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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4iv6FDAIsovaleryl-CoA dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4iv6FDAIsovaleryl-CoA dehydrogenase/1.000
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.529
3owaFADAcyl-CoA dehydrogenase/0.526
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.522
3p4tFAOPutative acyl-CoA dehydrogenase/0.519
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.518
5af7FADAcyl-CoA dehydrogenase/0.512
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.510
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.509
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.505
2z1qFADAcyl-CoA dehydrogenase/0.501
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.491
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.491
3r7kFDAProbable acyl CoA dehydrogenase/0.490
2ebaFADPutative glutaryl-CoA dehydrogenase/0.486
4x28FDAAcyl-CoA dehydrogenase FadE26/0.484
4x28FDAAcyl-CoA dehydrogenase FadE27/0.484
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.480
4irnFADAnaB/0.472
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.470
5jscFADPutative acyl-CoA dehydrogenase/0.469
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.463