sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4imf | SI3 | N-acetylneuraminate lyase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4imf | SI3 | N-acetylneuraminate lyase | / | 1.000 | |
| 4img | NGF | N-acetylneuraminate lyase | / | 0.571 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.489 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.486 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.459 | |
| 3ebf | 332 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.458 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1zzu | DP1 | Nitric oxide synthase, brain | 1.14.13.39 | 0.457 | |
| 1zzr | DP9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.456 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.455 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.454 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.452 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.450 | |
| 2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.448 | |
| 3pi0 | F91 | Endothiapepsin | 3.4.23.22 | 0.448 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.447 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.442 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.440 |