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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4jboWPHAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4jboWPHAurora kinase A2.7.11.11.000
4jbpYPHAurora kinase A2.7.11.10.656
5dosATPAurora kinase A2.7.11.10.538
5dnrATPAurora kinase A2.7.11.10.515
4c3pACPAurora kinase A2.7.11.10.513
4deeADPAurora kinase A2.7.11.10.513
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.509
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.509
4o0uADNAurora kinase A2.7.11.10.507
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.506
5drdATPAurora kinase A2.7.11.10.498
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.497
3efwAK8Aurora kinase A2.7.11.10.495
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.488
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.488
4jbqVX6Aurora kinase A2.7.11.10.484
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.481
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.481
2c6eHPMAurora kinase A2.7.11.10.477
3k5uPFQAurora kinase A2.7.11.10.477
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.475
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.474
5l8lADPAurora kinase A2.7.11.10.473
3c4xATPRhodopsin kinase/0.471
4aotGW8Serine/threonine-protein kinase 102.7.11.10.468
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.468
3w18N13Aurora kinase A2.7.11.10.465
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.463
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.463
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.463
4qnyANPMitogen activated protein kinase, putative/0.461
2wqeADPAurora kinase A2.7.11.10.457
3bu5ATPInsulin receptor2.7.10.10.453
2j0lANPFocal adhesion kinase 12.7.10.20.452
2vrx447Aurora kinase B-A2.7.11.10.452
2w4jADPDeath-associated protein kinase 12.7.11.10.452
2yaaATPDeath-associated protein kinase 2/0.449
3lltANPProtein serine/threonine kinase-1/0.448
3gu7ADPDeath-associated protein kinase 12.7.11.10.447
4ysjADPCalmodulin-like domain protein kinase/0.446
1ig1ANPDeath-associated protein kinase 12.7.11.10.445
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.445
2ijmATPFocal adhesion kinase 12.7.10.20.442
1jklANPDeath-associated protein kinase 12.7.11.10.441
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.440