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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ih8B43Calmodulin-domain protein kinase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ih8B43Calmodulin-domain protein kinase 1/1.000
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.582
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.545
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.522
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.521
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.491
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.488
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.485
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.478
3w33W19Epidermal growth factor receptor2.7.10.10.477
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.475
4yuqKS1Calmodulin-like domain protein kinase/0.471
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.468
3p4tFAOPutative acyl-CoA dehydrogenase/0.467
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.465
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.463
3w2cN15Aurora kinase A2.7.11.10.463
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.461
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.460
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.459
4nk92K5Fibroblast growth factor receptor 1/0.459
1jklANPDeath-associated protein kinase 12.7.11.10.458
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
4lopSB4Mitogen-activated protein kinase 14/0.455
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.454
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3abaFLICytochrome P450/0.453
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.453
3w18N13Aurora kinase A2.7.11.10.452
3zk5Z18Cytochrome P450 monooxygenase PikC/0.452
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.450
3hllI45Mitogen-activated protein kinase 14/0.450
4aacAAVMitogen-activated protein kinase 14/0.450
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.450
4kaoKAOFocal adhesion kinase 12.7.10.20.450
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.448
3owaFADAcyl-CoA dehydrogenase/0.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
4i22IREEpidermal growth factor receptor2.7.10.10.445
1jkx138Phosphoribosylglycinamide formyltransferase/0.444
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.444
1g35AHFGag-Pol polyprotein3.4.23.160.443
3gubGUBDeath-associated protein kinase 12.7.11.10.442
3vryB43Tyrosine-protein kinase HCK2.7.10.20.442
4hjoAQ4Epidermal growth factor receptor2.7.10.10.442
1ig1ANPDeath-associated protein kinase 12.7.11.10.441
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.440
3oc4FADOxidoreductase, pyridine nucleotide-disulfide family/0.440
4irnFADAnaB/0.440
4o2z046Mitogen-activated protein kinase/0.440