scPDB - Distribution of Binding site Similarity values of 4ixe entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4ixe	IXE	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	1.000
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.636
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.608
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.597
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.580
3qlz	QLZ	Uncharacterized protein	/	0.579
3cse	N22	Uncharacterized protein	/	0.575
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.570
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.562
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.561
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.558
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.557
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.557
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.556
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.553
3qly	55V	Uncharacterized protein	/	0.550
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.545
3qlx	QLR	Uncharacterized protein	/	0.545
3eem	53V	Uncharacterized protein	/	0.543
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.542
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.539
3eek	53S	Uncharacterized protein	/	0.534
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.533
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.532
3eel	53T	Uncharacterized protein	/	0.531
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.527
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.524
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.523
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.523
4h98	14Q	Uncharacterized protein	/	0.519
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.517
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.517
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.516
2w3v	TOP	Dihydrofolate reductase	/	0.515
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.515
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.514
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.512
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.512
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.509
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.508
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.508
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.505
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.505
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.504
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.503
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.503
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.500
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.500
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.499
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.494
2zza	FOL	Dihydrofolate reductase	/	0.492
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.491
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.490
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.489
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.489
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.489
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.487
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.486
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.485
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.484
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.483
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.482
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.481
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.481
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.480
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.480
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.480
3eej	53R	Uncharacterized protein	/	0.480
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.477
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.476
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.476
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.476
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.476
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.475
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.473
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.472
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.472
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
3sa1	6DR	Dihydrofolate reductase	/	0.470
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.469
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.468
4p66	MTX	Dihydrofolate reductase	/	0.468
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.467
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.466
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.465
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.465
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.465
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.464
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.463
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.463
3ia4	MTX	Dihydrofolate reductase	/	0.463
1m79	MQ1	Dihydrofolate reductase	1.5.1.3	0.462
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.461
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.461
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.461
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.460
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.460
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.458
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.456
3tqb	FOL	Dihydrofolate reductase	/	0.456
3jwc	EKB	Dihydrofolate reductase	/	0.455
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.454
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.452
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.450
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.449
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.449
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.448
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.448
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.447
3jwm	5WB	Dihydrofolate reductase	/	0.447
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.447
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.447
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.446
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.446
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.444
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.443
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.442
3sa2	7DR	Dihydrofolate reductase	/	0.442
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.441
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.440
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.440