sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.672 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.652 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.639 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.626 | |
| 3qly | 55V | Uncharacterized protein | / | 0.613 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.602 | |
| 3eek | 53S | Uncharacterized protein | / | 0.601 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.595 | |
| 3cse | N22 | Uncharacterized protein | / | 0.592 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.583 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.581 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.578 | |
| 3eej | 53R | Uncharacterized protein | / | 0.573 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.573 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.569 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3eel | 53T | Uncharacterized protein | / | 0.562 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.560 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.558 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.558 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.555 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.551 | |
| 3eem | 53V | Uncharacterized protein | / | 0.551 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.548 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.547 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.547 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.546 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.543 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.543 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.542 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.540 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.534 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.526 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.512 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.511 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.510 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.504 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.503 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.502 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.501 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.499 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.498 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.496 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.494 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.494 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.493 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.490 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.490 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.490 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.489 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.487 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.485 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.483 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.483 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.482 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.482 | |
| 1yin | CM3 | Estrogen receptor | / | 0.481 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.481 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.481 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.481 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.481 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.479 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.478 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.477 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.475 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.475 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.475 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.473 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.473 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.472 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.471 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.471 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.470 | |
| 2p15 | EZT | Estrogen receptor | / | 0.470 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.470 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.470 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.470 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.470 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.469 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.468 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.467 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.467 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.466 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.465 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.465 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.465 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.465 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.465 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.464 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.464 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.464 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.464 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.464 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.464 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.464 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.464 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.464 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.464 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1e7a | PFL | Serum albumin | / | 0.463 | |
| 1nq1 | 4HY | Thyroid hormone receptor beta | / | 0.463 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.463 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 4in4 | 4ID | Kelch-like ECH-associated protein 1 | / | 0.463 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.462 | |
| 2fai | 459 | Estrogen receptor | / | 0.462 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.462 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.462 | |
| 3r7c | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.462 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.462 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.462 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.462 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.461 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.461 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.461 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.461 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.461 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.461 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.461 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.461 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.461 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.460 | |
| 2b1z | 17M | Estrogen receptor | / | 0.460 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.460 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.460 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.460 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.460 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.459 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.458 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.458 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.458 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.458 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.458 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.458 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.457 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.457 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.456 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.456 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.456 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.456 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.456 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.456 | |
| 4pxm | EST | Estrogen receptor | / | 0.456 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.456 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.455 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.455 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.455 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2q6s | PLB | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.455 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.455 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.455 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.455 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.455 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.455 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.454 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.454 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.454 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.454 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.454 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.454 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.454 | |
| 3v49 | PK0 | Androgen receptor | / | 0.454 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.454 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.454 | |
| 4b1f | KRH | Glutamate racemase | / | 0.454 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.454 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.454 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.453 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.453 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.453 | |
| 4egn | TWO | Cytochrome P450 | / | 0.453 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.453 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.453 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.453 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.453 | |
| 1fml | RTL | Retinol dehydratase | / | 0.452 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.452 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1ppj | SMA | Cytochrome b | / | 0.452 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.452 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.452 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.452 | |
| 2pan | TDP | Glyoxylate carboligase | 4.1.1.47 | 0.452 | |
| 2pnu | ENM | Androgen receptor | / | 0.452 | |
| 2w03 | ADN | AcsD | / | 0.452 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.452 | |
| 2ync | YNC | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.452 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.452 | |
| 3lu8 | IQX | Serum albumin | / | 0.452 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.452 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.451 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.451 | |
| 1owo | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.451 | |
| 1pp9 | SMA | Cytochrome b | / | 0.451 | |
| 1qxo | FMN | Chorismate synthase | / | 0.451 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.451 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.451 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.451 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.451 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.451 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3dtc | VIN | Mitogen-activated protein kinase kinase kinase 9 | 2.7.11.25 | 0.451 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3k2h | LYA | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.451 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.451 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.451 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.450 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.450 | |
| 2wsa | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.450 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3m31 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.450 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.450 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.450 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.450 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.449 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.449 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.449 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.449 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 2w4i | VGA | Glutamate racemase | / | 0.449 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.449 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 4cgp | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.449 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.449 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.449 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.448 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.448 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.448 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.448 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.448 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.448 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.448 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.448 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.448 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.448 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.448 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.448 | |
| 1hk2 | T44 | Serum albumin | / | 0.447 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1sj0 | E4D | Estrogen receptor | / | 0.447 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.447 | |
| 1x7e | 244 | Estrogen receptor | / | 0.447 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.447 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.447 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.447 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.447 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.447 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 4a28 | ADP | Kinesin-like protein KIF11 | / | 0.447 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.447 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.447 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.447 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1ckp | PVB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.446 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2j0d | ERY | Cytochrome P450 3A4 | / | 0.446 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.446 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.446 | |
| 5a27 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.446 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.445 | |
| 1eio | GCH | Gastrotropin | / | 0.445 | |
| 1ezv | SMA | Cytochrome b | / | 0.445 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.445 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.445 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.445 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.445 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.445 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3b9l | AZZ | Serum albumin | / | 0.445 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.445 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.445 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 4udc | DEX | Glucocorticoid receptor | / | 0.445 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.445 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.445 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.444 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.444 | |
| 2d09 | FLV | Biflaviolin synthase CYP158A2 | / | 0.444 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.444 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.444 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.444 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.444 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3vbq | 0F5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.444 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 5bn3 | ADP | V-type ATP synthase alpha chain | / | 0.444 | |
| 5bn3 | ADP | NEQ263 | / | 0.444 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.443 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.443 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.443 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.443 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.443 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.443 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3iod | A6D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.443 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.443 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4oth | DRN | Serine/threonine-protein kinase N1 | / | 0.443 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.443 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.442 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.442 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.442 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.442 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.442 | |
| 2x7f | 824 | TRAF2 and NCK-interacting protein kinase | 2.7.11.1 | 0.442 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.442 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 4ach | KDI | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.442 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.442 | |
| 4l8u | 9AZ | Serum albumin | / | 0.442 | |
| 4oae | CLM | Uncharacterized protein | / | 0.442 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.442 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 1gsf | EAA | Glutathione S-transferase A1 | 2.5.1.18 | 0.441 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.441 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2jfz | 003 | Glutamate racemase | / | 0.441 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.441 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.441 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.441 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.441 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.441 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4a51 | DQ8 | Kinesin-like protein KIF11 | / | 0.441 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4c68 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.441 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1err | RAL | Estrogen receptor | / | 0.440 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.440 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.440 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.440 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.440 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.440 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.440 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4b12 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4bqu | CLR | Japanin | / | 0.440 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |