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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.11.000
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.533
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.528
4j7uNAPSepiapterin reductase1.1.1.1530.519
4hwkNAPSepiapterin reductase1.1.1.1530.513
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.509
2dteNAIGlucose 1-dehydrogenase related protein/0.509
1snyNAPLD36273p/0.503
4j7xNAPSepiapterin reductase1.1.1.1530.500
1pr9NAPL-xylulose reductase1.1.1.100.499
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.495
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.495
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.495
1ipeNDPTropinone reductase 21.1.1.2360.493
1oaaNAPSepiapterin reductase1.1.1.1530.493
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.492
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.490
1wntNAPL-xylulose reductase1.1.1.100.488
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.486
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.483
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.483
5idwNAPShort-chain dehydrogenase/reductase SDR/0.483
4gh5NADShort-chain dehydrogenase/reductase SDR/0.482
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.480
3d3wNAPL-xylulose reductase1.1.1.100.479
3sjuNDPKeto reductase/0.478
2yy7NADL-threonine dehydrogenase/0.474
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.473
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.473
3s55NADPutative short-chain dehydrogenase/reductase/0.469
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.467
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.467
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.466
4qecNAPElxO/0.466
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.465
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.463
3wdsNADNADH-dependent quinuclidinone reductase/0.463
4yaiNAIC alpha-dehydrogenase/0.463
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.463
1w4zNAPPutative ketoacyl reductase1.3.10.461
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.461
3uceNDPDehydrogenase/0.459
4dc1NDPPutative ketoacyl reductase1.3.10.459
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.458
2wdzNADGalactitol dehydrogenase/0.458
3vdqNAD3-hydroxybutyrate dehydrogenase/0.458
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3gy0NAPNAD(P)-dependent oxidoreductase/0.457
4b8wNAPGDP-L-fucose synthase1.1.1.2710.457
5jlaNADPutative short-chain dehydrogenase/reductase/0.457
1rkxNADCDP-D-glucose-4,6-dehydratase/0.456
3toxNAPPutative oxidoreductase/0.455
4b8zNAPGDP-L-fucose synthase1.1.1.2710.455
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.455
1n5dNDPCarbonyl reductase [NADPH] 1/0.453
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.453
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.453
5lc1NADL-threonine 3-dehydrogenase/0.453
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.452
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.451
2wsbNADGalactitol dehydrogenase/0.450
5jydNADShort chain dehydrogenase/0.450
1ae1NAPTropinone reductase 1/0.449
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.449
3w8eNAD3-hydroxybutyrate dehydrogenase/0.449
4yagNAIC alpha-dehydrogenase/0.449
1xg5NAPDehydrogenase/reductase SDR family member 11/0.448
3p19NDPPutative blue fluorescent protein/0.448
4bmvNAPShort-chain dehydrogenase/0.448
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
3ak4NADNADH-dependent quinuclidinone reductase/0.447
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
3w8dNAD3-hydroxybutyrate dehydrogenase/0.444
2yutNAPPutative short-chain oxidoreductase/0.443
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1xkqNDPUncharacterized protein/0.442
1g6kNADGlucose 1-dehydrogenase1.1.1.470.441
1rwbNADGlucose 1-dehydrogenase1.1.1.470.441
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2jahNDPClavaldehyde dehydrogenase/0.440
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.440