A receptor 32.7.10.10.442
2xp2VGHALK tyrosine kinase receptor2.7.10.10.442
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.442
3d7tSTUTyrosine-protein kinase CSK/0.442
3jynNDPQuinone oxidoreductase/0.442
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.442
4lrjANPUncharacterized protein/0.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
4yryFADGlutamate synthase, beta subunit/0.442
1kkq471Peroxisome proliferator-activated receptor alpha/0.441
2c3qGTXGlutathione S-transferase theta-12.5.1.180.441
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.441
2ft9CHDFatty acid-binding protein 2, liver/0.441
2q9fC3SCholesterol 24-hydroxylase/0.441
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.441
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.441
3vs1VSATyrosine-protein kinase HCK2.7.10.20.441
4hge15VTyrosine-protein kinase JAK2/0.441
4n6bCOAUncharacterized protein/0.441
5aacVGHALK tyrosine kinase receptor2.7.10.10.441
1dawANPCasein kinase II subunit alpha2.7.11.10.440
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.440
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.440
1zhwHC2Oxysterol-binding protein homolog 4/0.440
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.440
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3qc9ADPRhodopsin kinase/0.440
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.440
4aguD15Cyclin-dependent kinase-like 1/0.440
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.440
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.440
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.440
4g3jVNTLanosterol 14-alpha-demethylase/0.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.440
4u2sFDACholesterol oxidase1.1.3.60.440
4zohFADPutative oxidoreductase FAD-binding subunit/0.440
5cshATPCasein kinase II subunit alpha2.7.11.10.440