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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4irrUMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4irrUMPThymidylate synthase/1.000
3qj7UMPThymidylate synthase ThyA/0.632
5by6UMPThymidylate synthase/0.626
4eb4UMPThymidylate synthase2.1.1.450.587
4h0uUMPThymidylate synthase/0.582
4psgNOHThymidylate synthase/0.572
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.567
1bidUMPThymidylate synthase/0.564
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.564
4e5oUMPThymidylate synthase2.1.1.450.561
1ci7UMPThymidylate synthase2.1.1.450.559
4xsdUMPThymidylate synthase2.1.1.450.558
4dq1UMPThymidylate synthase/0.536
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.534
1bduDURThymidylate synthase/0.530
4einNOHThymidylate synthase2.1.1.450.530
1aobDDUThymidylate synthase/0.526
1njbUMPThymidylate synthase/0.517
1jmgUMPThymidylate synthase/0.515
4iqqUMPThymidylate synthase/0.513
2vetUMPThymidylate synthase/0.512
2g8aUMPThymidylate synthase/0.511
4iskUMPThymidylate synthase/0.511
3bgxTMPThymidylate synthase/0.507
4foxUMPThymidylate synthase ThyA/0.501
1njeDCMThymidylate synthase/0.499
2g86UMPThymidylate synthase/0.493
2tdmUMPThymidylate synthase/0.492
1tsvUMPThymidylate synthase/0.491
3hb8UMPThymidylate synthase2.1.1.450.488
1njaDCMThymidylate synthase/0.487
1vzbUMPThymidylate synthase/0.483
1tsxUMPThymidylate synthase/0.481
1dduDDUThymidylate synthase/0.479
1tduDURThymidylate synthase/0.478
2g89UMPThymidylate synthase/0.478
2g8dUMPThymidylate synthase/0.478
2tsrUMPThymidylate synthase2.1.1.450.478
1njdUMPThymidylate synthase/0.476
1jmfUMPThymidylate synthase/0.475
1b5dDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.472
1bpjUMPThymidylate synthase/0.468
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.466
1jmiUMPThymidylate synthase/0.464
1f28UMPThymidylate synthase2.1.1.450.463
1njcDCMThymidylate synthase/0.463
1jmhUMPThymidylate synthase/0.460
1vzaUMPThymidylate synthase/0.455
3bhlTHGThymidylate synthase/0.453
4fogC2FThymidylate synthase ThyA/0.452
1tsyUMPThymidylate synthase/0.451
2ftoTMPThymidylate synthase/0.451
3bgxMEFThymidylate synthase/0.449
1tysTMPThymidylate synthase/0.447
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
4ihl1F514-3-3 protein zeta/delta/0.443
4lrrCF9Thymidylate synthase/0.442
1lcbTMPThymidylate synthase/0.441
4q71FADBifunctional protein PutA/0.441